{"id":"acetylsalicylic-acid","rwe":[],"_fda":{"id":"472e3862-eab9-2279-e063-6394a90adb4c","set_id":"85a3b808-b476-f2f0-e053-2a91aa0af21f","openfda":{"nui":["N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832","N0000175739","N0000175729","N0000175790","M0023046"],"unii":["R16CO5Y76E","3G6A5W338E","X0A40N8I4S"],"route":["ORAL"],"rxcui":["994535","994537"],"spl_id":["472e3862-eab9-2279-e063-6394a90adb4c"],"brand_name":["Norgesic Forte"],"spl_set_id":["85a3b808-b476-f2f0-e053-2a91aa0af21f"],"package_ndc":["50991-999-60","50991-999-06"],"product_ndc":["50991-999"],"generic_name":["ORPHENADRINE CITRATE, ASPIRIN AND CAFFEINE"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]","Xanthines [CS]"],"pharm_class_pe":["Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]","Central Nervous System Stimulation [PE]"],"substance_name":["ASPIRIN","CAFFEINE","ORPHENADRINE CITRATE"],"pharm_class_epc":["Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]","Central Nervous System Stimulant [EPC]","Methylxanthine [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"manufacturer_name":["Poly Pharmaceuticals, Inc."],"application_number":["ANDA075141"],"is_original_packager":[true]},"version":"9","warnings":["WARNINGS Reye’s Syndrome may develop in individuals who have chicken pox, influenza, or flu symptoms. Some studies suggest possible association between the development of Reye’s Syndrome and the use of medicines containing salicylate or aspirin. Norgesic Forte Tablets 50mg/770mg/60mg contain aspirin and therefore are not recommended for use in patients with chicken pox, influenza, or flu symptoms. Norgesic Forte Tablets may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle: ambulatory patients should therefore be cautioned accordingly. Aspirin should be used with extreme caution in the presence of peptic ulcers and coagulation abnormalities. Usage in Pregnancy Risk Summary Use of NSAIDs, including aspirin, can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment. Because of these risks, limit dose and duration of Orphengesic Forte Tablets use between about 20 and 30 weeks of gestation, and avoid Orphengesic Forte Tablets use at about 30 weeks of gestation and later in pregnancy [see WARNINGS; Fetal Toxicity]. Premature Closure of Fetal Ductus Arteriosus Use of NSAIDs, including aspirin, at about 30 weeks gestation or later in pregnancy increases the risk of premature closure of the fetal ductus arteriosus. Oligohydramnios/Neonatal Renal Impairment Use of NSAIDs at about 20 weeks gestation or later in pregnancy has been associated with cases of fetal renal dysfunction leading to oligohydramnios, and in some cases, neonatal renal impairment. Data from observational studies regarding other potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive. Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization. In animal studies, administration of prostaglandin synthesis inhibitors such as aspirin, resulted in increased pre- and post-implantation loss. Prostaglandins also have been shown to have an important role in fetal kidney development. In published animal studies, prostaglandin synthesis inhibitors have been reported to impair kidney development when administered at clinically relevant doses. The estimated background risk of major birth defects and miscarriage for the indicated population(s) is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively. Clinical Considerations Fetal/Neonatal Adverse Reactions Premature Closure of Fetal Ductus Arteriosus: Avoid use of NSAIDs in women at about 30 weeks gestation and later in pregnancy, because NSAIDs, including Orphengesic Forte Tablets, can cause premature closure of the fetal ductus arteriosus (see WARNINGS; Fetal Toxicity). Oligohydramnios/Neonatal Renal Impairment If an NSAID is necessary at about 20 weeks gestation or later in pregnancy, limit the use to the lowest effective dose and shortest duration possible. If Orphengesic Forte Tablets treatment extends beyond 48 hours, consider