{"id":"adapalene-lotion-vehicle","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Scaling/peeling"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Irritation"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adapalene selectively activates retinoic acid receptor gamma (RARγ) and other retinoid receptors, promoting keratinocyte differentiation and reducing comedone formation. It also exhibits anti-inflammatory properties by modulating cytokine production and immune cell activity in the skin. The lotion vehicle formulation is designed for topical delivery to improve tolerability and efficacy in acne treatment.","oneSentence":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation in acne.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:44:14.135Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT00599521","phase":"PHASE3","title":"Clinical Study to Test the Efficacy and Safety of Adapalene, 0.1%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2007-11","conditions":"Acne Vulgaris","enrollment":1067},{"nctId":"NCT00598832","phase":"PHASE3","title":"Clinical Study to Test the Efficacy and Safety of Adapalene, 0.1%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2007-11","conditions":"Acne Vulgaris","enrollment":1075}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Adapalene Lotion Vehicle","genericName":"Adapalene Lotion Vehicle","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation in acne. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}