{"id":"active-bupivacaine-0-375-peng-block","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: tremor, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, arrhythmias)"},{"rate":null,"effect":"Local tissue irritation or nerve injury"},{"rate":"rare","effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1098","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and conduction of nerve impulses, resulting in local anesthesia. The PENG (Pectineus Fascia Iliopsoas Nerve Groove) block is a regional anesthesia technique that delivers bupivacaine to block the femoral and obturator nerves for lower limb anesthesia.","oneSentence":"Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:17:31.263Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia via PENG block for lower limb surgical procedures and pain management"}]},"trialDetails":[{"nctId":"NCT05118620","phase":"PHASE4","title":"Pericapsular Nerve Group Block (PENG) for Hip Surgery","status":"WITHDRAWN","sponsor":"University of California, San Diego","startDate":"2021-12-09","conditions":"Hip Arthropathy, Postoperative Pain, Acute, Pain, Postoperative","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Active Pericapsular Nerve Group block"],"phase":"marketed","status":"active","brandName":"Active bupivacaine 0.375% PENG block","genericName":"Active bupivacaine 0.375% PENG block","companyName":"University of California, San Diego","companyId":"university-of-california-san-diego","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local and regional anesthesia via PENG block for lower limb surgical procedures and pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}