{"id":"adjuvant-analgesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness/sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL4650400","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adjuvant analgesics are a diverse class of drugs not primarily designed as painkillers but that possess analgesic properties when combined with opioids or other primary analgesics. They work through multiple mechanisms including norepinephrine and serotonin reuptake inhibition, sodium channel blockade, GABA enhancement, or NMDA receptor antagonism, thereby potentiating pain relief and reducing the required doses of primary analgesics.","oneSentence":"Adjuvant analgesics are medications that enhance pain relief when used alongside primary analgesics, working through various mechanisms including modulation of neurotransmitters and pain pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:19:17.679Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain when used adjunctively with primary analgesics"},{"name":"Neuropathic pain"},{"name":"Cancer pain"}]},"trialDetails":[{"nctId":"NCT07292324","phase":"PHASE4","title":"Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy","status":"COMPLETED","sponsor":"Udayana University","startDate":"2025-08-21","conditions":"Post Operative Pain, Acute, Chronic Post Surgical Pain, Gynecologic Disease","enrollment":62},{"nctId":"NCT07485127","phase":"EARLY_PHASE1","title":"Comparison Between Dexamethasone and Dexmedetomidine in Spinal Anesthesia for Cases With Fracture Pelvis Fixation","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sohag University","startDate":"2026-02-08","conditions":"Fracture Pelvis","enrollment":60},{"nctId":"NCT07474506","phase":"","title":"From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma","status":"NOT_YET_RECRUITING","sponsor":"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)","startDate":"2026-03-15","conditions":"Pain Management, Perioperative Analgesia, War-Related Injuries","enrollment":150},{"nctId":"NCT07330999","phase":"NA","title":"Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-13","conditions":"Hip Osteoarthritis","enrollment":120},{"nctId":"NCT07327372","phase":"NA","title":"PENG Block With Dexmedetomidine in Older Adults","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-06","conditions":"Hip Osteoarthritis, Arthropathy of Hip","enrollment":30},{"nctId":"NCT05947760","phase":"PHASE4","title":"Magnesium as an Adjuvant Agent for Postoperative Pain","status":"RECRUITING","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2025-03-10","conditions":"Pain, Postoperative","enrollment":64},{"nctId":"NCT07424599","phase":"NA","title":"Effect of Dexmedetomidine Versus Dexamethasone as Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block on Postoperative Analgesia in Myasthenic Patients Undergoing Thoracoscopic Thymectomy","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-03-15","conditions":"Postoperative Pain, Acute","enrollment":60},{"nctId":"NCT06453681","phase":"PHASE4","title":"Dexmedetomidine as an Adjuvant to Bupivacaine in Bilateral PECs for Pain Control After Cardiac Surgeries","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2024-08-01","conditions":"Post Operative Pain","enrollment":60},{"nctId":"NCT07395999","phase":"","title":"Effectiveness of Pain Management Interventions in Patients With Chronic Cancer Pain","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2025-11-14","conditions":"Chronic Cancer Pain, Pain Management","enrollment":134},{"nctId":"NCT07412223","phase":"PHASE4","title":"Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xiangya Hospital of Central South University","startDate":"2026-02-24","conditions":"Pain, Postoperative, Postoperative Ileus","enrollment":152},{"nctId":"NCT05785377","phase":"NA","title":"Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Mansoura University","startDate":"2027-12-01","conditions":"Analgesia","enrollment":58},{"nctId":"NCT07382973","phase":"NA","title":"Safety and Efficacy of NTP in Thyroid Surgery: Pilot Study on Morbidity Prevention and Adjuvant Oncological Control","status":"RECRUITING","sponsor":"National Institute of Nuclear Research - Mexico","startDate":"2025-08-20","conditions":"Thyroid Diseases, Wound Healing, Thyroidectomy","enrollment":26},{"nctId":"NCT07380139","phase":"PHASE1","title":"Dexamethasone vs Dexmedetomidine in Sphenopalatine Ganglion Block for Rhinoplasty Pain","status":"ENROLLING_BY_INVITATION","sponsor":"Ain Shams University","startDate":"2026-02-01","conditions":"Post Operative Pain","enrollment":90},{"nctId":"NCT07289620","phase":"NA","title":"Dexamethasone vs Dexmedetomidine vs Combination as Adjuvants to Popliteal Sciatic Nerve Block in Children","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-01-16","conditions":"Ankle Disease, Foot Diseases","enrollment":120},{"nctId":"NCT07342790","phase":"NA","title":"Artificial Intelligence Clinical Decision","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2026-02-01","conditions":"Myofacial Pain Syndrome, Clinical Decision Support","enrollment":70},{"nctId":"NCT07306702","phase":"PHASE4","title":"Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients","status":"COMPLETED","sponsor":"Shenyang Sixth People's Hospital","startDate":"2023-07-01","conditions":"Postoperative Pain Management","enrollment":102},{"nctId":"NCT06184126","phase":"NA","title":"Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises","status":"RECRUITING","sponsor":"University of Maryland, Baltimore","startDate":"2024-11-01","conditions":"Sickle Cell Disease, Vaso-occlusive Pain Episode in Sickle Cell Disease, Acute Pain","enrollment":30},{"nctId":"NCT07290582","phase":"","title":"Phrenic Infiltration as Cryoanalgesia Adjuvant for Early Postoperative Pain Following the Nuss Procedure","status":"COMPLETED","sponsor":"Papa Giovanni XXIII Hospital","startDate":"2023-09-14","conditions":"Pectus Excavatum, Cryo Analgesia, Phrenic Nerve-related Diaphragmatic Impairment","enrollment":38},{"nctId":"NCT07279727","phase":"PHASE1","title":"Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-01-01","conditions":"Regional Anaesthesia","enrollment":66},{"nctId":"NCT07276906","phase":"PHASE4","title":"Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold (NOA) Block for Bilateral Myringotomy","status":"NOT_YET_RECRUITING","sponsor":"University of South Alabama","startDate":"2026-01","conditions":"Postoperative Pain","enrollment":300},{"nctId":"NCT07241351","phase":"PHASE2, PHASE3","title":"Dexmedetomidine as an Adjunct to Fentanyl for Term Neonates on Mechanical Ventilation","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-03-01","conditions":"Analgesia, Sedation and Analgesia, Neonatal","enrollment":40},{"nctId":"NCT06130670","phase":"NA","title":"Clinical Efficacy and Safety of Dexmedetomidine as an Adjuvant in Quadratus Lumborum Versus Epidural Block in Postoperative Lower Abdominal Cancer Surgeries","status":"COMPLETED","sponsor":"Assiut University","startDate":"2024-04-20","conditions":"To Compare Efficacy of Dexmedetomidine in Bilateral Quadratus Lumborum vs Lumbar Epidural Blocks on Analgesia After Major Lower Abdominal Surgery","enrollment":54},{"nctId":"NCT03263117","phase":"PHASE4","title":"SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-07-01","conditions":"Stroke","enrollment":260},{"nctId":"NCT05976464","phase":"EARLY_PHASE1","title":"Efficacy of Magnesium Sulfate as an Adjuvant in Erector Spinae Plane Block as an Anesthetic Post Operative After Modified Radical Mastectomy","status":"COMPLETED","sponsor":"Assiut University","startDate":"2023-07-15","conditions":"ESPB, Mg Sulfate,Post Mastectomy","enrollment":60},{"nctId":"NCT05671172","phase":"NA","title":"Effect of Adding Hyaluronidase to Bupivacaine in Transversus Abdominis Plane Block for Cesarean Section","status":"COMPLETED","sponsor":"Benha University","startDate":"2023-05-15","conditions":"Pain, Postoperative","enrollment":114},{"nctId":"NCT07139522","phase":"NA","title":"Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia","status":"RECRUITING","sponsor":"Cairo University","startDate":"2023-12-01","conditions":"Dexamethasone, Magnesium Sulphate, Adjuvant","enrollment":150},{"nctId":"NCT07126795","phase":"PHASE1","title":"Magnesium Sulfate in Pediatric Burn Dressing Changes","status":"NOT_YET_RECRUITING","sponsor":"Hennepin Healthcare Research