{"id":"acthar-low-dose-40-u","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Increased infection risk"}]},"_chembl":{"chemblId":"CHEMBL2108580","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acthar binds to melanocortin-2 receptors on adrenocortical cells, triggering the release of endogenous glucocorticoids and mineralocorticoids. This endogenous steroid production provides anti-inflammatory and immunosuppressive effects. The low-dose formulation (40 U) is used for chronic conditions requiring sustained but modest corticosteroid activity.","oneSentence":"Acthar is a synthetic adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release cortisol and other corticosteroids.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:02.010Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infantile spasms (West syndrome)"},{"name":"Nephrotic syndrome"},{"name":"Rheumatoid arthritis"},{"name":"Systemic lupus erythematosus"},{"name":"Multiple sclerosis relapse"}]},"trialDetails":[{"nctId":"NCT02779153","phase":"PHASE4","title":"Acthar SLE (Systemic Lupus Erythematosus)","status":"WITHDRAWN","sponsor":"NYU Langone Health","startDate":"2016-10","conditions":"Systemic Lupus Erythematosus (SLE), Repository Corticotropin Injection","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Repository Corticotropin Injection"],"phase":"marketed","status":"active","brandName":"Acthar low dose (40 U)","genericName":"Acthar low dose (40 U)","companyName":"NYU Langone Health","companyId":"nyu-langone-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acthar is a synthetic adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release cortisol and other corticosteroids. Used for Infantile spasms (West syndrome), Nephrotic syndrome, Rheumatoid arthritis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}