{"id":"adapalene-benzoyl-peroxide","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Erythema"},{"rate":"15-25","effect":"Scaling/peeling"},{"rate":"10-20","effect":"Dryness"},{"rate":"10-15","effect":"Irritation"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL1200370","moleculeType":"Small molecule","molecularWeight":"242.23"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adapalene binds to retinoic acid receptors to regulate gene expression, promoting cell turnover and reducing comedone formation. Benzoyl peroxide acts as an oxidizing agent that generates reactive oxygen species to kill Cutibacterium acnes (formerly Propionibacterium acnes) and has keratolytic properties. Together, they provide complementary anti-inflammatory and antimicrobial effects for acne treatment.","oneSentence":"Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide is an antimicrobial that kills acne-causing bacteria and reduces sebum production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:18:25.906Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT07473895","phase":"PHASE2","title":"Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-04","conditions":"Acne Vulgaris","enrollment":40},{"nctId":"NCT07421804","phase":"NA","title":"Evaluation of Topical Dutasteride as a Potential New Therapy for Facial Acne Vulgaris Versus the Triple Combination Therapy (Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel)","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-04","conditions":"Acne Vulgaris","enrollment":50},{"nctId":"NCT07205107","phase":"","title":"Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Triple Combination Gel in Canadian Patients With Acne Vulgaris","status":"RECRUITING","sponsor":"Bausch Health Americas, Inc.","startDate":"2025-10-02","conditions":"Acne Vulgaris","enrollment":200},{"nctId":"NCT07348978","phase":"NA","title":"Auricular Acupressure Combined With Adapalene for the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"University of Medicine and Pharmacy at Ho Chi Minh City","startDate":"2024-11-01","conditions":"Acne Vulgaris","enrollment":64},{"nctId":"NCT05582434","phase":"EARLY_PHASE1","title":"Experience With Topical Acne Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2024-02-15","conditions":"Acne","enrollment":72},{"nctId":"NCT04892706","phase":"PHASE2","title":"Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2021-06-11","conditions":"Acne Vulgaris","enrollment":686},{"nctId":"NCT06336603","phase":"PHASE4","title":"A Study Assessing the Efficacy of Combined Use of Clascoterone 1% Cream and Adapalene 0.3% for the Treatment of Acne","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries Limited","startDate":"2023-11-15","conditions":"Acne Vulgaris","enrollment":20},{"nctId":"NCT07015931","phase":"PHASE1, PHASE2","title":"Efficacy, Safety Profile, and Post-Acne Sequelae of 0.025% Retinoic Acid Cream vs. 0.1% Adapalene Cream in Mild Acne Vulgaris in Fitzpatrick Skin Types III-V","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2024-11-30","conditions":"Acne Vulgaris","enrollment":23},{"nctId":"NCT06673641","phase":"PHASE1","title":"A Study Comparing Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Topical Gel 0.15%;3.1%;1.2% (Taro Pharmaceuticals U.S.A., Inc.) and CABTREO Topical Gel for the Treatment of Acne Vulgaris.","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2024-05-13","conditions":"Acne Vulgaris","enrollment":382},{"nctId":"NCT00422240","phase":"PHASE3","title":"Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2006-06-27","conditions":"Acne Vulgaris","enrollment":1668},{"nctId":"NCT05536882","phase":"PHASE3","title":"MC RCT - BPO vs Adapalene","status":"WITHDRAWN","sponsor":"University of Oklahoma","startDate":"2022-05-18","conditions":"Molluscum Contagiosum","enrollment":""},{"nctId":"NCT02755545","phase":"PHASE4","title":"A