Institute","startDate":"2026-01-01","conditions":"Pediatric Burns","enrollment":10},{"nctId":"NCT07127601","phase":"NA","title":"Comparative Study Between US Guided Erector Spinae and US Guided Cudal Epidural Block","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-01-01","conditions":"Anesthesia, Hernia, Inguinal","enrollment":50},{"nctId":"NCT07117565","phase":"PHASE4","title":"D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary Retention","status":"NOT_YET_RECRUITING","sponsor":"Tribhuvan University Teaching Hospital, Institute Of Medicine.","startDate":"2025-09-15","conditions":"Spinal Anesthesia, Postoperative Complications, Dexmedetomidine","enrollment":190},{"nctId":"NCT07056244","phase":"NA","title":"Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Caudal Epidural Block","status":"RECRUITING","sponsor":"Sohag University","startDate":"2025-06-13","conditions":"İnguinal Hernia","enrollment":80},{"nctId":"NCT06789042","phase":"PHASE4","title":"Dexamethasone for ESPB in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2025-02-01","conditions":"Hip Osteoarthritis, Hip Arthropathy, Hip Arthritis","enrollment":60},{"nctId":"NCT07081581","phase":"PHASE2","title":"Analgesic Effect of Serratus Plane Block With Adjuvant Agents in Breast Cancer Surgery","status":"COMPLETED","sponsor":"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey","startDate":"2022-08-01","conditions":"Breast Cancer, Post Operative Pain","enrollment":75},{"nctId":"NCT07062497","phase":"PHASE2, PHASE3","title":"Clonidine in Ultrasound-guided Rectus Sheath Block for Outpatient Umbilical Hernioplasty","status":"RECRUITING","sponsor":"Universidade Federal do Rio de Janeiro","startDate":"2025-01-07","conditions":"Hernia, Umbilical, Clonidine, Pain, Postoperative","enrollment":62},{"nctId":"NCT06953128","phase":"NA","title":"General Versus Regional Anesthesia in Peripheral Arterial Surgery","status":"NOT_YET_RECRUITING","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2025-07-01","conditions":"Postoperative Complications, Cardiovascular Diseases","enrollment":594},{"nctId":"NCT07024043","phase":"PHASE1, PHASE2","title":"Dexamethasone Versus Dexmedetomidine in IPACK Block to Reduce Pain Post Arthroscopic Knee Surgeries","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-03-03","conditions":"Efficacy of Drugs in Pain Management","enrollment":75},{"nctId":"NCT05688943","phase":"NA","title":"Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES","status":"ENROLLING_BY_INVITATION","sponsor":"University of Kansas Medical Center","startDate":"2023-03-01","conditions":"Anesthesia, Tubal Ligation","enrollment":20},{"nctId":"NCT05997992","phase":"NA","title":"Clinical Efficacy Evaluation of Electroacupuncture as Adjuvant Therapy for Female Patients With Overactive Bladder","status":"RECRUITING","sponsor":"Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation","startDate":"2023-01-11","conditions":"Overactive Bladder","enrollment":100},{"nctId":"NCT06993922","phase":"NA","title":"Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block Versus Bupivacaine Alone for Postoperative Pain Management in Patients Undergoing Craniotomy","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2025-05-29","conditions":"Dexmedetomidine, Adjuvant, Bupivacaine","enrollment":50},{"nctId":"NCT06970548","phase":"NA","title":"Dexamethasone As Adjuvant for Pre - emptiveTransversusAbdominus Muscle Plane Block","status":"COMPLETED","sponsor":"Sohag University","startDate":"2022-06-01","conditions":"Post Operative Pain","enrollment":40},{"nctId":"NCT06969625","phase":"NA","title":"Shoulder Anterior Capsular Block for Postoperative Analgesia in Arthroscopic Rotator Cuff Repair Surgery","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2025-06-01","conditions":"Arthroscopic Rotator Cuff Repair","enrollment":60},{"nctId":"NCT06947330","phase":"PHASE3","title":"Comparison Between Erector Spinae Plane Block Versus Serratus Anterior Plane Block Regarding Analgesia Post Modified Radical Mastectomy","status":"RECRUITING","sponsor":"Kholoud Usama","startDate":"2025-03-03","conditions":"Modified Radical Mastectomy, Breast Cancer","enrollment":100},{"nctId":"NCT06696586","phase":"PHASE4","title":"Comparison