{"id":"acth","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Fluid retention"}]},"_chembl":null,"_dailymed":{"setId":"67d5c665-ca88-49ba-b7d3-7145d9878cf0","title":"PENTACEL (DIPHTHERIA AND TETANUS TOXOIDS AND ACELLULAR PERTUSSIS ADSORBED, INACTIVATED POLIOVIRUS AND HAEMOPHILUS B CONJUGATE (TETANUS TOXOID CONJUGATE) VACCINE) KIT [SANOFI PASTEUR INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ACTH is a peptide hormone that binds to melanocortin-2 receptors on adrenocortical cells, triggering the synthesis and secretion of glucocorticoids (primarily cortisol) and mineralocorticoids. This endogenous hormone replacement or supplementation is used therapeutically to restore cortisol production in adrenal insufficiency or to exploit the immunosuppressive and anti-inflammatory effects of elevated cortisol in certain autoimmune and inflammatory conditions.","oneSentence":"ACTH (adrenocorticotropic hormone) stimulates the adrenal cortex to produce and release cortisol and other corticosteroids.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:26:11.594Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adrenocortical insufficiency (primary and secondary)"},{"name":"Infantile spasms (West syndrome)"},{"name":"Rheumatoid arthritis"},{"name":"Systemic lupus erythematosus"},{"name":"Acute exacerbations of multiple sclerosis"}]},"trialDetails":[{"nctId":"NCT04569591","phase":"NA","title":"DDAVP for Pituitary Adenoma","status":"RECRUITING","sponsor":"National Institute of Neurological Disorders and Stroke 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