{"id":"adipic-acid","rwe":[{"pmid":"41887515","year":"2026","title":"Comparative analysis of fecal microbiome, metabolome, and serum metabolome in cows with different milk urea nitrogen phenotypes.","finding":"","journal":"Journal of dairy science","studyType":"Clinical Study"},{"pmid":"41872847","year":"2026","title":"Biosensor-guided directed evolution of aldehyde dehydrogenase for improved adipic acid production from caprolactone.","finding":"","journal":"Journal of biological engineering","studyType":"Clinical Study"},{"pmid":"41850025","year":"2026","title":"Unlocking NO resistance in low-temperature N(2)O decomposition: The critical role of zeolite with rare earth-modified Co(3)O(4).","finding":"","journal":"Journal of colloid and interface science","studyType":"Clinical Study"},{"pmid":"41828772","year":"2026","title":"Eugenol-Based Epoxy Vitrimers: Caffeine and Zinc Acetate as Potential Alternative Catalysts in Curing Kinetics and Dynamic Network Properties.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41817354","year":"2026","title":"Cross-Species Reprogramming of Developmental Plasticity and Metabolic Rewiring via Banana-Derived WUS2 Developmental Regulator.","finding":"","journal":"Plant biotechnology journal","studyType":"Clinical Study"}],"tags":[{"label":"adipic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"adipinic acid","offLabel":[],"synonyms":["adipinic acid","1,4-Butanedicarboxylic acid","hexanedioic acid","adipic acid"],"timeline":[],"brandName":"Adipinic Acid","ecosystem":[],"mechanism":{"target":"Solute carrier family 22 member 6","modality":"Small Molecule","drugClass":"adipic acid","explanation":"Imagine your body is like a factory that builds things. Adipic acid is a raw material that gets converted into a long chain of molecules, kind of like a big Lego structure. This chain is then used to make synthetic materials like nylon, which is used in clothing and other products.","oneSentence":"Adipic acid works by being converted into a polymer, which is then used to create synthetic materials.","technicalDetail":"Adipic acid is a dicarboxylic acid that undergoes condensation polymerization to form a polyamide, which is then used as a precursor in the production of nylon and other polyamides."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Adipic_acid","title":"Adipic acid","extract":"Adipic acid or hexanedioic acid is an organic compound with the chemical formula C6H10O4. It is a white crystalline powder at standard temperature and pressure. From an industrial perspective, it is the most important dicarboxylic acid at about 2.5 billion kilograms produced annually, mainly as a precursor for the production of nylon. Adipic acid otherwise rarely occurs in nature, but it is known as manufactured E number food additive E355. Salts and esters of adipic acid are known as adipates."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3474","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=adipic%20acid","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=adipic acid","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Adipic_acid","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:28:57.596783","biosimilars":[],"competitors":[{"drugName":"aminohippuric acid","drugSlug":"aminohippuric-acid","fdaApproval":"1944-12-30","relationship":"same-target"},{"drugName":"dinoprostone","drugSlug":"dinoprostone","fdaApproval":"1977-08-23","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"fluorescein","drugSlug":"fluorescein","fdaApproval":"2020-03-09","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"ibuprofen","drugSlug":"ibuprofen","fdaApproval":"1974-09-19","patentExpiry":"Sep 30, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"probenecid","drugSlug":"probenecid","fdaApproval":"1951-04-26","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"adipic acid","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"aminohippuric-acid","brandName":"aminohippuric acid","genericName":"aminohippuric acid","approvalYear":"1944","relationship":"same-target"},{"drugId":"dinoprostone","brandName":"dinoprostone","genericName":"dinoprostone","approvalYear":"1977","relationship":"same-target"},{"drugId":"fluorescein","brandName":"fluorescein","genericName":"fluorescein","approvalYear":"2020","relationship":"same-target"},{"drugId":"ibuprofen","brandName":"ibuprofen","genericName":"ibuprofen","approvalYear":"1974","relationship":"same-target"},{"drugId":"probenecid","brandName":"probenecid","genericName":"probenecid","approvalYear":"1951","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT04239989","phase":"PHASE1","title":"Itacitinib for the Treatment of Bronchiolitis Obliterans Syndrome After Donor Hematopoietic Cell Transplant","status":"TERMINATED","sponsor":"M.D. Anderson Cancer Center","startDate":"2021-10-08","conditions":["Bronchiolitis Obliterans"],"enrollment":8,"completionDate":"2025-10-31"},{"nctId":"NCT06285799","phase":"PHASE3","title":"Safety and Effectiveness of Iron Hydroxide Adipate Tartrate (IHAT) in Iron Deficient Premenopausal Women","status":"COMPLETED","sponsor":"Nemysis Ltd","startDate":"2024-03-05","conditions":["Iron-deficiency"],"enrollment":180,"completionDate":"2025-02-15"},{"nctId":"NCT03212677","phase":"NA","title":"Safe and Effective Delivery of Supplemental Iron to Healthy Volunteers","status":"COMPLETED","sponsor":"Tufts University","startDate":"2017-05-17","conditions":["Iron"],"enrollment":226,"completionDate":"2022-07-30"},{"nctId":"NCT04339101","phase":"PHASE2","title":"Itacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplastic Syndrome, or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation","status":"ACTIVE_NOT_RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2020-11-11","conditions":["Acute Leukemia","Hematologic and Lymphocytic Disorder","Myelodysplastic Syndrome","Primary Myelofibrosis","Secondary Myelofibrosis"],"enrollment":59,"completionDate":"2026-01-20"},{"nctId":"NCT04200365","phase":"PHASE2","title":"A Study of Itacitinib for the Treatment of Chronic Graft Versus Host Disease (cGVHD)","status":"TERMINATED","sponsor":"SCRI Development Innovations, LLC","startDate":"2020-06-05","conditions":["Chronic Graft-versus-host-disease"],"enrollment":15,"completionDate":"2023-09-07"},{"nctId":"NCT04305249","phase":"PHASE1","title":"Safety and Preliminary Efficacy of ATG-017 Monotherapy or Combination Therapy With Nivolumab in Advanced Solid Tumors and Hematological Malignancies","status":"TERMINATED","sponsor":"Antengene Therapeutics Limited","startDate":"2020-08-15","conditions":["Solid Tumor","Hematological Malignancy"],"enrollment":36,"completionDate":"2024-05-24"},{"nctId":"NCT04070781","phase":"PHASE1","title":"Itacitinib and Tocilizumab for Steroid Refractory Acute Graft Versus Host Disease","status":"TERMINATED","sponsor":"Columbia University","startDate":"2020-01-20","conditions":["Steroid Refractory GVHD","Graft Vs Host Disease"],"enrollment":1,"completionDate":"2021-12-13"},{"nctId":"NCT05414747","phase":"NA","title":"Clinical Investigation of the Safety and Effectiveness of the ABV-1701 Ocular Endotamponade (OE)","status":"SUSPENDED","sponsor":"BioFirst Corporation","startDate":"2023-04-15","conditions":["Retinal Detachment"],"enrollment":40,"completionDate":"2025-12-15"},{"nctId":"NCT05589051","phase":"NA","title":"Effect of Alpha Hope Dietary Supplement on Health and Cognitive Performance","status":"COMPLETED","sponsor":"University of Memphis","startDate":"2022-03-21","conditions":["Cognitive Change"],"enrollment":14,"completionDate":"2022-11-10"},{"nctId":"NCT04716985","phase":"NA","title":"Evaluation of the Daily Intake of 0.5 L of Water Saturated With Molecular Hydrogen for 21 Days in COVID-19 Patients Treated in Ambulatory Care","status":"UNKNOWN","sponsor":"AGIR à Dom","startDate":"2021-01-22","conditions":["SARS-CoV-2","Covid19","AMBULATORY CARE"],"enrollment":700,"completionDate":"2023-05-22"},{"nctId":"NCT02941081","phase":"PHASE2","title":"A Novel Nano-iron Supplement to Safely Combat Iron Deficiency and Anaemia in Young Children: a Doubleblind Randomised Controlled Trial","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2018-01-08","conditions":["Iron Deficiency, Anaemia in Children"],"enrollment":645,"completionDate":"2019-05-28"},{"nctId":"NCT02151643","phase":"PHASE2","title":"Study to Evaluate the Efficacy and Safety of PT20 in Subjects With Hyperphosphataemia and Dialysis Dependent Chronic Kidney Disease","status":"COMPLETED","sponsor":"Phosphate Therapeutics","startDate":"2014-05-07","conditions":["Hyperphosphataemia"],"enrollment":153,"completionDate":"2015-03-18"},{"nctId":"NCT02498886","phase":"EARLY_PHASE1","title":"IHAT Absorption Kinetics","status":"COMPLETED","sponsor":"Medical Research Council","startDate":"2015-08","conditions":["Iron-deficiency Anemia"],"enrollment":34,"completionDate":"2016-03"},{"nctId":"NCT01991574","phase":"EARLY_PHASE1","title":"Effect of the Consumption of Ferric Hydroxide Adipate on Urinary Phosphorus Excretion.","status":"COMPLETED","sponsor":"Medical Research Council","startDate":"2009-04","conditions":["Healthy","Chronic Kidney Diseases"],"enrollment":30,"completionDate":"2009-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"MMSL":"NOCODE","NDDF":"004919","UNII":"76A0JE0FKJ","CHEBI":"CHEBI:30832","RXNORM":"17050","UMLSCUI":"C0050846","ChEMBL_ID":"CHEMBL1157","KEGG_DRUG":"D08839","DRUGBANK_ID":"DB16084","PDB_CHEM_ID":" 0L1","PUBCHEM_CID":"196","MESH_SUPPLEMENTAL_RECORD_UI":"C029900"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1246,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 24","pmid":"41887515","title":"Comparative analysis of fecal microbiome, metabolome, and serum metabolome in cows with different milk urea nitrogen phenotypes.","journal":"Journal of dairy science"},{"date":"2026 Mar 23","pmid":"41872847","title":"Biosensor-guided directed evolution of aldehyde dehydrogenase for improved adipic acid production from caprolactone.","journal":"Journal of biological engineering"},{"date":"2026 Mar 16","pmid":"41850025","title":"Unlocking NO resistance in low-temperature N(2)O decomposition: The critical role of zeolite with rare earth-modified Co(3)O(4).","journal":"Journal of colloid and interface science"},{"date":"2026 Feb 26","pmid":"41828772","title":"Eugenol-Based Epoxy Vitrimers: Caffeine and Zinc Acetate as Potential Alternative Catalysts in Curing Kinetics and Dynamic Network Properties.","journal":"Molecules (Basel, Switzerland)"},{"date":"2026 Mar 12","pmid":"41817354","title":"Cross-Species Reprogramming of Developmental Plasticity and Metabolic Rewiring via Banana-Derived WUS2 Developmental Regulator.","journal":"Plant biotechnology journal"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Adipic acid is a small molecule drug of the adipic acid class, but it is not a pharmaceutical drug. It is a dicarboxylic acid used as a precursor in the production of nylon and other polyamides. The original developer and current owner of adipic acid are not specified in the provided facts. Adipic acid is not FDA-approved for any indications and its commercial status, safety considerations, and pharmacokinetic properties are unknown. As a result, there is no information available on its use as a pharmaceutical agent.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}