Between Effect of Systemic Fentanyl Infusion and Fentanyl Added as An Adjuvant to Lidocaine in Bier Block For Controlling Pain in Patients Undergoing Hand Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-07-01","conditions":"Bier Block, Hand Surgery","enrollment":84},{"nctId":"NCT06653465","phase":"PHASE2, PHASE3","title":"Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery","status":"NOT_YET_RECRUITING","sponsor":"RenJi Hospital","startDate":"2025-06","conditions":"Delirium in Old Age","enrollment":1930},{"nctId":"NCT06888349","phase":"NA","title":"The Effect of Combined IPACK Block with ACB Versus ACB Alone on Pain Management and Early Mobility After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-01-23","conditions":"Postoperative Pain, Motor Activity","enrollment":50},{"nctId":"NCT03662698","phase":"NA","title":"Effect of Guided Imagery for Radiotherapy-Related Distress in Patients With Head and Neck Cancer","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2018-10-12","conditions":"Head and Neck Cancer","enrollment":57},{"nctId":"NCT05824832","phase":"PHASE4","title":"Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery","status":"RECRUITING","sponsor":"Loyola University","startDate":"2023-02-28","conditions":"Pain, Postoperative","enrollment":120},{"nctId":"NCT06764667","phase":"NA","title":"Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor","status":"RECRUITING","sponsor":"Indonesia University","startDate":"2025-02-10","conditions":"Laparoscopic Donor Nephrectomy, Perioperative Pain Management","enrollment":60},{"nctId":"NCT04950660","phase":"PHASE4","title":"Oral Caffeine Use for Pain Management in AIS Patients After Spinal Fusion","status":"COMPLETED","sponsor":"Children's Mercy Hospital Kansas City","startDate":"2019-12-11","conditions":"Adolescent Idiopathic Scoliosis","enrollment":61},{"nctId":"NCT06825286","phase":"NA","title":"Dexmedetomidine as an Adjuvant to Bupivacaine in Ultrasound-Guided Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-08-01","conditions":"Dexmedetomidine, Bupivacaine, Ultrasound-Guided","enrollment":90},{"nctId":"NCT06759116","phase":"NA","title":"Comparison Between Fentanyl and Dexmedetomidine As Adjuvant to Bupivacaine in Combined IPACK and Adductor Canal Block for Postoperative Analgesia After Knee Surgeries","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2025-01-10","conditions":"Analgesia, Postoperative","enrollment":111},{"nctId":"NCT06153602","phase":"NA","title":"Effectiveness of Nalbuphine as an Adjuvant to Subarachnoid Block on Postoperative Analgesia in TURP Surgery","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2023-12-07","conditions":"Transurethral Resection of Prostate","enrollment":80},{"nctId":"NCT06752629","phase":"PHASE4","title":"Comparison Between Dexmedetomidine and Fentanyl As an Adjuvant to Bupivacaine in the Paravertebral Nerve Block in Laparoscopic Cholecystectomy for Postoperative Analgesia: Randomized Comparative Clinical Trial.","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-01-01","conditions":"Laparoscopic Cholecystectomy","enrollment":50},{"nctId":"NCT06746272","phase":"PHASE4","title":"Serratus Planus Block After Minimally Invasive Cardiac Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Medical University of Vienna","startDate":"2023-01-01","conditions":"Pain, Postoperative","enrollment":66},{"nctId":"NCT06738043","phase":"NA","title":"Dexmedetomidine Versus Ketamine as Adjuvants in Bariatric Surgery","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2024-12-20","conditions":"Obesity, Postoperative Pain, Bariatric Surgery","enrollment":90},{"nctId":"NCT06736392","phase":"PHASE2","title":"Efficacy of Dexmedetomidine As an Adjuvant to Bupivacaine in Pericapsular Nerve Group Block in Hip Replacement Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-03-01","conditions":"PENG Block","enrollment":60},{"nctId":"NCT06684015","phase":"","title":"The Effect of Intrathecal Morphine and Erector Spina Plan Block on Serum Cytokine Levels and Chronic Pain in Caesarean Section Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ankara University","startDate":"2024-03-01","conditions":"Cesarean Delivery, Postoperative