{"id":"adinazolam","rwe":[],"tags":[{"label":"adinazolam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Translocator protein","category":"target"},{"label":"TSPO","category":"gene"},{"label":"GABRA1","category":"gene"},{"label":"GABRA2","category":"gene"},{"label":"N05BA07","category":"atc"},{"label":"Active","category":"status"},{"label":"Anxiety","category":"indication"},{"label":"Antidepressive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"deracyn","offLabel":[],"synonyms":["adinazolam","adinazolam mesylate","adinazolam mesilate","deracyn"],"timeline":[],"brandName":"Deracyn","ecosystem":[{"indication":"Anxiety","otherDrugs":[{"name":"alprazolam","slug":"alprazolam","company":"Pharmacia And Upjohn"},{"name":"chlordiazepoxide","slug":"chlordiazepoxide","company":"Valeant Pharm Intl"},{"name":"chlormezanone","slug":"chlormezanone","company":""},{"name":"clorazepate","slug":"clorazepate","company":"Recordati Rare"}],"globalPrevalence":301000000}],"mechanism":{"target":"Translocator protein","targets":[{"gene":"TSPO","source":"DrugCentral","target":"Translocator protein","protein":"Translocator protein"},{"gene":"GABRA1","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit alpha-1"},{"gene":"GABRA2","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit alpha-2"},{"gene":"GABRA3","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit alpha-3"},{"gene":"GABRA4","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit alpha-4"},{"gene":"GABRA5","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit alpha-5"},{"gene":"GABRA6","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit alpha-6"},{"gene":"GABRB1","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit beta-1"},{"gene":"GABRB2","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit beta-2"},{"gene":"GABRB3","source":"DrugCentral","target":"GABA-A receptor","protein":"Gamma-aminobutyric acid receptor subunit beta-3"}],"modality":"Small Molecule","drugClass":"adinazolam","explanation":"Think of it like a key fitting into a lock. Deracyn binds to the translocator protein, which helps to increase the activity of GABA, a chemical messenger that helps to calm the brain and reduce anxiety. This can lead to a sense of relaxation and reduced worry.","oneSentence":"Deracyn works by binding to the translocator protein, which is involved in regulating the activity of GABA, a neurotransmitter that helps calm the brain.","technicalDetail":"Deracyn acts as a positive allosteric modulator of the translocator protein, which is a receptor that regulates the activity of GABA and other neurotransmitters. By binding to this receptor, Deracyn increases the activity of GABA, leading to a decrease in anxiety and other symptoms."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Adinazolam","title":"Adinazolam","extract":"Adinazolam is a tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring. It possesses anxiolytic, anticonvulsant, sedative, and antidepressant properties. Adinazolam was developed by Jackson B. Hester, who was seeking to enhance the antidepressant properties of alprazolam, which he also developed. Adinazolam was never FDA approved and never made available to the public market; however, it has been sold as a designer drug."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/93","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ADINAZOLAM","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Adinazolam","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:28:43.792837","biosimilars":[],"competitors":[{"drugName":"diazepam","drugSlug":"diazepam","fdaApproval":"1963-11-15","patentExpiry":"Oct 16, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlordiazepoxide","drugSlug":"chlordiazepoxide","fdaApproval":"1960-02-24","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxazepam","drugSlug":"oxazepam","fdaApproval":"1965-06-04","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clorazepate","drugSlug":"clorazepate","fdaApproval":"1972-06-23","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lorazepam","drugSlug":"lorazepam","fdaApproval":"1977-09-30","patentExpiry":"Jan 8, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clobazam","drugSlug":"clobazam","fdaApproval":"2011-10-21","patentExpiry":"Sep 5, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prazepam","drugSlug":"prazepam","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alprazolam","drugSlug":"alprazolam","fdaApproval":"1981-10-16","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"halazepam","drugSlug":"halazepam","fdaApproval":"1981-09-24","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"adinazolam","indications":{"approved":[{"name":"Anxiety","source":"DrugCentral","snomedId":48694002,"regulator":"FDA","usPrevalence":40000000,"globalPrevalence":301000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2022"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diazepam","brandName":"diazepam","genericName":"diazepam","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlordiazepoxide","brandName":"chlordiazepoxide","genericName":"chlordiazepoxide","approvalYear":"1960","relationship":"same-class"},{"drugId":"oxazepam","brandName":"oxazepam","genericName":"oxazepam","approvalYear":"1965","relationship":"same-class"},{"drugId":"clorazepate","brandName":"clorazepate","genericName":"clorazepate","approvalYear":"1972","relationship":"same-class"},{"drugId":"lorazepam","brandName":"lorazepam","genericName":"lorazepam","approvalYear":"1977","relationship":"same-class"},{"drugId":"clobazam","brandName":"clobazam","genericName":"clobazam","approvalYear":"2011","relationship":"same-class"},{"drugId":"prazepam","brandName":"prazepam","genericName":"prazepam","approvalYear":"","relationship":"same-class"},{"drugId":"alprazolam","brandName":"alprazolam","genericName":"alprazolam","approvalYear":"1981","relationship":"same-class"},{"drugId":"halazepam","brandName":"halazepam","genericName":"halazepam","approvalYear":"1981","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"KN08449444","CHEBI":"CHEBI:251412","INN_ID":"4996","UMLSCUI":"C0050844","ChEMBL_ID":"CHEMBL328250","KEGG_DRUG":"D02770","DRUGBANK_ID":"DB00546","PUBCHEM_CID":"37632","SECONDARY_CAS_RN":"57938-82-6","MESH_SUPPLEMENTAL_RECORD_UI":"C039668"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"2.1 hours","clearance":"6.2 mL/min/kg","bioavailability":"39%","fractionUnbound":"0.31%","volumeOfDistribution":"0.98 L/kg"},"publicationCount":108,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05BA07","allCodes":["N05BA07"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Deracyn is a small molecule modality. It is also known by the synonyms ADINAZOLAM MESILATE, ADINAZOLAM MESYLATE, ADINAZOLAM MESYLATE, ADINAZOLAM METHANESULFONATE, ADINAZOLAM METHANESULFONATE, and U-41,123F.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}