{"id":"adrenaline-nasal-pack","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Palpitations"},{"rate":"5-10%","effect":"Tremors"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL42280","moleculeType":"Small molecule","molecularWeight":"183.21"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Adrenaline, also known as epinephrine, is a potent stimulant that increases heart rate, blood pressure, and breathing rate. When administered via a nasal pack, it quickly reaches the bloodstream and helps to counteract the life-threatening symptoms of anaphylaxis, such as difficulty breathing and rapid heartbeat.","oneSentence":"Adrenaline nasal pack works by releasing adrenaline into the nasal passages to rapidly increase blood pressure and improve breathing in cases of anaphylaxis or severe allergic reactions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:19:50.131Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anaphylaxis treatment"}]},"trialDetails":[{"nctId":"NCT07421622","phase":"NA","title":"Management of Epistaxis Comparing Nasal Packing Versus Greater Palatine Foramen Block","status":"NOT_YET_RECRUITING","sponsor":"Sheikh Zayed Federal Postgraduate Medical Institute","startDate":"2026-03-01","conditions":"Epistaxis Nosebleed, Greater Palatine Foramen","enrollment":40},{"nctId":"NCT06920368","phase":"NA","title":"Different Techniques for Prevention of Complications After Septoplasty Operation","status":"RECRUITING","sponsor":"Tanta University","startDate":"2024-05-01","conditions":"Septoplasty","enrollment":90},{"nctId":"NCT06838377","phase":"NA","title":"Accuracy of Computer Guided Screw Holes Locating Guide and Patient Specific Champy Plate vs Conventional Champy Plate Osteosynthesis in Management of Mandibular Angle Fracture: Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-02-25","conditions":"Mandible Fracture","enrollment":20},{"nctId":"NCT06801522","phase":"PHASE2, PHASE3","title":"Adrenaline Nasal Pack vs Xylometazoline Nasal Drops During Nasotracheal Intubation","status":"RECRUITING","sponsor":"Shaheed Mohtarma Benazir Bhutto Institue of Trauma","startDate":"2024-12-01","conditions":"Nasal Bleeding, Nasotracheal Intubation","enrollment":70},{"nctId":"NCT05507476","phase":"NA","title":"Nasal Desmopressin Versus Topical Epinephrine in Endonasal Dacryocystorhinostomy","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2022-09-01","conditions":"Anesthesia","enrollment":52},{"nctId":"NCT05930132","phase":"NA","title":"The Role of the Submucosal Conchoplasty Technique in Improving the Postoperative Middle Meatus Outcome After ESS","status":"COMPLETED","sponsor":"Kafrelsheikh University","startDate":"2018-10-01","conditions":"Endoscopic Sinus Surgery","enrollment":56},{"nctId":"NCT03427502","phase":"NA","title":"Anterior Ethmoidal Nerve Block in Prevention of Postoperative Agitation","status":"COMPLETED","sponsor":"Lumbini Medical College","startDate":"2018-06-01","conditions":"Postoperative Agitation: Impaired Awareness, Abnormal Cognitive Function, Confusion, and Verbal and Physical Agitation During Recovery From General Anesthesia, Deviated Nasal Septum, Chronic Rhinosinusitis (Diagnosis)","enrollment":100},{"nctId":"NCT01785173","phase":"NA","title":"Endoscopic-guided Versus Cotton-tipped Applicator Gauze Pledgetting for Nasal Anesthesia Before Transnasal Endoscopy","status":"UNKNOWN","sponsor":"Buddhist Tzu Chi General Hospital","startDate":"2012-10","conditions":"Methods of Nasal Anesthesia Before Transnasal Endoscopy, Side Effects of Transnasal Endoscopy, Patient's Tolerance to Transnasal Endoscopy","enrollment":242}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Adrenaline nasal pack","genericName":"Adrenaline nasal pack","companyName":"Shaheed Mohtarma Benazir Bhutto Institue of Trauma","companyId":"shaheed-mohtarma-benazir-bhutto-institue-of-trauma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Adrenaline nasal packs are used in nasal surgeries, such as septoplasty, to prevent postoperative agitation. The mechanism of adrenaline nasal packs is through the action of adrenaline as a small molecule, although the specific details of its mechanism are not provided in the available information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}