Pain, Cytokine Levels","enrollment":110},{"nctId":"NCT06563349","phase":"PHASE4","title":"Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy","status":"RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2024-09-09","conditions":"Opioid Consumption, Multimodal Analgesia, Acute Appendicitis","enrollment":188},{"nctId":"NCT06685705","phase":"PHASE4","title":"Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl As Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-12-01","conditions":"Magnesium Sulfate, Neostigmine, Fentanyl","enrollment":66},{"nctId":"NCT03233633","phase":"PHASE1","title":"Marijuana in Combination With Opioids in Palliative and Hospice Patients","status":"COMPLETED","sponsor":"The Connecticut Hospice Inc.","startDate":"2017-05-10","conditions":"Pain","enrollment":66},{"nctId":"NCT06667024","phase":"NA","title":"Dexmedetomidine as an Intrathecal Adjuvant to Hyperbaric Bupivacaine for Postoperative Analgesia in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction Surgeries","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-09-01","conditions":"Dexmedetomidine, Intrathecal, Adjuvant","enrollment":64},{"nctId":"NCT06028061","phase":"NA","title":"Evaluation of Effectivity of Quadratus Lumborum Blocks With Adjuvant","status":"COMPLETED","sponsor":"Gaziosmanpasa Research and Education Hospital","startDate":"2023-09-01","conditions":"Postoperative Pain Management, Postoperative Pain, Analgesia","enrollment":83},{"nctId":"NCT04812028","phase":"PHASE2","title":"Magnesium Sulfate for Analgesia in Pediatric Transplant","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2021-03-01","conditions":"Postoperative Pain","enrollment":66},{"nctId":"NCT06658054","phase":"PHASE4","title":"Erector Spinae Plan Block (ESPB) with Dexmedetomidine and Dexamethasone in Lumbar Spine Fusion","status":"NOT_YET_RECRUITING","sponsor":"University of Southern California","startDate":"2024-11","conditions":"Lumbar Degenerative Disease","enrollment":46},{"nctId":"NCT06022614","phase":"NA","title":"Effect of Adding Dexmedetomidine As Adjuvant to Bupivacaine in US Guided ESPB for Post MRM Pain Management","status":"COMPLETED","sponsor":"Abanoub Habib","startDate":"2023-08-15","conditions":"Erector Spinae Plane Block","enrollment":60},{"nctId":"NCT06540534","phase":"NA","title":"Evaluation of Adjuvant Use in Selective Trunk Block","status":"COMPLETED","sponsor":"Gaziosmanpasa Research and Education Hospital","startDate":"2023-04-28","conditions":"Analgesia, Nerve Blocks, Postoperative Pain, Acute","enrollment":71},{"nctId":"NCT05855798","phase":"PHASE4","title":"Ketamine and Magnesium in Erector Spinae Plane Block","status":"COMPLETED","sponsor":"Cukurova University","startDate":"2023-05-10","conditions":"Postoperative Analgesia","enrollment":60},{"nctId":"NCT06577155","phase":"PHASE2","title":"Spinal Nalbuphine for Analgesia in Total Hip Arthroplasty","status":"RECRUITING","sponsor":"Asklepieion Voulas General Hospital","startDate":"2024-09-01","conditions":"Total Hip Arthroplasty, Analgesia","enrollment":60},{"nctId":"NCT06574451","phase":"NA","title":"Effectiveness and Safety of Adjuvant Software Based on Virtual Reality for Post-thoracoscopic Surgery Pain","status":"RECRUITING","sponsor":"Guangdong Provincial People's Hospital","startDate":"2023-04-22","conditions":"Acute Postoperative Pain, Video-assisted Thoracic Surgery, Virtual Reality","enrollment":215},{"nctId":"NCT03781505","phase":"PHASE4","title":"Intravenous Paracetamol in Combination With Caudal Ropivacaine","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2019-01-31","conditions":"Postoperative Analgesia","enrollment":64},{"nctId":"NCT06550414","phase":"NA","title":"Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor Analgesia","status":"COMPLETED","sponsor":"Services Institute of Medical Sciences, Pakistan","startDate":"2022-11-01","conditions":"Labor Analgesia, Labor Pain","enrollment":165},{"nctId":"NCT06522425","phase":"NA","title":"Usability Evaluation of a Mindfulness-based Serious Game","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2023-11-02","conditions":"Pain, Chronic","enrollment":19},{"nctId":"NCT06513013","phase":"PHASE2, PHASE3","title":"MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-07-20","conditions":"Cesarean