{"id":"adstem-inj","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Transient fever"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ADSTEM consists of cultured mesenchymal stem cells derived from human adipose tissue, which are administered via injection to damaged or diseased tissues. These cells are believed to work through multiple mechanisms including direct differentiation into tissue-specific cells, paracrine secretion of anti-inflammatory and growth factors, and immunomodulation to reduce pathological inflammation and promote tissue repair.","oneSentence":"ADSTEM is an allogeneic adipose-derived mesenchymal stem cell therapy that promotes tissue regeneration and modulates immune responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:17.985Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis (knee)"},{"name":"Cartilage defects"}]},"trialDetails":[{"nctId":"NCT07377838","phase":"PHASE3","title":"Study of ADSTEM Injection for Patients With Moderate to Severe Subacute and Chronic Atopic Dermatitis","status":"NOT_YET_RECRUITING","sponsor":"EHL Bio Co., Ltd.","startDate":"2026-06","conditions":"Atopic Dermatitis","enrollment":286},{"nctId":"NCT06893250","phase":"PHASE2, PHASE3","title":"Orthobiologic Treatment for Knee Osteoarthritis","status":"ENROLLING_BY_INVITATION","sponsor":"University Hospital of North Norway","startDate":"2024-09-23","conditions":"Osteoarthritis Knee","enrollment":160},{"nctId":"NCT04137562","phase":"PHASE2","title":"Safety and Efficacy in Patients With Moderate to Severe Subacute and Chronic Atopic Dermatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"EHL Bio Co., Ltd.","startDate":"2019-12-11","conditions":"Atopic Dermatitis","enrollment":118},{"nctId":"NCT03252340","phase":"","title":"Safety of ADSTEM Injection in Patients With Moderate to Severe Subacute and Chronic Atopic Dermatitis","status":"COMPLETED","sponsor":"EHL Bio Co., Ltd.","startDate":"2017-09-19","conditions":"Atopic Dermatitis","enrollment":11},{"nctId":"NCT02888704","phase":"PHASE1","title":"Safety and Efficacy of ADSTEM Inj. in Patients With Moderately Subacute and Chronic Atopic Dermatitis","status":"COMPLETED","sponsor":"EHL Bio Co., Ltd.","startDate":"2016-07","conditions":"Atopic Dermatitis","enrollment":13}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"ADSTEM Inj.","genericName":"ADSTEM Inj.","companyName":"EHL Bio Co., Ltd.","companyId":"ehl-bio-co-ltd","modality":"Biologic","firstApprovalDate":"","aiSummary":"ADSTEM is an allogeneic adipose-derived mesenchymal stem cell therapy that promotes tissue regeneration and modulates immune responses. Used for Osteoarthritis (knee), Cartilage defects.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}