monitoring with ultrasound for oligohydramnios. If oligohydramnios occurs, discontinue Orphengesic Forte Tablets and follow up according to clinical practice (see WARNINGS; Fetal Toxicity). Data Human Data Premature Closure of Fetal Ductus Arteriosus : Published literature reports that the use of NSAIDs at about 30 weeks of gestation and later in pregnancy may cause premature closure of the fetal ductus arteriosus. Oligohydramnios/Neonatal Renal Impairment: Published studies and postmarketing reports describe maternal NSAID use at about 20 weeks gestation or later in pregnancy associated with fetal renal dysfunction leading to oligohydramnios, and in some cases, neonatal renal impairment. These adverse outcomes are seen, on average, after days to weeks of treatment, although oligohydramnios has been infrequently reported as soon as 48 hours after NSAID initiation. In many cases, but not all, the decrease in amniotic fluid was transient and reversible with cessation of the drug. There have been a limited number of case reports of maternal NSAID use and neonatal renal dysfunction without oligohydramnios, some of which were irreversible. Some cases of neonatal renal dysfunction required treatment with invasive procedures, such as exchange transfusion or dialysis. Methodological limitations of these postmarketing studies and reports include lack of a control group; limited information regarding dose, duration, and timing of drug exposure; and concomitant use of other medications. These limitations preclude establishing a reliable estimate of the risk of adverse fetal and neonatal outcomes with maternal NSAID use. Because the published safety data on neonatal outcomes involved mostly preterm infants, the generalizability of certain reported risks to the full-term infant exposed to NSAIDs through maternal use is uncertain. Usage in Children The safe and effective use of this drug in children has not been established. Usage of this drug in children under 12 years of age is not recommended. Fetal Toxicity Premature Closure of Fetal Ductus Arteriosus: Avoid use of NSAIDs, including Norgesic Forte Tablets, in pregnant women at about 30 weeks gestation and later. NSAIDs including Orphengesic Forte Tablets, increase the risk of premature closure of the fetal ductus arteriosus at approximately this gestational age. Oligohydramnios/Neonatal Renal Impairment: Use of NSAIDs, including Norgesic Forte Tablets, at about 20 weeks gestation or later in pregnancy may cause fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment. These adverse outcomes are seen, on average, after days to weeks of treatment, although oligohydramnios has been infrequently reported as soon as 48 hours after NSAID initiation. Oligohydramnios is often, but not always, reversible with treatment discontinuation. Complications of prolonged oligohydramnios may, for example, include limb contractures and delayed lung maturation. In some postmarketing cases of impaired neonatal renal function, invasive procedures such as exchange transfusion or dialysis were required. If NSAID treatment is necessary between about 20 weeks and 30 weeks gestation, limit Orphengesic Forte Tablets use to the lowest effective dose and shortest duration possible. Consider ultrasound monitoring of amniotic fluid if Norgesic Forte Tablets treatment extends beyond 48 hours. Discontinue if oligohydramnios occurs and follow up according to clinical practice [see PRECAUTIONS; Pregnancy]. