{"id":"adjuvants-anesthesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Delayed recovery"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Anesthetic adjuvants are drugs administered alongside primary anesthetics to potentiate anesthetic effects, reduce side effects, or provide complementary actions. Common adjuvants include opioids for analgesia, benzodiazepines for anxiolysis and sedation, and neuromuscular blocking agents for muscle relaxation. By combining agents with different mechanisms, adjuvants allow lower doses of each drug, thereby reducing toxicity and adverse effects while achieving optimal anesthetic conditions.","oneSentence":"Adjuvants in anesthesia enhance or modify the effects of primary anesthetic agents to improve anesthetic depth, reduce required doses, and provide additional therapeutic benefits such as analgesia or muscle relaxation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:44:16.989Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adjunctive use in general anesthesia to enhance anesthetic efficacy and reduce primary anesthetic requirements"},{"name":"Perioperative analgesia and anxiolysis"}]},"trialDetails":[{"nctId":"NCT07294352","phase":"NA","title":"Comparison of Intrathecal Nalbuphine Versus Intrathecal Tramadol as Adjuvants in Subarachnoid Block for Lower Limb Orthopaedic Surgeries","status":"ACTIVE_NOT_RECRUITING","sponsor":"CMH Lahore Medical 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Used for Adjunctive use in general anesthesia to enhance anesthetic efficacy and reduce primary anesthetic requirements, Perioperative analgesia and anxiolysis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}