{"id":"acthar-gel-80-unt-ml-injectable-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Mood changes / psychiatric effects"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Fluid retention / edema"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ACTH binds to melanocortin-2 receptors on adrenocortical cells, triggering a cascade that increases synthesis and secretion of endogenous glucocorticoids and mineralocorticoids. This endogenous steroid production provides anti-inflammatory and immunosuppressive effects. Unlike exogenous corticosteroids, ACTH stimulation may preserve some aspects of normal adrenal function and circadian rhythm.","oneSentence":"Acthar Gel is a synthetic adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release cortisol and other corticosteroids.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:26:38.944Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infantile spasms (West syndrome)"},{"name":"Nephrotic syndrome"},{"name":"Systemic lupus erythematosus"},{"name":"Rheumatoid arthritis"},{"name":"Acute exacerbations of multiple sclerosis"}]},"trialDetails":[{"nctId":"NCT06964269","phase":"PHASE4","title":"Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease","status":"RECRUITING","sponsor":"Toyos Clinic","startDate":"2025-02-11","conditions":"Autoimmune Diseases, Dry Eye, Neurotrophic Keratitis","enrollment":20},{"nctId":"NCT05546047","phase":"PHASE4","title":"A Study of Acthar Gel Alone or With Tacrolimus to Reduce Proteinuria in Fibrillary Glomerulopathy Patients","status":"UNKNOWN","sponsor":"NephroNet, Inc.","startDate":"2019-03-14","conditions":"Fibrillary Glomerulonephritis","enrollment":34},{"nctId":"NCT04080076","phase":"PHASE4","title":"Comparative and Efficacy Study of ACTHar Gel Alone or in Combination With Tacrolimus in Fibrillary Glomerulopathy","status":"WITHDRAWN","sponsor":"NephroNet, Inc.","startDate":"2019-01-12","conditions":"Renal Disease","enrollment":""},{"nctId":"NCT03408405","phase":"PHASE4","title":"ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children","status":"WITHDRAWN","sponsor":"Rhode Island Hospital","startDate":"2018-06","conditions":"Steroid-Resistant Nephrotic Syndrome","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tacrolimus 1.0 mg","H.P. Acthar gel"],"phase":"marketed","status":"active","brandName":"Acthar Gel 80 UNT/ML Injectable Solution","genericName":"Acthar Gel 80 UNT/ML Injectable Solution","companyName":"NephroNet, Inc.","companyId":"nephronet-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acthar Gel is a synthetic adrenocorticotropic hormone (ACTH) that stimulates the adrenal cortex to produce and release cortisol and other corticosteroids. Used for Infantile spasms (West syndrome), Nephrotic syndrome, Systemic lupus erythematosus.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}