{"id":"ademetionine-3","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ademetionine (also known as S-adenosyl methionine or SAM) is an endogenous compound that serves as the primary methyl donor in the body. It participates in critical methylation reactions involved in neurotransmitter synthesis, phospholipid metabolism, and antioxidant defense. By restoring depleted SAM levels, it supports hepatocyte regeneration and improves liver function in conditions characterized by SAM deficiency.","oneSentence":"Ademetionine is a methyl donor that replenishes cellular S-adenosylmethionine (SAM) levels to support methylation reactions and hepatic function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:19:03.045Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Liver disease and hepatic dysfunction"},{"name":"Cholestasis"},{"name":"Hepatic cirrhosis"}]},"trialDetails":[{"nctId":"NCT06922669","phase":"NA","title":"Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia","status":"RECRUITING","sponsor":"General Hospital of Shenyang Military Region","startDate":"2025-06-24","conditions":"Drug Induced Liver Injury","enrollment":232},{"nctId":"NCT07070856","phase":"NA","title":"Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study)","status":"COMPLETED","sponsor":"Children's Hospital and Institute of Child Health, Multan","startDate":"2024-12-31","conditions":"Severe Acute Malnutrition, Persistent Diarrhea, Children","enrollment":320},{"nctId":"NCT07068191","phase":"NA","title":"Gepaktiv vs UDCA and Ademetionine in MAFLD With Hepatomegaly","status":"RECRUITING","sponsor":"Phenomen Pharma","startDate":"2025-06-19","conditions":"Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD), Hepatomegaly, Nonalcoholic Fatty Liver (NAFL)","enrollment":90},{"nctId":"NCT03535675","phase":"PHASE3","title":"Muscadine Plus (MPX) In Men With Prostate Cancer","status":"TERMINATED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins","startDate":"2018-10-30","conditions":"Adenocarcinoma of the Prostate","enrollment":59},{"nctId":"NCT04313348","phase":"NA","title":"Patient-centered Mobile Technology Interventions to Improve Maternal Health in Uganda","status":"COMPLETED","sponsor":"Mbarara University of Science and Technology","startDate":"2020-08-01","conditions":"Maternal Child Health","enrollment":170},{"nctId":"NCT03721679","phase":"PHASE1, PHASE2","title":"Poly-ICLC (Hiltonol) and Anti-PD1 or Anti-PD-L1","status":"TERMINATED","sponsor":"Oncovir, Inc.","startDate":"2018-09-25","conditions":"Solid Cancer","enrollment":7},{"nctId":"NCT03319173","phase":"NA","title":"Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation","status":"COMPLETED","sponsor":"Bristlecone Health, Inc.","startDate":"2017-10-15","conditions":"Mild Cognitive Impairment, Metabolic Syndrome","enrollment":98},{"nctId":"NCT02264860","phase":"NA","title":"Researching Alveolar Macrophage Improvements With Supplements in HIV","status":"COMPLETED","sponsor":"Emory University","startDate":"2014-10","conditions":"HIV-1 Infection","enrollment":67},{"nctId":"NCT03863002","phase":"PHASE1, PHASE2","title":"Safety and Efficacy of Mesenchymal Stem Cell Transplantation for Acute-on-Chronic Liver Failure","status":"UNKNOWN","sponsor":"Tianjin Weikai Bioeng., Ltd.","startDate":"2019-10-01","conditions":"Liver Failure, Acute on Chronic","enrollment":45},{"nctId":"NCT00762268","phase":"NA","title":"A Trial of SAMe for Treatment-Resistant Bipolar Depression","status":"COMPLETED","sponsor":"Mclean Hospital","startDate":"2008-09","conditions":"Bipolar Disorder, Depression, Bipolar Depression","enrollment":23},{"nctId":"NCT00573313","phase":"PHASE3","title":"Effects of SAMe in Patients With Alcoholic Liver Disease","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2005-09","conditions":"Liver Disease, Alcoholic","enrollment":94},{"nctId":"NCT00101452","phase":"NA","title":"Safety and Effectiveness of S-adenosyl-l-methionine (SAMe) for the Treatment of Major Depression","status":"COMPLETED","sponsor":"Maurizio Fava, MD","startDate":"2005-04","conditions":"Depression","enrollment":199},{"nctId":"NCT01998620","phase":"PHASE4","title":"Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis","status":"UNKNOWN","sponsor":"Zhejiang Hisun Pharmaceutical Co. 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