{"id":"ad036","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"AD036 works by selectively blocking the orexin receptor, which is involved in the regulation of sleep-wake cycles. This leads to increased wakefulness and improved quality of life for patients with narcolepsy. By targeting this specific receptor, AD036 aims to provide a more targeted and effective treatment for this condition.","oneSentence":"AD036 is a small molecule that targets the orexin receptor to treat narcolepsy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:20:47.323Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Narcolepsy"}]},"trialDetails":[{"nctId":"NCT04445688","phase":"PHASE2","title":"Crossover Trial of AD036 in Obstructive Sleep Apnea","status":"COMPLETED","sponsor":"Apnimed","startDate":"2020-07-15","conditions":"Obstructive Sleep Apnea","enrollment":62},{"nctId":"NCT03845023","phase":"PHASE2","title":"Trial of AD036 in Obstructive Sleep Apnea","status":"COMPLETED","sponsor":"Apnimed","startDate":"2019-03-07","conditions":"Obstructive Sleep Apnea","enrollment":140},{"nctId":"NCT04611750","phase":"PHASE2","title":"Pharmacological Intervention for Symptomatic Mild Sleep Disordered Breathing","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2020-12-02","conditions":"Sleep Disordered Breathing","enrollment":53}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["25/5","75/1.5","75/5"],"phase":"phase_2","status":"active","brandName":"AD036","genericName":"AD036","companyName":"Apnimed","companyId":"apnimed","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AD036 is a small molecule that targets the orexin receptor to treat narcolepsy. Used for Narcolepsy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}