{"id":"adapalene-0-1-cream","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Erythema"},{"rate":"10-25","effect":"Scaling/peeling"},{"rate":"5-20","effect":"Dryness"},{"rate":"5-15","effect":"Pruritus"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL1265","moleculeType":"Small molecule","molecularWeight":"412.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adapalene selectively activates retinoic acid receptor gamma (RARγ) and other retinoid receptors, promoting keratinocyte differentiation and reducing sebum production. It decreases comedone formation and has anti-inflammatory properties, making it effective for treating acne by normalizing follicular epithelial desquamation and reducing bacterial colonization.","oneSentence":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:59:37.672Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Evalen®, topical acne agents"],"phase":"phase_3","status":"active","brandName":"Adapalene 0,1% cream","genericName":"Adapalene 0,1% cream","companyName":"Dr.dr.Irma Bernadette, SpKK (K)","companyId":"dr-dr-irma-bernadette-spkk-k","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize skin cell differentiation and reduce inflammation. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}