{"id":"afloqualone","rwe":[{"pmid":"34061550","year":"2021","title":"Unexpected Insertion of Nitrogen into a C-C Bond: Access to 2,3-Disubstituted Quinazolinone Scaffolds.","finding":"","journal":"Organic letters","studyType":"Clinical Study"},{"pmid":"32815004","year":"2021","title":"In vitro assessment of the photo(geno)toxicity associated with Lapatinib, a Tyrosine Kinase inhibitor.","finding":"","journal":"Archives of toxicology","studyType":"Clinical Study"},{"pmid":"30809878","year":"2019","title":"Coma and seizure caused by an afloqualone overdose.","finding":"","journal":"Pediatrics international : official journal of the Japan Pediatric Society","studyType":"Clinical Study"},{"pmid":"30175093","year":"2018","title":"Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids.","finding":"","journal":"Frontiers in chemistry","studyType":"Clinical Study"},{"pmid":"29142147","year":"2018","title":"Accidental afloqualone intoxication in two dogs.","finding":"","journal":"The Journal of veterinary medical science","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Dermatologic Agents","category":"pharmacology"},{"label":"Muscle Relaxants, Central","category":"pharmacology"},{"label":"Neuromuscular Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Photosensitizing Agents","category":"pharmacology"},{"label":"Radiation-Sensitizing Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"aroft","offLabel":[],"synonyms":["afloqualone","aroft","arofuto"],"timeline":[],"brandName":"Aroft","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Think of Aroft like a key that fits into a lock. The lock is a specific target in the body, and when the key (Aroft) binds to it, it can help to turn off or turn on certain processes that are involved in the development of a disease. However, since the target and mechanism of action are unknown, it's like trying to find the right key without knowing what the lock looks like.","oneSentence":"Aroft works by binding to a specific target, although its exact mechanism of action is currently unknown.","technicalDetail":"Aroft's mechanism of action is likely to involve the modulation of a specific protein or receptor, although the exact molecular details are currently unclear."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/98","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AFLOQUALONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:30:17.368114","biosimilars":[],"competitors":[],"genericName":"afloqualone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"010869","UNII":"CO4U2C8ORZ","CHEBI":"CHEBI:31177","INN_ID":"4831","UMLSCUI":"C0050939","ChEMBL_ID":"CHEMBL2105918","KEGG_DRUG":"D01638","PUBCHEM_CID":"2040","MESH_SUPPLEMENTAL_RECORD_UI":"C033541"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":35,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2021 Jun 18","pmid":"34061550","title":"Unexpected Insertion of Nitrogen into a C-C Bond: Access to 2,3-Disubstituted Quinazolinone Scaffolds.","journal":"Organic letters"},{"date":"2021 Jan","pmid":"32815004","title":"In vitro assessment of the photo(geno)toxicity associated with Lapatinib, a Tyrosine Kinase inhibitor.","journal":"Archives of toxicology"},{"date":"2019 Feb","pmid":"30809878","title":"Coma and seizure caused by an afloqualone overdose.","journal":"Pediatrics international : official journal of the Japan Pediatric Society"},{"date":"2018","pmid":"30175093","title":"Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids.","journal":"Frontiers in chemistry"},{"date":"2018 Feb 2","pmid":"29142147","title":"Accidental afloqualone intoxication in two dogs.","journal":"The Journal of veterinary medical science"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aroft (AFLOQUALONE) is a small molecule modality with unknown target and drug class. Its commercial status is unclear, and it has not been approved by the FDA for any indications. As a result, there is limited information available on its pharmacokinetic properties, such as half-life and bioavailability. Aroft's safety profile and potential side effects are also unknown. Further research is needed to determine its efficacy and potential therapeutic applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}