Clinical Trial to Evaluate the Efficacy of Two Acne Treatments","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2016-05-01","conditions":"Acne","enrollment":127},{"nctId":"NCT00446043","phase":"PHASE3","title":"Long-term Study of Efficacy/Safety of Adapalene/Benzoyl Peroxide Topical Gel in Acne Vulgaris Subjects","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2004-02-17","conditions":"Acne Vulgaris","enrollment":452},{"nctId":"NCT03076320","phase":"PHASE1, PHASE2","title":"Pirfenidone Plus M-DDO Gel in Moderate and Severe Acne","status":"COMPLETED","sponsor":"University of Guadalajara","startDate":"2017-03-27","conditions":"Acne Vulgaris Superficial Mixed Comedonal and Inflammatory","enrollment":82},{"nctId":"NCT05855629","phase":"NA","title":"\"A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients.\"","status":"UNKNOWN","sponsor":"Treatment and Diagnostic Center of Private Enterprise \"Asklepiy\"","startDate":"2022-02-18","conditions":"Acne Vulgaris","enrollment":59},{"nctId":"NCT05497323","phase":"PHASE1","title":"Effectivity and Safety of Combination Cream of Salicylic Acid, Aqua Posae Filiformis, Niacinamide, Lipohydroxy Acid, Procerad and Zinc PCA","status":"UNKNOWN","sponsor":"Dr.dr.Irma Bernadette, SpKK (K)","startDate":"2022-08-01","conditions":"Acne Vulgaris","enrollment":284},{"nctId":"NCT02899000","phase":"PHASE4","title":"A Treatment for Severe Inflammatory Acne Subjects","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2016-07-29","conditions":"Acne Vulgaris","enrollment":186},{"nctId":"NCT02735421","phase":"PHASE4","title":"Adapalene 0.3% - Benzoyl Peroxide 2.5% Gel and Risk of Formation of Atrophic Acne Scars","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2016-05-13","conditions":"Acne Vulgaris, Atrophic Acne Scars","enrollment":67},{"nctId":"NCT02249104","phase":"PHASE4","title":"A Treatment Regimen for Student Athletes With Mild to Moderate Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2014-08","conditions":"Acne Vulgaris","enrollment":28},{"nctId":"NCT00671749","phase":"PHASE4","title":"Combination Therapy With Differin® Gel 0.3% and Duac® (Clindamycin/Benzoyl Peroxide Gel) in Subjects With Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2007-12","conditions":"Acne Vulgaris","enrollment":100},{"nctId":"NCT01951417","phase":"PHASE4","title":"Adapalene BPO Gel Pump, Moisturizer SPF 30 and Foam Wash in Patients With Mild to Moderate Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2013-10","conditions":"Acne","enrollment":81},{"nctId":"NCT01209949","phase":"PHASE4","title":"Assessment of Subjects' Efficacy and Experiences Using Adapalene BPO Gel in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2010-10","conditions":"Acne Vulgaris","enrollment":30},{"nctId":"NCT00907101","phase":"PHASE4","title":"Evaluate Effectiveness of Epiduo® Gel in Reducing Antibiotic Sensitive & Resistant Strains of Propionibacterium (P)Acnes","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2009-06","conditions":"P Acnes Colonization","enrollment":30},{"nctId":"NCT01522456","phase":"PHASE4","title":"Split-face Tolerability Comparison Between Adapalene-Benzoyl Peroxide Gel Versus Tretinoin Gel","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2012-04","conditions":"Acne Vulgaris","enrollment":73},{"nctId":"NCT05096312","phase":"PHASE4","title":"Effects of Oral Zinc Gluconate Among Acne Vulgaris Patients","status":"COMPLETED","sponsor":"East Avenue Medical Center, Philippines","startDate":"2018-12-21","conditions":"Acne Vulgaris","enrollment":23},{"nctId":"NCT03573115","phase":"NA","title":"Multimodal Optical Imaging for Pretreatment Evaluation for Cutaneous Microparticle Delivery","status":"COMPLETED","sponsor":"Merete Haedersdal","startDate":"2018-01-04","conditions":"Acne Vulgaris, Microparticles","enrollment":16},{"nctId":"NCT05216289","phase":"PHASE4","title":"The