{"id":"adapalene-gel-0-1-tazarotene-cream-0-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Dryness and peeling"},{"rate":null,"effect":"Irritation"},{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Burning or stinging"}]},"_chembl":{"chemblId":"CHEMBL335019","moleculeType":"Small molecule","molecularWeight":"339.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adapalene is a naphthoic acid retinoid that binds retinoic acid receptors (RARs) to promote cell turnover and reduce comedone formation. Tazarotene is a acetylenic retinoid that activates RARβ and RARγ to further enhance keratinocyte differentiation and suppress sebum production. Together, they provide synergistic anti-inflammatory and comedolytic effects.","oneSentence":"This combination product delivers two retinoid receptor agonists that normalize skin cell differentiation and reduce inflammation to treat acne and photoaging.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:26:34.953Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"},{"name":"Photoaging and photodamaged skin"}]},"trialDetails":[{"nctId":"NCT00469755","phase":"PHASE4","title":"Differin® Gel x12 Wks vs Tazorac® Cream x12 Wks vs Differin® x6 Wks Switched to Tazorac® x6 Wks for Treatment of Acne","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2006-02","conditions":"Acne Vulgaris","enrollment":302},{"nctId":"NCT00829049","phase":"PHASE4","title":"Safety and Efficacy of Tazarotene Cream 0.1% Compared With Adapalene Gel 0.3% in the Treatment of Moderate to Severe Facial Acne Vulgaris","status":"TERMINATED","sponsor":"Allergan","startDate":"2007-10","conditions":"Acne Vulgaris","enrollment":165}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Differin® Gel, 0.1% and Tazorac® Cream, 0.1%"],"phase":"marketed","status":"active","brandName":"Adapalene Gel, 0.1% + Tazarotene Cream, 0.1%","genericName":"Adapalene Gel, 0.1% + Tazarotene Cream, 0.1%","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product delivers two retinoid receptor agonists that normalize skin cell differentiation and reduce inflammation to treat acne and photoaging. Used for Acne vulgaris, Photoaging and photodamaged skin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}