{"id":"adapalene-benzoyl-peroxide-samples","safety":{"commonSideEffects":[{"rate":"15-25","effect":"Erythema"},{"rate":"10-20","effect":"Scaling/peeling"},{"rate":"10-15","effect":"Dryness"},{"rate":"5-15","effect":"Irritation"},{"rate":"null","effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL1200370","moleculeType":"Small molecule","molecularWeight":"242.23"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adapalene binds to retinoic acid receptors to regulate keratinocyte differentiation and reduce comedone formation. Benzoyl peroxide acts as an oxidizing agent that generates reactive oxygen species to eliminate Cutibacterium acnes (formerly Propionibacterium acnes) and reduce bacterial resistance. The combination provides complementary mechanisms targeting both inflammatory and comedonal acne.","oneSentence":"Adapalene is a retinoid that normalizes skin cell turnover and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:03.686Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT01504204","phase":"PHASE4","title":"Effect of Samples on Acne Treatment With Epiduo® Gel","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2011-12","conditions":"Acne Vulgaris","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Epiduo"],"phase":"marketed","status":"active","brandName":"Adapalene + benzoyl peroxide samples","genericName":"Adapalene + benzoyl peroxide samples","companyName":"Wake Forest University","companyId":"wake-forest-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Adapalene is a retinoid that normalizes skin cell turnover and reduces inflammation, while benzoyl peroxide kills acne-causing bacteria and provides additional antimicrobial activity. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}