{"id":"ahes-15-minutes","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The exact mechanism is not publicly detailed, but given the 15-minute application window and the Netherlands Institute for Pigment Disorders' focus, it likely works through stimulation of melanocyte activity or application of pigment-enhancing compounds to affected skin areas. The rapid timeframe suggests a topical cosmetic or therapeutic approach rather than systemic intervention.","oneSentence":"AHES 15 minutes is a topical treatment designed to rapidly improve skin pigmentation disorders through accelerated melanin production or transfer.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:26:12.954Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pigmentation disorders (vitiligo, hypopigmentation, or related conditions)"}]},"trialDetails":[{"nctId":"NCT02548533","phase":"PHASE4","title":"Fractional Laser Assisted Topical Anesthesia","status":"TERMINATED","sponsor":"Netherlands Institute for Pigment Disorders","startDate":"2015-06","conditions":"Cicatrix","enrollment":3},{"nctId":"NCT03279757","phase":"PHASE4","title":"Fractional Laser Assisted Delivery of Anesthetics IIIb","status":"COMPLETED","sponsor":"Netherlands Institute for Pigment Disorders","startDate":"2016-10-01","conditions":"Local Anesthesia of the Skin","enrollment":15},{"nctId":"NCT02938286","phase":"PHASE4","title":"Fractional Laser Assisted Delivery of Anesthetics III","status":"COMPLETED","sponsor":"Netherlands Institute for Pigment Disorders","startDate":"2016-03","conditions":"Local Anesthesia of the Skin","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ultracain D-S forte","Articaine hydrochloride 40 mg/ml + epinephrine 10 μg/ml"],"phase":"marketed","status":"active","brandName":"AHES 15 minutes","genericName":"AHES 15 minutes","companyName":"Netherlands Institute for Pigment Disorders","companyId":"netherlands-institute-for-pigment-disorders","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AHES 15 minutes is a topical treatment designed to rapidly improve skin pigmentation disorders through accelerated melanin production or transfer. Used for Pigmentation disorders (vitiligo, hypopigmentation, or related conditions).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}