{"id":"ademetionine","rwe":[],"tags":[{"label":"ademetionine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Phenylethanolamine N-methyltransferase","category":"target"},{"label":"PNMT","category":"gene"},{"label":"PRMT1","category":"gene"},{"label":"PCMT1","category":"gene"},{"label":"A16AA02","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_3","safety":{"safetySignals":[{"llr":127.288,"date":"","count":18,"signal":"Confabulation","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=127)"},{"llr":76.786,"date":"","count":26,"signal":"Serotonin syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 26 times (LLR=77)"},{"llr":72.71,"date":"","count":18,"signal":"Nystagmus","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=73)"},{"llr":60.229,"date":"","count":9,"signal":"Right aortic arch","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=60)"},{"llr":56.533,"date":"","count":9,"signal":"Congenital arterial malformation","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=57)"},{"llr":53.254,"date":"","count":25,"signal":"Rhabdomyolysis","source":"DrugCentral FAERS","actionTaken":"Reported 25 times (LLR=53)"},{"llr":50.028,"date":"","count":40,"signal":"Drug interaction","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=50)"},{"llr":44.829,"date":"","count":18,"signal":"Dyskinesia","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=45)"},{"llr":41.247,"date":"","count":7,"signal":"Mechanical urticaria","source":"DrugCentral FAERS","actionTaken":"Reported 7 times (LLR=41)"},{"llr":34.69,"date":"","count":19,"signal":"Foetal exposure during pregnancy","source":"DrugCentral FAERS","actionTaken":"Reported 19 times (LLR=35)"},{"llr":34.14,"date":"","count":14,"signal":"Myelosuppression","source":"DrugCentral FAERS","actionTaken":"Reported 14 times (LLR=34)"},{"llr":33.708,"date":"","count":9,"signal":"Clonus","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=34)"}],"commonSideEffects":[{"effect":"Confabulation","drugRate":"LLR 127","severity":"common"},{"effect":"Serotonin syndrome","drugRate":"LLR 77","severity":"common"},{"effect":"Nystagmus","drugRate":"LLR 73","severity":"common"},{"effect":"Right aortic arch","drugRate":"LLR 60","severity":"common"},{"effect":"Congenital arterial malformation","drugRate":"LLR 57","severity":"common"},{"effect":"Rhabdomyolysis","drugRate":"LLR 53","severity":"common"},{"effect":"Drug interaction","drugRate":"LLR 50","severity":"common"},{"effect":"Dyskinesia","drugRate":"LLR 45","severity":"common"},{"effect":"Mechanical urticaria","drugRate":"LLR 41","severity":"common"},{"effect":"Foetal exposure during pregnancy","drugRate":"LLR 35","severity":"common"},{"effect":"Myelosuppression","drugRate":"LLR 34","severity":"common"},{"effect":"Clonus","drugRate":"LLR 34","severity":"common"}],"contraindications":["Diabetes mellitus","Hyperlipidemia","Hypertensive disorder"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"donamet","offLabel":[],"synonyms":["ademetionin","methioninyl adenylate","s-adenosylmethionine","ademetionine","donamet"],"timeline":[],"aiSummary":"Donamet is a small molecule with the synonyms adenosylmethionine (ADEMETIONINA, ADEMETIONINE, etc.).","brandName":"Donamet","ecosystem":[],"mechanism":{"target":"Protein-beta-aspartate methyltransferase, Phenylethanolamine N-methyltransferase, Protein arginine N-methyltransferase 1","targets":[{"gene":"PNMT","source":"DrugCentral","target":"Phenylethanolamine N-methyltransferase","protein":"Phenylethanolamine N-methyltransferase"},{"gene":"PRMT1","source":"DrugCentral","target":"Protein arginine N-methyltransferase 1","protein":"Protein arginine N-methyltransferase 1"},{"gene":"PCMT1","source":"DrugCentral","target":"Protein-beta-aspartate methyltransferase","protein":"Protein-L-isoaspartate(D-aspartate) O-methyltransferase"}],"modality":"Small Molecule","drugClass":"ademetionine","explanation":"Think of it like a traffic cop: Donamet helps regulate the flow of certain chemicals in the brain by blocking the enzyme that breaks them down. This can help maintain a healthy balance of these chemicals, which is essential for various bodily functions.","oneSentence":"Donamet works by inhibiting the enzyme Phenylethanolamine N-methyltransferase, which plays a role in the breakdown of certain neurotransmitters.","technicalDetail":"Donamet specifically inhibits the activity of Phenylethanolamine N-methyltransferase, a key enzyme involved in the catecholamine biosynthesis pathway, thereby modulating the levels of neurotransmitters such as epinephrine and norepinephrine."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2414","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ADEMETIONINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ADEMETIONINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:27:50.507224","biosimilars":[],"competitors":[{"drugName":"levocarnitine","drugSlug":"levocarnitine","fdaApproval":"1985-12-27","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"glutamine","drugSlug":"glutamine","fdaApproval":"2004-06-10","relationship":"same-class"},{"drugName":"mercaptamine","drugSlug":"mercaptamine","fdaApproval":"1994-08-15","relationship":"same-class"},{"drugName":"carglumic 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