Efficacy of an Oral Probiotic Associated With a Fixed Combination of Benzoyl Peroxide and Adapalene in the Treatment of Acne","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2018-04-01","conditions":"Acne Vulgaris","enrollment":400},{"nctId":"NCT03393494","phase":"PHASE3","title":"Bioequivalence Study of Two Treatments in the Treatment of Acne Vulgaris on the Face","status":"COMPLETED","sponsor":"Padagis LLC","startDate":"2017-12-13","conditions":"Acne Vulgaris","enrollment":825},{"nctId":"NCT02525549","phase":"PHASE3","title":"Comparative Safety and Bioequivalence of Two Treatments in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Padagis LLC","startDate":"2011-12","conditions":"Acne","enrollment":903},{"nctId":"NCT03832647","phase":"PHASE4","title":"Anti-acne Efficacy of a Dermo-cosmetic Product Associated With the Fixed Combination Adapalene 0.1%/ Benzoyl Peroxide 2.5% Treatment Versus This Treatment Associated With a Standard Moisturizer in Male and Female Subjects Presenting With Mild to Moderate Acne","status":"COMPLETED","sponsor":"Vichy Laboratoires","startDate":"2019-02-18","conditions":"Acne","enrollment":200},{"nctId":"NCT03563365","phase":"PHASE4","title":"The Functional and Emotional Benefits of Replenix Power of Three With Resveratrol","status":"TERMINATED","sponsor":"Yardley Dermatology Associates","startDate":"2018-06-04","conditions":"Acne Vulgaris","enrollment":43},{"nctId":"NCT00421993","phase":"PHASE3","title":"A Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2006-10","conditions":"Acne Vulgaris","enrollment":1670},{"nctId":"NCT00687908","phase":"PHASE3","title":"Adapalene-Benzoy Peroxide (BPO) Gel in the Treatment of Acne Vulgaris as a 6-month Maintenance","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2008-11","conditions":"Acne","enrollment":243},{"nctId":"NCT02307266","phase":"PHASE4","title":"Patient Education in Adherence on Acne (PEAce)","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2014-11","conditions":"Acne","enrollment":97},{"nctId":"NCT01138735","phase":"PHASE4","title":"Epiduo Pediatric Acne Study","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2010-06","conditions":"Acne","enrollment":285},{"nctId":"NCT01188538","phase":"PHASE4","title":"Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2010-03","conditions":"Acne Vulgaris","enrollment":40},{"nctId":"NCT01106807","phase":"PHASE2","title":"Exploratory Study to Evaluate the Efficacy and Safety of CD07223 Gel in Subjects With Acne","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2010-04","conditions":"Acne","enrollment":73},{"nctId":"NCT00688064","phase":"PHASE3","title":"Adapalene-BPO Gel Associated With Doxycycline Hyclate 100 mg in the Treatment of Severe Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2008-08","conditions":"Severe Acne Vulgaris","enrollment":459},{"nctId":"NCT01014689","phase":"PHASE3","title":"Comparison of Epiduo Associated With Lymecycline Versus Epiduo Vehicle Associated With Lymecycline in Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2009-08","conditions":"Acne Vulgaris","enrollment":378},{"nctId":"NCT01474590","phase":"PHASE3","title":"Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2011-11","conditions":"Acne","enrollment":266},{"nctId":"NCT00883233","phase":"PHASE3","title":"Comparison of Four Different Regimens of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2009-04","conditions":"Acne","enrollment":123},{"nctId":"NCT02932267","phase":"PHASE3","title":"Subject Reported Outcomes With Use of Adapalene 0.3% - Benzoyl Peroxide (BPO) 2.5% in Dark Skin Acne","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2017-02-02","conditions":"Acne Vulgaris","enrollment":50},{"nctId":"NCT00441415","phase":"PHASE3","title":"Efficacy and Safety of Fixed Combination Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2007-02","conditions":"Acne