{"id":"acne-free-proactiv","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Redness"},{"rate":null,"effect":"Peeling"}]},"_chembl":{"chemblId":"CHEMBL5082715","moleculeType":"Unknown","molecularWeight":"398.50"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"These over-the-counter acne systems typically contain benzoyl peroxide, which kills Cutibacterium acnes (formerly Propionibacterium acnes) bacteria and has antimicrobial properties, combined with salicylic acid, a beta hydroxy acid that exfoliates and unclogs pores. The multi-step regimen is designed to address multiple pathogenic factors of acne including bacterial colonization, sebum production, and follicular hyperkeratinization.","oneSentence":"Proactiv and Acne Free are topical acne treatment systems that work by reducing bacteria, unclogging pores, and reducing inflammation through a combination of benzoyl peroxide and salicylic acid.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:26:29.067Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris (mild to moderate)"}]},"trialDetails":[{"nctId":"NCT00913185","phase":"PHASE4","title":"Comparison Study of Topical Acne Regimens","status":"COMPLETED","sponsor":"MedDerm Associates","startDate":"2006-12","conditions":"Acne","enrollment":128}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Acne Free, Proactiv","genericName":"Acne Free, Proactiv","companyName":"MedDerm Associates","companyId":"medderm-associates","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acne Free and Proactiv are topical acne regimens that have been studied in a clinical trial for the treatment of moderately severe acne vulgaris. The comparison study, completed in 2014, was conducted to evaluate the effectiveness of these two regimens in treating acne.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}