{"id":"agn-223575-ophthalmic-solution","safety":{"commonSideEffects":[{"rate":"null","effect":"Eye irritation"}]},"_chembl":{"chemblId":"CHEMBL4303670","moleculeType":"Small molecule","molecularWeight":"424.57"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"AGN-223575 ophthalmic solution works by suppressing the immune system's response to inflammation in the eye, thereby reducing swelling and pain. This is achieved through the inhibition of phospholipase A2, a key enzyme involved in the inflammatory process. By reducing inflammation, AGN-223575 ophthalmic solution helps to promote healing and prevent further damage to the eye.","oneSentence":"AGN-223575 ophthalmic solution is a corticosteroid used to treat inflammation in the eye.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:20:11.420Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of inflammation in the eye"}]},"trialDetails":[{"nctId":"NCT02435914","phase":"PHASE2","title":"Safety, Efficacy, Tolerability and Pharmacokinetics of AGN-223575 Ophthalmic Suspension in Patients With Dry Eye Disease","status":"COMPLETED","sponsor":"Allergan","startDate":"2015-06","conditions":"Dry Eye Syndromes","enrollment":236}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"AGN-223575 ophthalmic solution","genericName":"AGN-223575 ophthalmic solution","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AGN-223575 ophthalmic solution is a corticosteroid used to treat inflammation in the eye. Used for Treatment of inflammation in the eye.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}