{"id":"agrippal-s1","safety":{"commonSideEffects":[{"rate":"10-40","effect":"Injection site reactions (pain, redness, swelling)"},{"rate":"5-15","effect":"Myalgia"},{"rate":"5-10","effect":"Headache"},{"rate":"1-5","effect":"Fever"},{"rate":"5-10","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL4112960","moleculeType":"Small molecule","molecularWeight":"459.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains inactivated (killed) influenza virus antigens from three seasonal strains, which trigger both humoral and cellular immune responses. This leads to the production of protective antibodies and memory immune cells that recognize and neutralize circulating influenza viruses, reducing infection risk and disease severity.","oneSentence":"Agrippal S1 is an inactivated influenza vaccine that stimulates the immune system to produce antibodies against seasonal influenza virus strains.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:00:11.606Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seasonal influenza prevention in adults and children"}]},"trialDetails":[{"nctId":"NCT02621177","phase":"PHASE3","title":"Study of Egg-derived Influenza Vaccine and Cell Culture-derived Influenza Vaccine in Healthy Children and Adolescents","status":"COMPLETED","sponsor":"SK Chemicals Co., Ltd.","startDate":"2013-11","conditions":"Influenza, Human","enrollment":385},{"nctId":"NCT02621164","phase":"PHASE3","title":"Immunogenicity and Safety of Quadrivalent Influenza Vaccine in Children and Adolescents","status":"COMPLETED","sponsor":"SK Chemicals Co., Ltd.","startDate":"2014-09","conditions":"Influenza, Human","enrollment":454},{"nctId":"NCT02344134","phase":"PHASE3","title":"Study of Egg-derived Influenza Vaccine and Cell Culture-derived Influenza Vaccine in Adult and Elderly Subjects","status":"COMPLETED","sponsor":"SK Chemicals Co., Ltd.","startDate":"2013-09","conditions":"Influenza, Human","enrollment":1155},{"nctId":"NCT01151059","phase":"PHASE2","title":"Safety and Immunogenicity of One Dose of Inactivated Trivalent Flu Vaccine Administered to Non-elderly Adult and Elderly Subjects","status":"COMPLETED","sponsor":"Novartis Vaccines","startDate":"2010-06","conditions":"Seasonal Influenza","enrollment":138},{"nctId":"NCT01002716","phase":"PHASE4","title":"Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis","status":"UNKNOWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2009-10","conditions":"Rheumatoid Arthritis","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Agrippal S1","genericName":"Agrippal S1","companyName":"SK Chemicals Co., Ltd.","companyId":"sk-chemicals-co-ltd","modality":"Biologic","firstApprovalDate":"","aiSummary":"Agrippal S1 is a small molecule used in a trivalent subunit inactivated flu vaccine. It has been studied for its safety and immunogenicity in treating Seasonal Influenza, Influenza, and Rheumatoid Arthritis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}