{"id":"advil-pm-liqui-gels","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Gastrointestinal upset"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ibuprofen works by inhibiting the enzyme cyclooxygenase-2 (COX-2), which is involved in the production of prostaglandins, leading to pain relief and reduced inflammation.","oneSentence":"Ibuprofen is a non-selective COX-2 inhibitor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T05:50:54.977Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relief of mild to moderate pain"},{"name":"Reduction of inflammation"}]},"trialDetails":[{"nctId":"NCT05674721","phase":"PHASE1","title":"A Bioequivalence Study of Advil PM Liqui-Gels Minis (Ibuprofen/Diphenhydramine Hydrochloride 200 mg/25 mg) Compared to the Current Marketed Advil PM Liqui-Gels (Ibuprofen/Diphenhydramine Hydrochloride 200 mg/25 mg) in Healthy Adult Subjects Under Fasted Conditions","status":"COMPLETED","sponsor":"HALEON","startDate":"2023-01-05","conditions":"Pain","enrollment":77},{"nctId":"NCT01118273","phase":"PHASE4","title":"Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-01","conditions":"Sleep","enrollment":162},{"nctId":"NCT01053338","phase":"PHASE1","title":"Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fed Condition","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2008-04","conditions":"Healthy","enrollment":40},{"nctId":"NCT01053208","phase":"PHASE1","title":"Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2008-04","conditions":"Healthy","enrollment":40}],"_emaApprovals":[],"_faersSignals":[{"count":4,"reaction":"FALL"},{"count":2,"reaction":"CEREBROVASCULAR ACCIDENT"},{"count":2,"reaction":"DRUG INEFFECTIVE"},{"count":2,"reaction":"HYPOAESTHESIA"},{"count":2,"reaction":"PRURITUS"},{"count":2,"reaction":"WEIGHT INCREASED"},{"count":1,"reaction":"ABDOMINAL PAIN UPPER"},{"count":1,"reaction":"ALLERGY TO ARTHROPOD STING"},{"count":1,"reaction":"ARTHRALGIA"},{"count":1,"reaction":"ARTHROPOD STING"}],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"Advil PM Liqui-Gels","genericName":"Advil PM Liqui-Gels","companyName":"HALEON","companyId":"haleon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ibuprofen is a non-selective COX-2 inhibitor. Used for Relief of mild to moderate pain, Reduction of inflammation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}