{"id":"adefor-dipivoxil","safety":{"commonSideEffects":[{"rate":null,"effect":"Nephrotoxicity / renal dysfunction"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Asthenia"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adefovir dipivoxil is a prodrug that is converted to adefovir in vivo, which then acts as a nucleotide analog inhibitor of hepatitis B virus (HBV) reverse transcriptase. It prevents viral DNA synthesis and replication, thereby reducing HBV viral load and improving liver function in chronic hepatitis B patients.","oneSentence":"Adeforvir dipivoxil is a nucleotide reverse transcriptase inhibitor that blocks viral replication in hepatitis B by inhibiting the reverse transcriptase enzyme.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:18.968Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic hepatitis B infection"}]},"trialDetails":[{"nctId":"NCT01205165","phase":"PHASE4","title":"An Open Label, Multi Centre Phase IV Study of Adefovir Dipivoxil in Korean Patients With Chronic Hepatitis B (CHB)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2004-12-17","conditions":"Hepatitis B, Chronic","enrollment":104}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1019,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Adefor dipivoxil","genericName":"Adefor dipivoxil","companyName":"GlaxoSmithKline","companyId":"glaxosmithkline","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Adeforvir dipivoxil is a nucleotide reverse transcriptase inhibitor that blocks viral replication in hepatitis B by inhibiting the reverse transcriptase enzyme. Used for Chronic hepatitis B infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}