{"id":"acexamic-acid","rwe":[{"pmid":"18353035","year":"2008","title":"Allergic contact dermatitis to acexamic acid.","finding":"","journal":"Contact dermatitis","studyType":"Clinical Study"},{"pmid":"8865304","year":"1996","title":"Zinc uptake in five sectors of the rat gastrointestinal tract: kinetic study in the whole colon.","finding":"","journal":"Pharmaceutical research","studyType":"Clinical Study"},{"pmid":"9455471","year":"1996","title":"[The production of nitro esters active at the level of the cardiovascular system].","finding":"","journal":"Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi","studyType":"Clinical Study"},{"pmid":"1982137","year":"1990","title":"Kinetics of the intestinal uptake of zinc acexamate in normal and zinc-depleted rats.","finding":"","journal":"The Journal of pharmacy and pharmacology","studyType":"Clinical Study"},{"pmid":"2100856","year":"1990","title":"[The production of pharmacologically active acexamic acid derivatives. I. The production of acexamic acid and its zinc salt].","finding":"","journal":"Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Skin ulcer","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_3","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"acemin","offLabel":[],"synonyms":["zinc acexamate","sodium acexamate","calcium acexamate","CY168E","epsilon-acetamidocaproic acid","6-(Acetylamino)hexanoic acid","6-Acetamidocaproic acid","6-Acetamidohexanoic acid","acemin","acetaminocaproic acid","acexamic acid"],"timeline":[],"brandName":"Acemin","ecosystem":[{"indication":"Skin ulcer","otherDrugs":[{"name":"sulfadiazine","slug":"sulfadiazine","company":"Lederle"},{"name":"sulfadiazine silver","slug":"sulfadiazine-silver","company":"King Pharms"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your skin ulcers as a wound that needs to heal. Acemin helps to promote the healing process by interacting with the body's natural repair mechanisms, such as increasing blood flow and reducing inflammation. This allows the wound to heal faster and more effectively.","oneSentence":"Acemin works by interacting with specific biological pathways to promote healing in skin ulcers.","technicalDetail":"Acemin is a small molecule that likely works by activating specific ion channels or receptors involved in the regulation of blood flow and inflammation, leading to increased angiogenesis and tissue repair."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3000","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ACEXAMIC%20ACID","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ACEXAMIC ACID","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T07:29:14.677476","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:42:30.135192+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"acexamic acid","indications":{"approved":[{"name":"Skin ulcer","source":"DrugCentral","snomedId":46742003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06434753","phase":"PHASE3","title":"Zinc Supplementation to Improve Prognosis in Patients With Compensated Advanced Chronic Liver Disease.","status":"RECRUITING","sponsor":"Hospital Universitari Vall d'Hebron Research Institute","startDate":"2022-10-02","conditions":["Advanced Chronic Liver Disease","Portal Hypertension","Hepatocellular Carcinoma"],"enrollment":300,"completionDate":"2026-03-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004312","UNII":"7IC4BO7D3R","CHEBI":"CHEBI:134808","INN_ID":"2246","RXNORM":"15978","UMLSCUI":"C0049477","ChEMBL_ID":"CHEMBL2105922","KEGG_DRUG":"D07074","PUBCHEM_CID":"2005","SECONDARY_CAS_RN":"70020-71-2","MESH_SUPPLEMENTAL_RECORD_UI":"C018802"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Dermatology"],"biosimilarFilings":[],"recentPublications":[{"date":"2008 Apr","pmid":"18353035","title":"Allergic contact dermatitis to acexamic acid.","journal":"Contact dermatitis"},{"date":"1996 Aug","pmid":"8865304","title":"Zinc uptake in five sectors of the rat gastrointestinal tract: kinetic study in the whole colon.","journal":"Pharmaceutical research"},{"date":"1996 Jul-Dec","pmid":"9455471","title":"[The production of nitro esters active at the level of the cardiovascular system].","journal":"Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi"},{"date":"1990 Oct","pmid":"1982137","title":"Kinetics of the intestinal uptake of zinc acexamate in normal and zinc-depleted rats.","journal":"The Journal of pharmacy and pharmacology"},{"date":"1990 Apr-Jun","pmid":"2100856","title":"[The production of pharmacologically active acexamic acid derivatives. I. The production of acexamic acid and its zinc salt].","journal":"Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acemin, also known as Aceexamide, is a small molecule drug with unknown drug class and target. It is used to treat skin ulcers and its commercial status is currently unknown. As a small molecule, it is likely to work by interacting with specific biological pathways, but the exact mechanism is not well understood. Further research is needed to determine its safety and efficacy profile. Its development and ownership history are also unclear.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:42:30.135192+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}