{"id":"adderall-immediate-release","safety":{"commonSideEffects":[{"rate":"10–30%","effect":"Insomnia"},{"rate":"10–25%","effect":"Decreased appetite"},{"rate":"5–15%","effect":"Headache"},{"rate":"5–15%","effect":"Nervousness or anxiety"},{"rate":"5–10%","effect":"Tachycardia"},{"rate":"5–10%","effect":"Elevated blood pressure"},{"rate":"2–5%","effect":"Tremor"},{"rate":"2–5%","effect":"Dry mouth"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug works by stimulating the release of catecholamines (dopamine and norepinephrine) from presynaptic neurons and inhibiting their reuptake, leading to increased synaptic concentrations. This mechanism enhances executive function, attention, and wakefulness. The immediate-release formulation provides rapid onset of action, typically within 30–60 minutes.","oneSentence":"Adderall is a combination of amphetamine salts that increases the release and blocks the reuptake of dopamine and norepinephrine in the central nervous system, enhancing focus and attention.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:26:39.917Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Attention-deficit/hyperactivity disorder (ADHD)"},{"name":"Narcolepsy"}]},"trialDetails":[{"nctId":"NCT00468143","phase":"PHASE4","title":"A Within-Subject Cross-Over Comparison Between Immediate Release and Extended Release Adderall","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2007-08","conditions":"Attention Deficit Hyperactivity Disorder","enrollment":62}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":105,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Adderall ® Immediate Release","genericName":"Adderall ® Immediate Release","companyName":"NYU Langone Health","companyId":"nyu-langone-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Adderall is a combination of amphetamine salts that increases the release and blocks the reuptake of dopamine and norepinephrine in the central nervous system, enhancing focus and attention. Used for Attention-deficit/hyperactivity disorder (ADHD), Narcolepsy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}