{"id":"advanced-eye-relief","safety":{"commonSideEffects":[{"rate":null,"effect":"Temporary stinging or burning"},{"rate":null,"effect":"Rebound redness with prolonged use"},{"rate":null,"effect":"Mydriasis or blurred vision"}]},"_chembl":null,"_dailymed":{"setId":"5c5d6c13-9b51-48f0-8627-b60b0f707fd3","title":"LEADER ADVANCED RELIEF EYE DROPS (DEXTRAN 70, POLYETHYLENE GLYCOL 400, POVIDONE, TETRAHYDROZOLINE HCL) SOLUTION/ DROPS [CARDINAL HEALTH]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The product combines lubricating agents (typically polyethylene glycol or similar demulcents) to coat and hydrate the cornea and conjunctiva, along with a decongestant component (likely naphazoline or similar alpha-adrenergic agonist) that causes vasoconstriction of conjunctival blood vessels to reduce visible redness. This dual mechanism addresses both the dryness and hyperemia associated with minor eye irritation.","oneSentence":"Advanced Eye Relief is an over-the-counter ophthalmic lubricant and decongestant that reduces eye redness and irritation by moisturizing the ocular surface and constricting blood vessels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:21:06.361Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Minor eye irritation and redness"},{"name":"Dry eye symptoms"},{"name":"Eye discomfort from environmental factors"}]},"trialDetails":[{"nctId":"NCT06971016","phase":"NA","title":"\"Effectiveness of Mulligan Mobilization Technique and Proprioceptive Exercises Among Patients With Knee Osteoarthritis\"","status":"RECRUITING","sponsor":"National Healthcare Center","startDate":"2025-03-27","conditions":"Knee Osteoarthritis","enrollment":60},{"nctId":"NCT00697541","phase":"PHASE2","title":"Systemic Bioavailability Study Of Col-118 Administered Topically as a 0.18 % Facial Gel And Brimonidine Ophthalmic Solution 0.2%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2008-05","conditions":"Erythematous Rosacea","enrollment":20},{"nctId":"NCT01456780","phase":"PHASE4","title":"Efficacy of Zylet vs. Lotemax for the Treatment of Ocular Surface Inflammation/MGD/Blepharitis","status":"COMPLETED","sponsor":"Massachusetts Eye and Ear Infirmary","startDate":"2011-08","conditions":"Meibomian Gland Dysfunction, Posterior Blepharitis","enrollment":60}],"_emaApprovals":[],"_faersSignals":[{"count":30,"reaction":"EYE IRRITATION"},{"count":17,"reaction":"EYE PAIN"},{"count":14,"reaction":"OCULAR HYPERAEMIA"},{"count":10,"reaction":"DRUG INEFFECTIVE"},{"count":9,"reaction":"VISION BLURRED"},{"count":8,"reaction":"EYE PRURITUS"},{"count":7,"reaction":"CONDITION AGGRAVATED"},{"count":7,"reaction":"ERYTHEMA"},{"count":6,"reaction":"LACRIMATION INCREASED"},{"count":5,"reaction":"EXPIRED PRODUCT ADMINISTERED"}],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Advanced Eye Relief","genericName":"Advanced Eye Relief","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Advanced Eye Relief is an over-the-counter ophthalmic lubricant and decongestant that reduces eye redness and irritation by moisturizing the ocular surface and constricting blood vessels. Used for Minor eye irritation and redness, Dry eye symptoms, Eye discomfort from environmental factors.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}