Section","enrollment":68},{"nctId":"NCT06457581","phase":"NA","title":"Effectiveness of Dry Needling Adjuvant to Selective Serotonin Reputake Inhibitors vs TP Injection for Pain Management","status":"ACTIVE_NOT_RECRUITING","sponsor":"Superior University","startDate":"2023-11-01","conditions":"Pain, Fibromyalgia","enrollment":35},{"nctId":"NCT06131593","phase":"NA","title":"TAP Block With Methyl-prednisolone as a Pain Treatment Modality After Total Abdominal Hysterectomy Procedures","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2023-12-01","conditions":"Local Anesthetic, Ultrasound, Pain, Acute","enrollment":50},{"nctId":"NCT05552391","phase":"PHASE4","title":"Dexametomedine Versus Ketamine as an Adjuvant in Erector Spinae Block for Perioperative Thoracotomy Pain Control","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2022-09-01","conditions":"Post Operative Pain","enrollment":90},{"nctId":"NCT02932501","phase":"","title":"Medication-related Osteonecrosis of the Jaw (MRONJ) Registry","status":"ACTIVE_NOT_RECRUITING","sponsor":"AO Clinical Investigation and Publishing Documentation","startDate":"2017-08-14","conditions":"Medication-related Osteonecrosis of the Jaw, Bisphosphonate-Associated Osteonecrosis of the Jaw","enrollment":518},{"nctId":"NCT06306040","phase":"PHASE3","title":"Effect of Intravenous Nalbuphine and Magnesium Sulfate on Emergence Agitation in Pediatric","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-04-02","conditions":"Emergence Delirium","enrollment":105},{"nctId":"NCT06301789","phase":"NA","title":"Role of Magnesium Sulphate as an Adjuvant to Bupivacaine in U.S Guided Quadratus Lumborum Block in Lower Abdominal Cancer Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-04","conditions":"QLB in Lower Abdominal Cancer Surgeries as a Post Operative Analgesia","enrollment":52},{"nctId":"NCT05487001","phase":"NA","title":"Perineural Dexamethasone for Continuous Femoral Nerve Block","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2022-08-09","conditions":"Total Knee Arthroplasty","enrollment":18},{"nctId":"NCT05578885","phase":"NA","title":"Duration of Analgesia in Bier Block for Patients Undergoing Hand Surgery","status":"UNKNOWN","sponsor":"Michael Bishay Shehata Keroles","startDate":"2024-02-01","conditions":"Regional Anesthesia","enrollment":75},{"nctId":"NCT06180031","phase":"PHASE2, PHASE3","title":"Effect of Adding Magnesium Sulphate in Pericapsular Nerve Group Block","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2024-01-01","conditions":"Hip Fractures","enrollment":62},{"nctId":"NCT06166108","phase":"PHASE2, PHASE3","title":"Magnesium Sulphate Versus Dexamethasone as an Adjuvant to Bupivacaine in TAP Block for Abdominal Hysterectomy","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2023-12","conditions":"TAP Block","enrollment":56},{"nctId":"NCT05261672","phase":"NA","title":"Regional Midazolam in Quadratus Lumborum Block","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2022-03-15","conditions":"Postoperative Pain","enrollment":60},{"nctId":"NCT06118216","phase":"NA","title":"Costal Cartilage Donor-site Pain: Does Abdominal Muscle Infiltration Analgesia Work?","status":"COMPLETED","sponsor":"Xiaohui Su","startDate":"2022-12-01","conditions":"Rectus Abdominis and External Oblique Muscle Infiltration Analgesia","enrollment":60},{"nctId":"NCT05238506","phase":"PHASE4","title":"Lidocaine VS Hemodynamic, Metabolic and Hormonal Response","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2022-03-12","conditions":"Hemodynamic Response, Acute Appendicitis, Complication of Treatment","enrollment":132},{"nctId":"NCT06085417","phase":"NA","title":"Comparison of the Effects of Dexamethasone and magnesıum Sulphate Used as Adjuvant in Infraclavicular Nerve Block.","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2023-01-02","conditions":"Bupivacaine, Dexamethasone, Magnesıum Sulphate","enrollment":90},{"nctId":"NCT05845281","phase":"NA","title":"Comparison of Erector Spinae Plane Block and Intravenous Patient-controlled Analgesia in Percutaneous