{"id":"aesculus-hippocastanum-and-associations","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The extract contains aescin, a triterpene saponin that decreases inflammatory mediator release and strengthens the integrity of blood vessel walls. This mechanism reduces edema and improves blood flow in venous insufficiency. The compound also has antioxidant properties that contribute to its anti-inflammatory effects.","oneSentence":"Aesculus hippocastanum (horse chestnut seed extract) reduces inflammation and improves venous tone through its active constituent aescin, which stabilizes capillary membranes and reduces vascular permeability.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:20:18.861Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic venous insufficiency"},{"name":"Varicose veins"},{"name":"Hemorrhoids"},{"name":"Lymphedema"}]},"trialDetails":[{"nctId":"NCT06579482","phase":"PHASE4","title":"Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous Insuficiency","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2024-11-06","conditions":"Chronic Venous Insufficiency","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["no other intervention names"],"phase":"marketed","status":"active","brandName":"Aesculus hippocastanum, and associations","genericName":"Aesculus hippocastanum, and associations","companyName":"Fundação Educacional Serra dos Órgãos","companyId":"funda-o-educacional-serra-dos-rg-os","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aesculus hippocastanum (horse chestnut seed extract) reduces inflammation and improves venous tone through its active constituent aescin, which stabilizes capillary membranes and reduces vascular permeability. Used for Chronic venous insufficiency, Varicose veins, Hemorrhoids.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}