{"id":"agn-195263-0-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Iris pigmentation changes"},{"rate":null,"effect":"Eyelash growth"},{"rate":null,"effect":"Eye irritation"}]},"_chembl":{"chemblId":"CHEMBL4303670","moleculeType":"Small molecule","molecularWeight":"424.57"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"AGN-195263 is a selective prostaglandin F (FP) receptor agonist formulated as a 0.1% ophthalmic solution. It increases uveoscleral outflow of aqueous humor, thereby reducing intraocular pressure. This mechanism is typical of prostaglandin analogs used in glaucoma and ocular hypertension management.","oneSentence":"AGN-195263 is a topical ophthalmic agent that modulates intraocular pressure through enhanced aqueous humor outflow.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:21:18.171Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT01633788","phase":"PHASE2","title":"A Study of AGN-195263 for the Treatment of Meibomian Gland Dysfunction","status":"COMPLETED","sponsor":"Allergan","startDate":"2012-08-22","conditions":"Meibomian Gland Dysfunction","enrollment":232}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":400454,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"AGN-195263 0.1%","genericName":"AGN-195263 0.1%","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AGN-195263 is a topical ophthalmic agent that modulates intraocular pressure through enhanced aqueous humor outflow. Used for Glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}