Nephrolithotomy","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2022-02-02","conditions":"Nephrolithiasis, Percutaneous, Analgesia","enrollment":90},{"nctId":"NCT05369468","phase":"PHASE1, PHASE2","title":"Dexmetomidine With Erector Spinae Plane Block in Cholecystectomy","status":"COMPLETED","sponsor":"Tanta University","startDate":"2020-01-22","conditions":"Dexmedtomidine in Erector Spinae Block for Laparscopic Cholecystectomy","enrollment":60},{"nctId":"NCT06046105","phase":"PHASE2, PHASE3","title":"Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2023-09-15","conditions":"Postoperative Pain, Acute","enrollment":180},{"nctId":"NCT05975957","phase":"NA","title":"Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis","status":"UNKNOWN","sponsor":"D'Or Institute for Research and Education","startDate":"2023-08-15","conditions":"Osteoarthritis, Gonarthrosis","enrollment":238},{"nctId":"NCT03770130","phase":"EARLY_PHASE1","title":"Dexmedetomidine and Liver Transplantation","status":"COMPLETED","sponsor":"RenJi Hospital","startDate":"2019-01-14","conditions":"Dexmedetomidine, Liver Transplantation, Allograft Function, Survival","enrollment":330},{"nctId":"NCT05342844","phase":"NA","title":"Different Doses of Dexmedetomidine Added to Bupivacaine in Transversus Abdominis Plane Block in Caesarean Delivery","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2022-05-01","conditions":"Analgesia","enrollment":81},{"nctId":"NCT05871073","phase":"PHASE4","title":"Dexamethasone as Adjuvant to Ropivacaine in Wound Infiltration for Postoperative Analgesia Following Spinal Surgery","status":"COMPLETED","sponsor":"University Hospital Fattouma Bourguiba","startDate":"2023-01-01","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis","enrollment":60},{"nctId":"NCT05843812","phase":"","title":"Magnesium Sulfate in Bariatric Surgery","status":"UNKNOWN","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2023-04-21","conditions":"Anesthesia and Analgesia, Magnesium Sulfate, Bariatric Surgery Candidate","enrollment":104},{"nctId":"NCT05635877","phase":"PHASE4","title":"Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients","status":"RECRUITING","sponsor":"Yongtao Sun","startDate":"2023-02-07","conditions":"Frailty, Esmolol, Myocardial Injury","enrollment":2000},{"nctId":"NCT04160520","phase":"PHASE1, PHASE2","title":"Pramipexole and Morphine for Renal Colic","status":"COMPLETED","sponsor":"East Carolina University","startDate":"2019-10-28","conditions":"Renal Colic","enrollment":19},{"nctId":"NCT05694897","phase":"NA","title":"Erector Spinae Block Using a Dexmedetomidine Versus Magnesium Sulfate as an Adjuvant to Bupivacaine","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-07-30","conditions":"Postoperative Analgesia","enrollment":52},{"nctId":"NCT05617976","phase":"NA","title":"Nalbuphine as an Adjuvant to Levobupivacaine in Caudal Analgesia in Children","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2020-10-04","conditions":"Caudal Anesthesia","enrollment":64},{"nctId":"NCT05237089","phase":"NA","title":"Effect of Electroacupuncture on Obesity","status":"RECRUITING","sponsor":"Shanghai Municipal Hospital of Traditional Chinese Medicine","startDate":"2022-09-01","conditions":"Obesity","enrollment":256},{"nctId":"NCT05577260","phase":"NA","title":"The Effect of Intraperitoneal Injection of Magnesium Sulphate Versus Dexmedetomidine as an Adjuvant to Bupivacaine on Postoperative Analgesia in Patients Undergoing Abdominal Aortic Surgery","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2022-10-01","conditions":"Abdominal Aortic Surgery","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":34,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Adjuvant analgesia","genericName":"Adjuvant analgesia","companyName":"University of Southern California","companyId":"university-of-southern-california","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Adjuvant analgesics are medications that enhance pain relief when used alongside primary analgesics, working through various mechanisms including modulation of neurotransmitters and pain pathways. Used for Chronic pain when used adjunctively with primary analgesics, Neuropathic pain, Cancer pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}