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) has been reported in patients taking NSAIDs such as Orphengesic Forte Tablets. Some of these events have been fatal or life-threatening. DRESS typically, although not exclusively, presents with fever, rash, lymphadenopathy, and/or facial swelling. Other clinical manifestations may include hepatitis, nephritis, hematological abnormalities, myocarditis, or myositis. Sometimes symptoms of DRESS may resemble an acute viral infection. Eosinophilia is often present. Because this disorder is variable in its presentation, other organ systems not noted here may be involved. It is important to note that early manifestations of hypersensitivity, such as fever or lymphadenopathy, may be present even though rash is not evident. If such signs or symptoms are present, discontinue and evaluate the patient immediately."],"description":["DESCRIPTION Each Norgesic Forte tablet, for oral administration, contains Orphenadrine Citrate 50 mg, Aspirin 770 mg, Caffeine 60 mg. In addition, each tablet contains the following inactive ingredients, anhydrous lactous, colloidal silicon dioxide, D&C yellow #10, FD&C blue #1, zinc stearate, providone, pregetanized starch, and stearic acid. Orphenadrine citrate, (2-dimethylaminoethyl 2-methybenzhydryl ether citrate). It is as a white, practically odorless, crystalline powder, having a bitter taste. It is sparingly soluble in water, slightly soluble in alcohol. It has the following structural formula: Aspirin, salicylic acid acetate, is a non-opiate analgesic, anti-inflammatory and antipyretic agent. It occurs as a white, crystalline tabular or needle like powder and is odorless or has a faint odor. It is sparingly soluble in water, freely soluble in alcohol and chloroform. It has the following structural formula: Caffeine is a central nervous system stimulant which occurs as a white powder or white glistening needles, usually matted together. It is sparingly soluble in alcohol, and freely soluble in chloroform. The chemical name for caffeine is 1,3,7-Trimethylxanthine. It has the following structural formula: formula1 formula2 formula3"],"precautions":["PRECAUTIONS Confusion, anxiety and tremors have been reported in a few patients receiving propoxyphene and orphenadrine concomitantly. As these symptoms may be simply due to an additive effect, reduction of dosage and/or discontinuation of one or both agents is recommended in such cases. Safety of continuous long term therapy with Norgesic Forte Tablets has not been established; therefore, if Norgesic Forte Tablets are prescribed for prolonged use, periodic monitoring of blood, urine and liver function values is recommended. Pregnancy Embryo-Fetal Toxicity Inform pregnant women to avoid use of aspirin and other NSAIDs starting at 30 weeks gestation because of the risk of the premature closing of the fetal ductus arteriosus. If treatment with Norgesic Forte Tablets is needed for a pregnant woman between about 20 to 30 weeks gestation, advise her that she may need to be monitored for oligohydramnios, if treatment continues for longer than 48 hours [see WARNINGS; Fetal Toxicity, PRECAUTIONS; Pregnancy]. Serious Skin Reactions, including DRESS Advise patients to stop taking Orphengesic Forte Tablets immediately if they develop any type of rash or fever and to contact their healthcare provider as soon as possible [see Warnings]."],"how_supplied":["HOW SUPPLIED Norgesic Forte Tablets (Orphenadrine Citrate 50mg, Aspirin 770mg, and Caffeine 60mg) Two-layered, white/green capsule shaped, bisected tablets debossed \"GA\" and \"473\" with bisect on the white side and plain on the green side are available in bottles of 60 tablets (NDC 50991-999-60). Store below 30°C (86°F) Rx Only Storage Store at 20°-25°C (68°-77° F) (see USP Controlled Room Temperature). Protect from moisture."],"effective_time":"20251230","adverse_reactions":["ADVERSE REACTIONS Side effects of Norgesic Forte Tablets are those seen with aspirin and caffeine or those usually associated with mild anticholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, and rarely, urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of confusion. Mild central excitation and occasional hallucinations may be observed. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of Orphenadrine Citrate, Aspirin, and Caffeine Tablets has been reported. No causal relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Norgesic Forte Tablets. Some patients may experience transient episodes of lightheadedness, dizziness or syncope."],"contraindications":["CONTRAINDICATIONS Because of the mild anti-cholinergic effect of orphenadrine, Norgesic Forte Tablets should not be used in patients with glaucoma, pyloric or duodenal obstruction, achalasia, prostatic hypertrophy, or obstructions at the bladder neck. Norgesic Forte Tablets are also contraindicated in patients with myasthenia gravis and in patients known to be sensitive to aspirin or caffeine. The drug is contraindicated in patients who have demonstrated a previous hypersensitivity to the drug."],"storage_and_handling":["Storage Store at 20°-25°C (68°-77° F) (see USP Controlled Room Temperature). Protect from moisture."],"clinical_pharmacology":["CLINICAL PHARMACOLOGY Orphenadrine citrate is a centrally acting (brain stem) compound which in animals selectively blocks facilitatory functions of the reticular formulation. Orphenadrine does not produce myoneural block, nor does it affect crossed extensor reflexes. Orphenadrine prevents nicotine-induced convulsions but not those produced by strychnine. Chronic administration of Orphenadrine Citrate, Aspirin, and Caffeine to dogs and rats has revealed no drug-related toxicity. No blood or urine changes were observed, nor were there any macroscopic or microscopic pathological changes detected. Extensive experience with combinations containing aspirin and caffeine has established them as safe agents. The addition of orphenadrine citrate does not alter the toxicity of aspirin and caffeine. The mode of therapeutic action of orphenadrine has not been clearly identified, but may be related to its analgesic properties. Orphenadrine citrate also possesses anticholinergic actions."],"indications_and_usage":["INDICATIONS AND USAGE Norgesic Forte 50 mg/770mg/60 mg Tablets are indicated in: Symptomatic relief of mild to moderate pain of acute musculoskeletal disorders. The orphenadrine component is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. The mode of action of orphenadrine has not been clearly identified, but may be related to its analgesic properties. Norgesic Forte Tablets do not directly relax tense skeletal muscles in man."],"spl_unclassified_section":["Manufactured for: Poly Pharmaceuticals, Inc. Owens Cross Roads, AL 35763 Rev. 04/21"],"dosage_and_administration":["DOSAGE AND ADMINISTRATION Norgesic Forte Tablets: Adults 1/2 to 1 tablet 3 to 4 times daily."],"spl_product_data_elements":["Norgesic Forte Orphenadrine Citrate, Aspirin and Caffeine CROSCARMELLOSE SODIUM FD&C BLUE NO. 1 D&C YELLOW NO. 10 CELLULOSE, MICROCRYSTALLINE POVIDONE SILICON DIOXIDE SODIUM LAURYL SULFATE STARCH, CORN STEARIC ACID ORPHENADRINE CITRATE ORPHENADRINE ASPIRIN ASPIRIN ANHYDROUS LACTOSE CAFFEINE CAFFEINE GA;473"],"package_label_principal_display_panel":["Norgesic Forte Tablet Label Norgesic Forte Tablets 50 mg/770 mg/60 mg Rx only label"]},"tags":[{"label":"Nonsteroidal Anti-inflammatory Drug","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Nicotinate phosphoribosyltransferase","category":"target"},{"label":"NAPRT","category":"gene"},{"label":"PTGS1","category":"gene"},{"label":"PTGS2","category":"gene"},{"label":"M01BA03","category":"atc"},{"label":"Oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Active","category":"status"},{"label":"Arthritic Pain","category":"indication"},{"label":"Backache","category":"indication"},{"label":"Common cold","category":"indication"},{"label":"Headache disorder","category":"indication"},{"label":"Influenza-like symptoms","category":"indication"},{"label":"Joint pain","category":"indication"},{"label":"Endo Pharms","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antipyretics","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Cyclooxygenase Inhibitors","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Fibrinolytic Agents","category":"pharmacology"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Platelet Aggregation Inhibitors","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"marketed","fdaNDC":[{"route":[],"labeler":"RMC