{"id":"ai-700","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Chest discomfort"}]},"_chembl":{"chemblId":"CHEMBL5919825","moleculeType":null,"molecularWeight":"689.19"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"AI-700 consists of lipid-encapsulated microbubbles that reflect ultrasound waves, improving visualization of vascular flow and tissue perfusion during diagnostic ultrasound imaging. The microbubbles are engineered to remain stable in circulation and provide enhanced contrast for extended imaging windows, enabling better detection and characterization of lesions and perfusion abnormalities.","oneSentence":"AI-700 is an ultrasound contrast agent designed to enhance imaging of blood perfusion and tissue characterization.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:42:28.529Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contrast-enhanced ultrasound imaging for tissue perfusion assessment"},{"name":"Cardiac imaging and left ventricular opacification"}]},"trialDetails":[{"nctId":"NCT04821284","phase":"PHASE1, PHASE2","title":"Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Flemming Forsberg","startDate":"2021-12-06","conditions":"Locally Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8","enrollment":120},{"nctId":"NCT07145801","phase":"PHASE2","title":"Y-90 Treatment Response Using Transarterial Radioembolization","status":"RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2025-09-11","conditions":"HCC, Hepatocellular Carcinoma, Liver Cancer","enrollment":30},{"nctId":"NCT05105087","phase":"EARLY_PHASE1","title":"Gynecological Sentinel Lymph Nodes CEUS","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2022-04-28","conditions":"Cervical Carcinoma, Malignant Female Reproductive System Neoplasm, Vaginal Carcinoma","enrollment":9},{"nctId":"NCT03578224","phase":"EARLY_PHASE1","title":"Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University","startDate":"2018-09-06","conditions":"Esophagus","enrollment":35},{"nctId":"NCT04720456","phase":"PHASE2","title":"SHAPE of Portal Hypertension in Children","status":"RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2021-11-03","conditions":"Hypertension, Portal","enrollment":120},{"nctId":"NCT02733029","phase":"PHASE2","title":"Contrast Enhanced Ultrasonography to Detect Human Renal Transplant Rejection","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2018-05-30","conditions":"Renal Transplant Rejection","enrollment":8},{"nctId":"NCT02652923","phase":"PHASE1, PHASE2","title":"Contrast Ultrasound Detection of Sentinel Lymph Nodes","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University","startDate":"2016-01-01","conditions":"Breast Cancer","enrollment":98},{"nctId":"NCT05068076","phase":"NA","title":"Role of Perfluorobutane in Lesion Detection, Targeting and Response Assessment for Ablation of HCC","status":"COMPLETED","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2021-10-01","conditions":"Hepatocellular Carcinoma, Microwave Ablation","enrollment":21},{"nctId":"NCT04847726","phase":"NA","title":"Contrast-enhanced Ultrasound With Perfluorobutane and Sulfur Hexafluoride for Hepatocellular Carcinoma","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2020-06-09","conditions":"Hepatocellular Carcinoma","enrollment":110},{"nctId":"NCT04961775","phase":"","title":"A Prospective Multi-center Study on Using Sonazoid Diagnose Early Stage Endometrial Cancer","status":"UNKNOWN","sponsor":"Chinese PLA General Hospital","startDate":"2020-10-01","conditions":"Endometrial Carcinoma Stage I","enrollment":277},{"nctId":"NCT04494022","phase":"NA","title":"Role of CEUS as a Secondary Diagnostic Modality","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2020-06-08","conditions":"Hepatocellular Carcinoma","enrollment":120},{"nctId":"NCT02737865","phase":"NA","title":"Superb Microvascular Imaging in Focal Nodular Hyperplasia","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2016-05","conditions":"Focal Nodular Hyperplasia","enrollment":62},{"nctId":"NCT04006275","phase":"PHASE3","title":"Comparing SonoVue With Sonazoid Using CEUS-LIRADS in HCC","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2019-06-30","conditions":"Hepatocellular Carcinoma, Cirrhosis","enrollment":100},{"nctId":"NCT02188901","phase":"NA","title":"Contrast (Sonazoid)-Enhanced US as a Screening Tool for Hepatocellular Carcinoma in Cirrhosis: An Exploratory Cross-sectional Study","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2014-10-15","conditions":"Hepatocellular Carcinoma (HCC)","enrollment":523},{"nctId":"NCT03340870","phase":"PHASE1","title":"A Study to Evaluate Pharmacokinetics of Sonazoid™ Following Intravenous Bolus Injection in Healthy Volunteers","status":"COMPLETED","sponsor":"GE Healthcare","startDate":"2014-10-20","conditions":"Healthy","enrollment":16},{"nctId":"NCT00669851","phase":"PHASE3","title":"Acquiring Consensus for Contrast Echocardiography System Settings - ACCESS Study","status":"COMPLETED","sponsor":"Acusphere","startDate":"2006-11","conditions":"Coronary Artery Disease","enrollment":39},{"nctId":"NCT00670332","phase":"","title":"Prognostic Assessment of Contrast Echocardiography (PACE Study)","status":"TERMINATED","sponsor":"Acusphere","startDate":"2007-07","conditions":"Coronary Artery Disease","enrollment":773},{"nctId":"NCT00156780","phase":"PHASE1","title":"Phase 1 Safety and Pharmacokinetic Study of AI-700 in Patients With Diminished DLCO and COPD and/or CHF","status":"COMPLETED","sponsor":"Acusphere","startDate":"2004-08","conditions":"Congestive Heart Failure, Chronic Obstructive Pulmonary Disease","enrollment":""},{"nctId":"NCT00156793","phase":"PHASE3","title":"Phase 3 Imaging and Safety Study of AI-700 in Patients With Suspected Coronary Artery Disease Undergoing SPECT Imaging","status":"COMPLETED","sponsor":"Acusphere","startDate":"2003-12","conditions":"Coronary Artery Disease","enrollment":400},{"nctId":"NCT00156845","phase":"PHASE3","title":"Phase 3 Safety and Imaging Study of AI-700 in Patients With Suspected Coronary Artery Disease Undergoing Coronary Angiography","status":"COMPLETED","sponsor":"Acusphere","startDate":"2003-12","conditions":"Coronary Artery Disease","enrollment":450}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"AI-700","genericName":"AI-700","companyName":"Acusphere","companyId":"acusphere","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AI-700 is being studied in clinical trials for various conditions, including Hepatocellular Carcinoma, Coronary Artery Disease, Endometrial Carcinoma Stage I, Hepatocellular Carcinoma (HCC), and Congestive Heart Failure. The exact mechanism of AI-700 is not specified in the provided facts, but it is being tested alongside other interventions such as contrast enhanced ultrasound and Perflubutane Microspheres for Injection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}