{"id":"active-comparator-euvichol-plus","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL3983509","moleculeType":"Small molecule","molecularWeight":"434.92"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Euvichol-Plus is a killed whole-cell oral cholera vaccine combined with recombinant cholera toxin B subunit (rCTB). It works by inducing mucosal and systemic immune responses against the O1 and O139 serogroups of Vibrio cholerae, providing protection against cholera through both antibody and cellular immunity. The vaccine is administered orally and generates intestinal IgA responses that provide local protection at the site of infection.","oneSentence":"Euvichol-Plus is an oral cholera vaccine that stimulates immune responses against Vibrio cholerae to prevent cholera infection.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:59:08.693Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of cholera caused by Vibrio cholerae O1 and O139 in endemic and epidemic regions"}]},"trialDetails":[{"nctId":"NCT07304284","phase":"PHASE3","title":"Trial to Evaluate Immunogenicity Non-Inferiority, Safety and Lot-to-Lot Consistency of Biovac OCV-S to Euvichol®-Plus","status":"RECRUITING","sponsor":"International Vaccine Institute","startDate":"2025-10-31","conditions":"Cholera Vaccination","enrollment":2824}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Active Comparator, Euvichol®-Plus","genericName":"Active Comparator, Euvichol®-Plus","companyName":"International Vaccine Institute","companyId":"international-vaccine-institute","modality":"Biologic","firstApprovalDate":"","aiSummary":"Euvichol-Plus is an oral cholera vaccine that stimulates immune responses against Vibrio cholerae to prevent cholera infection. Used for Prevention of cholera caused by Vibrio cholerae O1 and O139 in endemic and epidemic regions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}