Performance Chemicals Private Limited","brandName":"","packaging":[],"dosageForm":"POWDER","genericName":"Aspirin / Acetylsalicylic Acid","productType":"BULK INGREDIENT","activeIngredients":[{"name":"ACETYLSALICYLIC ACID","strength":"1 kg/kg"}],"marketingCategory":"BULK INGREDIENT"}],"safety":{"boxedWarnings":["This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:oare age 60 or olderohave had stomach ulcers or bleeding problemsotake blood thinning (anticoagulant) or steroid drugotake other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or othersohave or more alcoholic drinks every day while using this productotake more or for longer time that directed. ohives. ofacial swelling. oshock. oasthma (wheezing). oare age 6"],"safetySignals":[{"llr":3318.208,"date":"","count":8674,"signal":"Gastrointestinal haemorrhage","source":"DrugCentral FAERS","actionTaken":"Reported 8,674 times (LLR=3318)"},{"llr":3267.628,"date":"","count":10126,"signal":"Myocardial infarction","source":"DrugCentral FAERS","actionTaken":"Reported 10,126 times (LLR=3268)"},{"llr":3065.879,"date":"","count":16457,"signal":"Drug ineffective","source":"DrugCentral FAERS","actionTaken":"Reported 16,457 times (LLR=3066)"},{"llr":2202.749,"date":"","count":4584,"signal":"Coronary artery disease","source":"DrugCentral FAERS","actionTaken":"Reported 4,584 times (LLR=2203)"},{"llr":1999.775,"date":"","count":4613,"signal":"Acute myocardial infarction","source":"DrugCentral FAERS","actionTaken":"Reported 4,613 times (LLR=2000)"},{"llr":1903.532,"date":"","count":2504,"signal":"Labelled drug-drug interaction medication error","source":"DrugCentral FAERS","actionTaken":"Reported 2,504 times (LLR=1904)"},{"llr":1389.748,"date":"","count":7041,"signal":"Cerebrovascular accident","source":"DrugCentral FAERS","actionTaken":"Reported 7,041 times (LLR=1390)"},{"llr":1373.426,"date":"","count":1751,"signal":"Treatment failure","source":"DrugCentral FAERS","actionTaken":"Reported 1,751 times (LLR=1373)"},{"llr":1336.294,"date":"","count":15278,"signal":"Off label use","source":"DrugCentral FAERS","actionTaken":"Reported 15,278 times (LLR=1336)"},{"llr":1266.058,"date":"","count":6283,"signal":"Cardiac failure congestive","source":"DrugCentral FAERS","actionTaken":"Reported 6,283 times (LLR=1266)"},{"llr":1162.458,"date":"","count":3099,"signal":"Angina pectoris","source":"DrugCentral FAERS","actionTaken":"Reported 3,099 times (LLR=1162)"},{"llr":1137.884,"date":"","count":3453,"signal":"Alopecia","source":"DrugCentral FAERS","actionTaken":"Reported 3,453 times (LLR=1138)"},{"llr":1073.918,"date":"","count":3119,"signal":"Melaena","source":"DrugCentral FAERS","actionTaken":"Reported 3,119 times (LLR=1074)"},{"llr":987.631,"date":"","count":2371,"signal":"Upper gastrointestinal haemorrhage","source":"DrugCentral FAERS","actionTaken":"Reported 2,371 times (LLR=988)"},{"llr":981.134,"date":"","count":1427,"signal":"Pemphigus","source":"DrugCentral FAERS","actionTaken":"Reported 1,427 times (LLR=981)"}],"drugInteractions":[{"url":"/drug/celecoxib","drug":"celecoxib","action":"Monitor closely","effect":"May interact with Aspirin, Celecoxib","source":"DrugCentral","drugSlug":"celecoxib"},{"url":"/drug/dicoumarol","drug":"dicoumarol","action":"Monitor closely","effect":"May interact with Aspirin, Dicumarol","source":"DrugCentral","drugSlug":"dicoumarol"},{"url":"/drug/heparin","drug":"heparin","action":"Monitor closely","effect":"May interact with Aspirin, Heparin","source":"DrugCentral","drugSlug":"heparin"},{"url":"/drug/ibuprofen","drug":"ibuprofen","action":"Monitor closely","effect":"May interact with Aspirin, Ibuprofen","source":"DrugCentral","drugSlug":"ibuprofen"},{"url":"/drug/methotrexate","drug":"methotrexate","action":"Avoid combination","effect":"May interact with Aspirin, Methotrexate","source":"DrugCentral","drugSlug":"methotrexate"},{"url":"/drug/phenprocoumon","drug":"phenprocoumon","action":"Monitor closely","effect":"May interact with