{"id":"aerosol-inhaled-amikacin-sulfate-injection","safety":{"commonSideEffects":[{"rate":"null","effect":"Ototoxicity"},{"rate":"null","effect":"Nephrotoxicity"},{"rate":"null","effect":"Hypokalemia"}]},"_chembl":{"chemblId":"CHEMBL4208954","moleculeType":"Small molecule","molecularWeight":"781.77"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Amikacin Sulfate Injection is an aminoglycoside antibiotic that binds to the 30S ribosomal subunit of bacteria, thereby inhibiting protein synthesis and ultimately leading to bacterial cell death.","oneSentence":"Amikacin Sulfate Injection works by inhibiting bacterial protein synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:00:07.837Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of complicated urinary tract infections, including pyelonephritis"}]},"trialDetails":[{"nctId":"NCT03449459","phase":"EARLY_PHASE1","title":"Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract","status":"COMPLETED","sponsor":"Shanghai Zhongshan Hospital","startDate":"2018-12-01","conditions":"Chronic Obstructive Pulmonary Disease (COPD)","enrollment":144},{"nctId":"NCT05213507","phase":"PHASE3","title":"Inhaled Amikacin in Preventing AECOPD","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2022-03","conditions":"COPD, COPD Exacerbation","enrollment":136}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Aerosol Inhaled investigation drug"],"phase":"phase_3","status":"active","brandName":"aerosol inhaled Amikacin Sulfate Injection","genericName":"aerosol inhaled Amikacin Sulfate Injection","companyName":"Shanghai Zhongshan Hospital","companyId":"shanghai-zhongshan-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amikacin Sulfate Injection works by inhibiting bacterial protein synthesis. Used for Treatment of complicated urinary tract infections, including pyelonephritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}