{"id":"agn-190584-ophthalmic-solution","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Eye irritation"},{"rate":"5-10%","effect":"Blurred vision"},{"rate":"5-10%","effect":"Eye dryness"}]},"_chembl":{"chemblId":"CHEMBL4303670","moleculeType":"Small molecule","molecularWeight":"424.57"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"AGN-190584 ophthalmic solution works by suppressing the immune system's response to inflammation in the eye, thereby reducing swelling and pain. This is achieved through the inhibition of phospholipase A2, a key enzyme involved in the inflammatory process. By reducing inflammation, AGN-190584 ophthalmic solution helps to promote healing and reduce discomfort in the affected eye.","oneSentence":"AGN-190584 ophthalmic solution is a corticosteroid used to treat inflammation in the eye.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:20:11.427Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of inflammation and pain in the eye"}]},"trialDetails":[{"nctId":"NCT04837482","phase":"PHASE3","title":"A Study to Assess the Impact and Adverse Events of Topical Eyedrops of AGN-190584 on Night-driving Performance in Participants, 40 to 55 Years of Age","status":"COMPLETED","sponsor":"AbbVie","startDate":"2021-05-14","conditions":"Presbyopia","enrollment":43},{"nctId":"NCT04983589","phase":"PHASE3","title":"A Study to Assess Safety and Efficacy in Participants Age 40 to 55 With Presbyopia (Old Eye) Who Receive AGN-190584 in Both Eyes Twice Daily","status":"COMPLETED","sponsor":"Allergan","startDate":"2021-09-02","conditions":"Presbyopia","enrollment":230},{"nctId":"NCT05393089","phase":"PHASE2","title":"Study of AGN-190584 Eye Drops to Assess Safety and Efficacy in Participants Aged 40-80 Years With Pseudophakic Presbyopia","status":"WITHDRAWN","sponsor":"Allergan","startDate":"2022-06-09","conditions":"Presbyopia","enrollment":""},{"nctId":"NCT03857542","phase":"PHASE3","title":"A Phase 3 Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With Presbyopia","status":"COMPLETED","sponsor":"Allergan","startDate":"2019-03-01","conditions":"Presbyopia","enrollment":427},{"nctId":"NCT03804268","phase":"PHASE3","title":"Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With Presbyopia","status":"COMPLETED","sponsor":"Allergan","startDate":"2018-12-21","conditions":"Presbyopia","enrollment":323},{"nctId":"NCT02595528","phase":"PHASE2","title":"A Study of the Concurrent Use of AGN-190584 and AGN-199201 in Participants With Presbyopia","status":"COMPLETED","sponsor":"Allergan","startDate":"2016-04-29","conditions":"Presbyopia","enrollment":163},{"nctId":"NCT02780115","phase":"PHASE2","title":"A Safety, Efficacy and Pharmacokinetic Study of AGN-199201 and AGN-190584 in Patients With Presbyopia","status":"COMPLETED","sponsor":"Allergan","startDate":"2016-05-26","conditions":"Presbyopia","enrollment":151},{"nctId":"NCT02197806","phase":"PHASE2","title":"Safety and Efficacy of AGN-199201 and AGN-190584 in Patients With Presbyopia","status":"COMPLETED","sponsor":"Allergan","startDate":"2014-07","conditions":"Presbyopia","enrollment":65}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"AGN-190584 ophthalmic solution","genericName":"AGN-190584 ophthalmic solution","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AGN-190584 ophthalmic solution is a corticosteroid used to treat inflammation in the eye. Used for Treatment of inflammation and pain in the eye.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}