{"id":"aerosolized-tobramycin-or-vancomycin","safety":{"commonSideEffects":[{"rate":null,"effect":"Bronchospasm"},{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Wheezing"},{"rate":null,"effect":"Voice hoarseness"},{"rate":null,"effect":"Tinnitus (tobramycin)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tobramycin and vancomycin are broad-spectrum antibiotics that inhibit bacterial protein synthesis (tobramycin) or cell wall synthesis (vancomycin). When aerosolized, they bypass systemic absorption and deliver high drug concentrations directly to infected lung tissue, particularly useful for chronic respiratory infections in cystic fibrosis and other conditions where systemic dosing may be limited by toxicity or poor lung penetration.","oneSentence":"Aerosolized aminoglycoside or glycopeptide antibiotics are inhaled directly into the lungs to achieve high local concentrations that kill susceptible bacteria in respiratory infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:26:56.007Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic Pseudomonas aeruginosa respiratory infection in cystic fibrosis patients"},{"name":"Chronic respiratory infections in non-cystic fibrosis bronchiectasis"}]},"trialDetails":[{"nctId":"NCT02478710","phase":"PHASE4","title":"Aerosolized Antibiotics in the Treatment of Ventilator Associated Pneumonia","status":"TERMINATED","sponsor":"Wright State University","startDate":"2015-06","conditions":"Pneumonia, Ventilator-Associated","enrollment":16}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":39778,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tobi, Tobrex; Vancocin"],"phase":"marketed","status":"active","brandName":"Aerosolized Tobramycin or Vancomycin","genericName":"Aerosolized Tobramycin or Vancomycin","companyName":"Wright State University","companyId":"wright-state-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aerosolized aminoglycoside or glycopeptide antibiotics are inhaled directly into the lungs to achieve high local concentrations that kill susceptible bacteria in respiratory infections. Used for Chronic Pseudomonas aeruginosa respiratory infection in cystic fibrosis patients, Chronic respiratory infections in non-cystic fibrosis bronchiectasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}