{"id":"acid-nicotinique","safety":{"commonSideEffects":[{"rate":"50-80","effect":"Flushing"},{"rate":"20-40","effect":"Pruritus"},{"rate":"10-20","effect":"Gastrointestinal upset"},{"rate":"5-15","effect":"Hyperglycemia"},{"rate":"5-10","effect":"Hyperuricemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nicotinic acid is a B vitamin that acts as a ligand for GPR109A (hydroxycarboxylic acid receptor 2) on adipocytes and immune cells, suppressing free fatty acid release and hepatic triglyceride synthesis. This leads to decreased VLDL production and improved lipid profiles. It also has anti-inflammatory properties relevant to cardiovascular disease.","oneSentence":"Nicotinic acid (niacin) reduces triglycerides and LDL cholesterol while raising HDL cholesterol through inhibition of hepatic VLDL production and increased lipolysis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:07.026Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dyslipidemia / mixed hyperlipidemia"},{"name":"Cardiovascular risk reduction in patients with elevated triglycerides and low HDL"}]},"trialDetails":[{"nctId":"NCT00855257","phase":"PHASE3","title":"Assessment of Endothelial Vasomotricity After Treatment by Nicotinic Acid in Acute Coronary Syndrome","status":"COMPLETED","sponsor":"French Cardiology Society","startDate":"2007-06","conditions":"Acute Coronary Syndrome (ACS)","enrollment":93}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Acid Nicotinique","genericName":"Acid Nicotinique","companyName":"French Cardiology Society","companyId":"french-cardiology-society","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nicotinic acid (niacin) reduces triglycerides and LDL cholesterol while raising HDL cholesterol through inhibition of hepatic VLDL production and increased lipolysis. Used for Dyslipidemia / mixed hyperlipidemia, Cardiovascular risk reduction in patients with elevated triglycerides and low HDL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}