Vulgaris","enrollment":272},{"nctId":"NCT02651220","phase":"PHASE3","title":"Clinical End Point Study of Generic Adapalene and Benzoyl Peroxide Gel Versus Epiduo® Forte Gel in Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2015-11","conditions":"Acne","enrollment":1001},{"nctId":"NCT03650881","phase":"NA","title":"The Comparative Efficacy of an Over the Counter Light Therapy Mask vs Over the Counter Topical Benzoyl Peroxide 2.5% and Used in Combination With Over the Counter Adapalene Gel 0.1% for Mild to Moderate Acne","status":"WITHDRAWN","sponsor":"NYU Langone Health","startDate":"2018-08-07","conditions":"Acne","enrollment":""},{"nctId":"NCT03457636","phase":"PHASE4","title":"The Use of Oracea and Epiduo Forte in Severe Acne Patients","status":"COMPLETED","sponsor":"Derm Research, PLLC","startDate":"2018-03-19","conditions":"Acne","enrollment":22},{"nctId":"NCT02731105","phase":"PHASE4","title":"Pilot Study of Tolerability and Effectivity of Two Combination Topical Acne Products","status":"COMPLETED","sponsor":"GWT-TUD GmbH","startDate":"2015-02","conditions":"Acne Vulgaris","enrollment":22},{"nctId":"NCT01504204","phase":"PHASE4","title":"Effect of Samples on Acne Treatment With Epiduo® Gel","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2011-12","conditions":"Acne Vulgaris","enrollment":20},{"nctId":"NCT00658112","phase":"PHASE4","title":"Measuring Adherence in Subjects With Acne Vulgaris in a Clinic Population Subtitle: Topical Benzoyl Peroxide for Acne","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2006-07","conditions":"Acne Vulgaris","enrollment":20},{"nctId":"NCT02557399","phase":"PHASE4","title":"DUAC® Early Onset Efficacy Study in Japanese Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-10-07","conditions":"Acne Vulgaris","enrollment":350},{"nctId":"NCT00757523","phase":"PHASE4","title":"Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2008-09-10","conditions":"Acne Vulgaris","enrollment":382},{"nctId":"NCT02709902","phase":"PHASE1","title":"Study Comparing Adapalene/BP Gel to EPIDUO® FORTE and Both to a Placebo Control in Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2015-09","conditions":"Acne Vulgaris","enrollment":460},{"nctId":"NCT01742637","phase":"PHASE1","title":"Study Comparing Adapalene and Benzoyl Peroxide Gel 0.1%/2.5% to Epiduo® and Both to a Placebo Control in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2012-10","conditions":"Acne Vulgaris","enrollment":2008},{"nctId":"NCT01910064","phase":"PHASE3","title":"A Long Term Study of GK530G in Subjects With Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2013-05","conditions":"Acne Vulgaris","enrollment":436},{"nctId":"NCT02073448","phase":"PHASE3","title":"Efficacy and Safety Study of GK530G Versus CD0271 0.1% Gel and CD1579 2.5% Gel in the Treatment of Acne Vulgaris.","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2014-03","conditions":"Acne Vulgaris","enrollment":417},{"nctId":"NCT02716090","phase":"PHASE3","title":"Clinical Trial Phase III to Assess the Non-inferiority of Dalap Duo® Product Compared to Epiduo® in the Treatment of Acne Vulgaris","status":"WITHDRAWN","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"","conditions":"Acne Vulgaris","enrollment":""},{"nctId":"NCT00887484","phase":"PHASE4","title":"A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2009-02","conditions":"Acne Vulgaris","enrollment":50},{"nctId":"NCT00964223","phase":"PHASE4","title":"A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2009-07","conditions":"Acne Vulgaris","enrollment":28},{"nctId":"NCT01618773","phase":"","title":"Long-term Study of Epiduo in Patients With Moderate to Severe Acne","status":"COMPLETED","sponsor":"Galderma Laboratorium GmbH","startDate":"2012-06","conditions":"Acne Vulgaris","enrollment":6036},{"nctId":"NCT02338544","phase":"","title":"Application