{"id":"active-comparator-synovian-inj","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Transient joint effusion"},{"rate":null,"effect":"Local inflammatory reaction"}]},"_chembl":{"chemblId":"CHEMBL3983509","moleculeType":"Small molecule","molecularWeight":"434.92"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Synovian works by supplementing the synovial fluid in the joint space, restoring viscoelastic properties that are depleted in osteoarthritis. The hyaluronic acid provides lubrication and shock absorption, reducing friction between cartilage surfaces and alleviating pain during movement. This viscosupplementation approach aims to improve joint function and delay cartilage degradation.","oneSentence":"Synovian is a hyaluronic acid-based intra-articular injection that lubricates and cushions the joint to reduce pain and improve mobility in osteoarthritis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:06.712Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis of the knee"}]},"trialDetails":[{"nctId":"NCT03561779","phase":"PHASE3","title":"Clinical Trial of YYD302 (Phase3) for Treatment of Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Yooyoung Pharmaceutical Co., Ltd.","startDate":"2018-02-21","conditions":"Osteoarthritis, Knee","enrollment":184}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Synovian Inj."],"phase":"phase_3","status":"active","brandName":"Active comparator: Synovian Inj.","genericName":"Active comparator: Synovian Inj.","companyName":"Yooyoung Pharmaceutical Co., Ltd.","companyId":"yooyoung-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Synovian is a hyaluronic acid-based intra-articular injection that lubricates and cushions the joint to reduce pain and improve mobility in osteoarthritis. Used for Osteoarthritis of the knee.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}