{"id":"adiphenine","rwe":[{"pmid":"40772705","year":"2025","title":"Adiphenine Alleviates Impulsive-Like Behaviors in Aged Mice by Inhibiting Nicotinic Acetylcholine Receptors.","finding":"","journal":"Journal of neurochemistry","studyType":"Clinical Study"},{"pmid":"39238418","year":"2024","title":"Chemoselective deoxygenative α-arylation of carboxylic acids, amides, and esters: synthesis of anesthetic and anti-inflammatory compounds.","finding":"","journal":"Chemical communications (Cambridge, England)","studyType":"Clinical Study"},{"pmid":"38247255","year":"2025","title":"Novel integrated Omics based computational approach for drug repurposing for non-muscle invasive bladder cancer (NMIBC).","finding":"","journal":"Journal of biomolecular structure & dynamics","studyType":"Clinical Study"},{"pmid":"36181673","year":"2022","title":"Highly Site-Selective Direct C-H Bond Functionalization of Unactivated Arenes with Propargyl α-Aryl-α-diazoacetates via Scandium Catalysis.","finding":"","journal":"The Journal of organic chemistry","studyType":"Clinical Study"},{"pmid":"34295919","year":"2021","title":"Identification and Exploration of Novel Macrophage M2-Related Biomarkers and Potential Therapeutic Agents in Endometriosis.","finding":"","journal":"Frontiers in molecular biosciences","studyType":"Clinical Study"}],"tags":[{"label":"adiphenine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"diphacil","offLabel":[],"synonyms":["adiphenine","adiphenin","diphacil","diphenylacetic acid diethylaminoethyl ester","tranzetil","trasentin","trasentine","adiphenine hydrochloride","adiphenine HCl"],"timeline":[],"aiSummary":"Diphacil, also known as Adiphenine, is a small molecule drug in the adiphenine class. Its exact target and mechanism of action are unknown, but it is believed to work by modulating certain physiological processes. Diphacil's commercial status and approved indications are unclear, and it is not known whether it is patented or available as a generic medication. Further research is needed to fully understand its properties and potential uses. As a result, key safety considerations and pharmacokinetic parameters, such as half-life and bioavailability, are also unknown.","brandName":"Diphacil","ecosystem":[],"mechanism":{"target":"Histamine H1 receptor, Muscarinic acetylcholine receptor","modality":"Small Molecule","drugClass":"adiphenine","explanation":"Think of Diphacil like a key that unlocks a specific process in the body. When it binds to its target, it can either turn the process up or down, depending on what's needed. This can help restore balance to the body's systems and alleviate symptoms of certain conditions.","oneSentence":"Diphacil is believed to work by modulating certain physiological processes.","technicalDetail":"The exact mechanism of action of Diphacil is unknown, but it is thought to involve interaction with a specific receptor or enzyme that plays a role in regulating various physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/94","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ADIPHENINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:28:49.313689","biosimilars":[],"competitors":[{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"azatadine","drugSlug":"azatadine","fdaApproval":"1977-03-29","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"chlorphenamine","drugSlug":"chlorphenamine","fdaApproval":"1950-08-15","relationship":"same-target"},{"drugName":"chlorprothixene","drugSlug":"chlorprothixene","fdaApproval":"1967-06-19","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"clomipramine","drugSlug":"clomipramine","fdaApproval":"1989-12-29","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"clozapine","drugSlug":"clozapine","fdaApproval":"1989-09-26","patentExpiry":"May 1, 2028","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"desipramine","drugSlug":"desipramine","fdaApproval":"1964-11-20","genericCount":8,"patentStatus":"Off-patent — generic 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available","relationship":"same-target"},{"drugName":"histamine","drugSlug":"histamine","fdaApproval":"1939-04-25","patentStatus":"Unknown","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"adiphenine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"amitriptyline","brandName":"amitriptyline","genericName":"amitriptyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"azatadine","brandName":"azatadine","genericName":"azatadine","approvalYear":"1977","relationship":"same-target"},{"drugId":"chlorphenamine","brandName":"chlorphenamine","genericName":"chlorphenamine","approvalYear":"1950","relationship":"same-target"},{"drugId":"chlorprothixene","brandName":"chlorprothixene","genericName":"chlorprothixene","approvalYear":"1967","relationship":"same-target"},{"drugId":"clomipramine","brandName":"clomipramine","genericName":"clomipramine","approvalYear":"1989","relationship":"same-target"},{"drugId":"clozapine","brandName":"clozapine","genericName":"clozapine","approvalYear":"1989","relationship":"same-target"},{"drugId":"desipramine","brandName":"desipramine","genericName":"desipramine","approvalYear":"1964","relationship":"same-target"},{"drugId":"fentanyl","brandName":"fentanyl","genericName":"fentanyl","approvalYear":"1968","relationship":"same-target"},{"drugId":"haloperidol","brandName":"haloperidol","genericName":"haloperidol","approvalYear":"1967","relationship":"same-target"},{"drugId":"histamine","brandName":"histamine","genericName":"histamine","approvalYear":"1939","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"001756","UNII":"YKG6OR043Q","CHEBI":"CHEBI:94680","INN_ID":"2715","RXNORM":"235433","UMLSCUI":"C0001521","ChEMBL_ID":"CHEMBL353846","KEGG_DRUG":"D02772","DRUGBANK_ID":"DB15795","PUBCHEM_CID":"2031","SNOMEDCT_US":"21394008","SECONDARY_CAS_RN":"50-42-0","MESH_SUPPLEMENTAL_RECORD_UI":"C084829"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":70,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Aug","pmid":"40772705","title":"Adiphenine Alleviates Impulsive-Like Behaviors in Aged Mice by Inhibiting Nicotinic Acetylcholine Receptors.","journal":"Journal of neurochemistry"},{"date":"2024 Sep 24","pmid":"39238418","title":"Chemoselective deoxygenative α-arylation of carboxylic acids, amides, and esters: synthesis of anesthetic and anti-inflammatory compounds.","journal":"Chemical communications (Cambridge, England)"},{"date":"2025 Mar","pmid":"38247255","title":"Novel integrated Omics based computational approach for drug repurposing for non-muscle invasive bladder cancer (NMIBC).","journal":"Journal of biomolecular structure & dynamics"},{"date":"2022 Nov 4","pmid":"36181673","title":"Highly Site-Selective Direct C-H Bond Functionalization of Unactivated Arenes with Propargyl α-Aryl-α-diazoacetates via Scandium Catalysis.","journal":"The Journal of organic chemistry"},{"date":"2021","pmid":"34295919","title":"Identification and Exploration of Novel Macrophage M2-Related 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