of Epiduo(R) PUMP in Daily Practice in Patients With Inflammatory Acne","status":"COMPLETED","sponsor":"Galderma Laboratorium GmbH","startDate":"2015-01","conditions":"Acne Vulgaris","enrollment":1388},{"nctId":"NCT01220102","phase":"","title":"Efficacy of Epiduo and Treatment Adherence of Adolescent Patients With Inflammatory Acne","status":"COMPLETED","sponsor":"Galderma Laboratorium GmbH","startDate":"2010-05","conditions":"Acne","enrollment":3113},{"nctId":"NCT00926367","phase":"PHASE4","title":"Two-week Study to Compare the Tolerance and Irritation Potential of Two Combination Topical Gel Acne Medications","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2009-05","conditions":"Acne Vulgaris","enrollment":52},{"nctId":"NCT02192632","phase":"NA","title":"Dermatologists' Educational Demonstration for Epiduo Application","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2014-01","conditions":"Facial Acne, Local Adverse Effects","enrollment":85},{"nctId":"NCT01387048","phase":"PHASE4","title":"Study for Long-term Treatment of Acne Vulgaris With Skinoren Versus Differin","status":"COMPLETED","sponsor":"University of Magdeburg","startDate":"2011-08","conditions":"Acne Vulgaris","enrollment":60},{"nctId":"NCT01231334","phase":"PHASE4","title":"A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne","status":"COMPLETED","sponsor":"Allergan","startDate":"2010-08","conditions":"Acne Vulgaris","enrollment":286},{"nctId":"NCT00807014","phase":"PHASE4","title":"Evaluation of Quality of Life, Efficacy, and Tolerance of Duac® Gel Compared to Differin® Gel in the Treatment of Acne","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2006-11","conditions":"Acne Vulgaris","enrollment":169},{"nctId":"NCT01149330","phase":"PHASE4","title":"Evaluation of Efficacy and Safety of Adapalene 0.1%/Benzoyl Peroxide 2.5% Gel in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma Brasil Ltda.","startDate":"2010-07","conditions":"Acne Vulgaris","enrollment":75},{"nctId":"NCT00919191","phase":"PHASE4","title":"Evaluation of Irritation by Two Facial Gels Applied to Opposite Sides of the Face","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2009-04","conditions":"Acne Vulgaris","enrollment":26},{"nctId":"NCT00952523","phase":"PHASE4","title":"Evaluation of Irritation That Potentially Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2009-07","conditions":"Acne Vulgaris","enrollment":162},{"nctId":"NCT00714714","phase":"PHASE4","title":"Evaluation of Irritation That Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face.","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2008-01","conditions":"Acne Vulgaris","enrollment":25},{"nctId":"NCT01501799","phase":"NA","title":"A Bioequivalence Study With Clinical Endpoints Comparing Adapalene and Benzoyl Peroxide Topical Gel 0.1%/2.5% (Actavis Mid-Atlantic LLC) To Epiduo™ (Adapalene and Benzoyl Peroxide) Gel 0.1%/2.5% (Galderma Laboratories, L.P.) in the Treatment of Mild to Severe Acne Vulgaris","status":"COMPLETED","sponsor":"Actavis Mid-Atlantic LLC","startDate":"2011-07","conditions":"Acne Vulgaris","enrollment":885},{"nctId":"NCT00151541","phase":"PHASE3","title":"A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4%","status":"COMPLETED","sponsor":"Allergan","startDate":"2005-02","conditions":"Acne Vulgaris","enrollment":301}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":51,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Epiduo® (adapalene and benzoyl peroxide) Gel 0.1%/2.5%"],"phase":"marketed","status":"active","brandName":"adapalene/benzoyl peroxide","genericName":"adapalene/benzoyl peroxide","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation, while benzoyl peroxide is an antimicrobial that kills acne-causing bacteria and reduces sebum production. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}