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The 'additional PVB' designation suggests this is a study of ropivacaine administered via paravertebral block, a regional anesthesia technique.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:59:44.220Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia via paravertebral block (Phase 3 investigational use)"}]},"trialDetails":[{"nctId":"NCT01082744","phase":"PHASE3","title":"Thoracic Paravertebral Block for Postoperative Analgesia After Video-assisted Thoracic Surgery.","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2010-03","conditions":"Pain, Postoperative","enrollment":90},{"nctId":"NCT06053476","phase":"NA","title":"Optimal Postoperative Chest Tube and Pain Management in Patients Surgically Treated for Primary Spontaneous Pneumothorax (Pneumotrial)","status":"RECRUITING","sponsor":"Maxima Medical Center","startDate":"2023-11-08","conditions":"Pneumothorax, Primary Spontaneous, VATS, Pain, Postoperative","enrollment":366},{"nctId":"NCT06789744","phase":"NA","title":"Enhanced Recovery After Urologic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xiaguang Duan","startDate":"2025-02-01","conditions":"Circumcision, Hydrocelectomy, Hernia","enrollment":150},{"nctId":"NCT05491239","phase":"NA","title":"Optimal Postoperative Pain Management After Lung Surgery (OPtriAL)","status":"COMPLETED","sponsor":"Maxima Medical Center","startDate":"2021-03-01","conditions":"Lung Cancer, Pain, Postoperative, VATS","enrollment":450},{"nctId":"NCT03396692","phase":"NA","title":"PEF-Block & Ribs Fractures","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2018-06-18","conditions":"Chest Trauma With Ribs Fractures","enrollment":90},{"nctId":"NCT03919422","phase":"NA","title":"Paravertebral Block for Proximal Humeral Fracture Surgery","status":"COMPLETED","sponsor":"Shanghai 6th People's Hospital","startDate":"2019-05-05","conditions":"Proximal Humeral Fracture","enrollment":80},{"nctId":"NCT01949480","phase":"NA","title":"Ultrasound-Assisted Paravertebral Block v. Traditional Paravertebral Block For Pain Control","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2013-07-01","conditions":"Paravertebral Peripheral Nerve Block, Acute Pain Management","enrollment":45},{"nctId":"NCT01404975","phase":"NA","title":"TAVI Protocol - Paravertebral Block Study","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2011-06","conditions":"Aortic Valve Replacement, Aortic Stenosis","enrollment":44},{"nctId":"NCT02192879","phase":"NA","title":"TEA vs. PVB vs. PCA in Liver Resection Surgery","status":"TERMINATED","sponsor":"Duke University","startDate":"2014-08","conditions":"Pain Management Strategies in Liver Resection Surgery","enrollment":10},{"nctId":"NCT02619513","phase":"PHASE4","title":"Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks","status":"COMPLETED","sponsor":"Weifeng Tu","startDate":"2014-12","conditions":"Post-thoracotomy Pain Syndrome","enrollment":60},{"nctId":"NCT01735851","phase":"PHASE4","title":"Comparison of Bilateral Thoracic Paravertebral Block to Thoracic Epidural Analgesia for Post Operative Analgesia in Patients Undergoing Abdominal Surgery","status":"COMPLETED","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2012-12","conditions":"Postoperative Pain","enrollment":70},{"nctId":"NCT00547989","phase":"PHASE3","title":"Paravertebral Block, an Adjunct to General Anaesthesia for Breast Surgery?","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2006-10","conditions":"Breast Cancer","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"additional pvb (ropivacaine)","genericName":"additional pvb (ropivacaine)","companyName":"Maastricht University Medical Center","companyId":"maastricht-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local anesthesia via paravertebral block (Phase 3 investigational use).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}