{"id":"acular","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or stinging"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Transient corneal erosion"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1201124","moleculeType":"Small molecule","molecularWeight":"376.41"},"_dailymed":{"setId":"c94644d3-7b64-4f3d-a0c7-12c77466a0fc","title":"ACULAR (KETOROLAC TROMETHAMINE) SOLUTION/ DROPS [ALLERGAN, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketorolac works by blocking COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels in ocular tissues, it provides rapid anti-inflammatory and analgesic effects. It is commonly used as an ophthalmic formulation for short-term management of ocular pain and inflammation.","oneSentence":"Acular (ketorolac tromethamine) is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and thereby decrease inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:17:43.863Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ocular pain and inflammation following ophthalmic surgery"},{"name":"Allergic conjunctivitis"},{"name":"Postoperative ocular inflammation"}]},"trialDetails":[{"nctId":"NCT03818932","phase":"PHASE2, PHASE3","title":"Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2019-01-22","conditions":"Anterior Cruciate Ligament Injury","enrollment":90},{"nctId":"NCT06112548","phase":"NA","title":"The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA","status":"COMPLETED","sponsor":"Damascus University","startDate":"2024-03-01","conditions":"Arthritis Knee, Pain, Arthroplasty Complications","enrollment":80},{"nctId":"NCT07480447","phase":"NA","title":"Comparison of Pain Reduction in Painful Chronic Wounds With and Without Fat Grafting","status":"NOT_YET_RECRUITING","sponsor":"King Edward Medical University","startDate":"2026-05-01","conditions":"Wound and Injuries, Pain","enrollment":62},{"nctId":"NCT06201676","phase":"PHASE4","title":"Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-02-28","conditions":"Orthopaedic Trauma, Chronic Opioid Use","enrollment":458},{"nctId":"NCT05992883","phase":"PHASE3","title":"NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2023-07-28","conditions":"Thumb Osteoarthritis","enrollment":240},{"nctId":"NCT05543785","phase":"NA","title":"Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries","status":"RECRUITING","sponsor":"Mansoura University","startDate":"2022-11-01","conditions":"Postoperative Pain, Acute","enrollment":76},{"nctId":"NCT03427736","phase":"","title":"Anesthetics and Analgesics in Children","status":"RECRUITING","sponsor":"Chi Dang Hornik","startDate":"2018-12-13","conditions":"Anesthesia, Pain","enrollment":460},{"nctId":"NCT04505566","phase":"PHASE1","title":"INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Stephen J. 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