{"id":"acitazanolast","rwe":[],"tags":[{"label":"acitazanolast","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Allergic conjunctivitis","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"zepelin","offLabel":[],"synonyms":["acitazanolast hydrate","WP-871","zepelin","acitazanolast"],"timeline":[],"brandName":"Zepelin","ecosystem":[{"indication":"Allergic conjunctivitis","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alcaftadine","slug":"alcaftadine","company":"Allergan"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"acitazanolast","explanation":"Think of mast cells like the fire alarm in your body. When you're exposed to an allergen, like pollen, it triggers the mast cells to sound the alarm, releasing chemicals that cause inflammation and itching. Acitazanolast silences the fire alarm, reducing the allergic response and relieving symptoms.","oneSentence":"Acitazanolast works by blocking the action of mast cells, which are involved in the allergic response.","technicalDetail":"Acitazanolast is a selective antagonist of the histamine receptor H1, which is involved in the allergic response. By blocking this receptor, acitazanolast inhibits the release of histamine and other mediators from mast cells, reducing inflammation and itching."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Zepelin","title":"Zepelin","extract":"Zepelin is a municipality in the Rostock district, in Mecklenburg-Vorpommern, Germany. It is part of the Amt Bützow Land.","wiki_history":"==History==\nthumb|left|Zepelin Chapel\nThe locality around a village green was founded by German settlers in the 12th century, after the Obotrite area had been conquered by the Saxon duke Henry the Lion. Cepelin in the Duchy of Mecklenburg was first mentioned in a deed issued on 1 May 1246, it was called Zepelin from 1334. A chapel was built in the 14th century, the present-day timber-frame structure was re-built after the devastations in the Thirty Years' War.\n\nOne Heynricus (Henry) de Cepelin appeared in a document executed on 17 September 1286. Already in the late 15th century, the Zep(p)elin noble family, raised to Reichsgrafen in 1792, had moved their residence to nearby Thürkow and Appelhagen. In 1910 a memorial was erected in the honour of Count Ferdinand von Zeppelin (1838–1917) outside the village."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/77","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ACITAZANOLAST","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Zepelin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:25:20.727021","biosimilars":[],"competitors":[],"genericName":"acitazanolast","indications":{"approved":[{"name":"Allergic conjunctivitis","source":"DrugCentral","snomedId":473460002,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"010983","UNII":"99Y8VJ356G","CHEBI":"CHEBI:134948","INN_ID":"7216","UMLSCUI":"C0642373","ChEMBL_ID":"CHEMBL2104654","KEGG_DRUG":"D03233","PUBCHEM_CID":"2006","MESH_DESCRIPTOR_UI":"D011298","MESH_SUPPLEMENTAL_RECORD_UI":"C065288"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zepelin is a small molecule with the synonyms ACITAZANOLAST and ACITAZANOLAST HYDRATE. It has been studied in a clinical trial (NCT02904837) for the treatment of Parkinson's Disease, where it was compared to control training.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}