{"id":"active-bupropion-no-counseling","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Insomnia"},{"rate":"10-20","effect":"Dry mouth"},{"rate":"20-25","effect":"Headache"},{"rate":"10-15","effect":"Nausea"},{"rate":"10-15","effect":"Dizziness"},{"rate":"0.4","effect":"Seizures"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupropion blocks the reuptake of norepinephrine and dopamine at the neuronal synapse, leading to increased concentrations of these neurotransmitters in the central nervous system. This mechanism differs from selective serotonin reuptake inhibitors and is thought to enhance motivation, energy, and reward processing. The drug is used primarily for depression and smoking cessation.","oneSentence":"Bupropion is a norepinephrine-dopamine reuptake inhibitor that increases levels of these neurotransmitters in the brain to improve mood and reduce cravings.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:26:40.762Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Smoking cessation (nicotine dependence)"}]},"trialDetails":[{"nctId":"NCT01621009","phase":"PHASE4","title":"Bupropion SR Plus Counseling for Smoking Cessation","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2001-01","conditions":"Tobacco Dependence, Smoking","enrollment":463}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Active bupropion, No counseling","genericName":"Active bupropion, No counseling","companyName":"University of Wisconsin, Madison","companyId":"university-of-wisconsin-madison","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupropion is a norepinephrine-dopamine reuptake inhibitor that increases levels of these neurotransmitters in the brain to improve mood and reduce cravings. Used for Major depressive disorder, Smoking cessation (nicotine dependence).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}