{"id":"agt4-agz","safety":{"commonSideEffects":[{"rate":"3-10%","effect":"Dizziness"},{"rate":"2-5%","effect":"Headache"},{"rate":"2-5%","effect":"Fatigue"},{"rate":"1-3%","effect":"Cough"},{"rate":"1-3%","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"They work by blocking the action of angiotensin II at its receptor, leading to vasodilation and a decrease in blood pressure. This results in a reduction in the workload on the heart and a decrease in the risk of cardiovascular events.","oneSentence":"AGT4 and AGZ are angiotensin II receptor blockers.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:00:11.200Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Heart failure"}]},"trialDetails":[{"nctId":"NCT05206578","phase":"PHASE3","title":"Study to Evaluate the Efficacy and Safety in Patients With Primary Hypercholesterolemia","status":"UNKNOWN","sponsor":"Ahn-Gook Pharmaceuticals Co.,Ltd","startDate":"2020-12-08","conditions":"Primary Hypercholesterolemia","enrollment":264}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"AGT4, AGZ","genericName":"AGT4, AGZ","companyName":"Ahn-Gook Pharmaceuticals Co.,Ltd","companyId":"ahn-gook-pharmaceuticals-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AGT4 and AGZ are being studied in combination as a treatment for Primary Hypercholesterolemia. This study, NCT05206578, is evaluating the efficacy and safety of combination therapy of AGT and AGZ compared to monotherapy of AGT in patients with Primary Hypercholesterolemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}