Aspirin, Phenprocoumon","source":"DrugCentral","drugSlug":"phenprocoumon"},{"url":"/drug/probenecid","drug":"probenecid","action":"Monitor closely","effect":"May interact with Aspirin, Probenecid","source":"DrugCentral","drugSlug":"probenecid"},{"url":"/drug/rofecoxib","drug":"rofecoxib","action":"Monitor closely","effect":"May interact with Aspirin, Rofecoxib","source":"DrugCentral","drugSlug":"rofecoxib"},{"url":"/drug/sulfinpyrazone","drug":"sulfinpyrazone","action":"Monitor closely","effect":"May interact with Aspirin, Sulfinpyrazone","source":"DrugCentral","drugSlug":"sulfinpyrazone"},{"url":"/drug/valdecoxib","drug":"valdecoxib","action":"Monitor closely","effect":"May interact with Aspirin, Valdecoxib","source":"DrugCentral","drugSlug":"valdecoxib"},{"url":"/drug/valproic-acid","drug":"valproic acid","action":"Monitor closely","effect":"May interact with Aspirin, Valproic Acid","source":"DrugCentral","drugSlug":"valproic-acid"},{"url":"/drug/warfarin","drug":"warfarin","action":"Monitor closely","effect":"May interact with Aspirin, Warfarin","source":"DrugCentral","drugSlug":"warfarin"}],"commonSideEffects":[{"effect":"pyrexia","drugRate":"17.6%","organSystem":"General disorders","placeboRate":"","totalAtRisk":17,"totalAffected":3,"trialsReporting":1},{"effect":"Headache","drugRate":"37.5%","organSystem":"Nervous system disorders","placeboRate":"","totalAtRisk":8,"totalAffected":3,"trialsReporting":1},{"effect":"Nausea/Nausea and Vomiting","drugRate":"37.5%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":3,"trialsReporting":1},{"effect":"Abdominal pain/Abdominal pain with Bloating","drugRate":"25.0%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":2,"trialsReporting":1},{"effect":"Cough/Cough due to Cold Symptoms","drugRate":"25.0%","organSystem":"Respiratory, thoracic and mediastinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":2,"trialsReporting":1},{"effect":"Flu like symptoms(Sick/Cough due to cold symptoms/Nasal and chest congestion)","drugRate":"25.0%","organSystem":"General disorders","placeboRate":"","totalAtRisk":8,"totalAffected":2,"trialsReporting":1},{"effect":"Acid Reflux","drugRate":"12.5%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Arthritis","drugRate":"12.5%","organSystem":"Musculoskeletal and connective tissue disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Back pain","drugRate":"12.5%","organSystem":"Musculoskeletal and connective tissue disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Chills","drugRate":"12.5%","organSystem":"General disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Constipation","drugRate":"12.5%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Dizziness","drugRate":"12.5%","organSystem":"Nervous system disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Edema-Limbs","drugRate":"12.5%","organSystem":"General disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Ganglion Cyst Left Finger","drugRate":"12.5%","organSystem":"Musculoskeletal and connective tissue disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Gastrointestinal Disorders-Other, specify:Mouth Sores","drugRate":"12.5%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"PSA out of range","drugRate":"12.5%","organSystem":"Investigations","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Left rotator cuff tear due to fall","drugRate":"12.5%","organSystem":"Injury, poisoning and procedural complications","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Surgical and Medical Procedures-Other, specify-Radiation Therapy","drugRate":"12.5%","organSystem":"Surgical and medical procedures","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Gastrointestinal Disorders-Other, specify: dental crown recemented","drugRate":"12.5%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Runny Nose","drugRate":"12.5%","organSystem":"General disorders","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Rotator Cuff Repair","drugRate":"12.5%","organSystem":"Surgical and medical procedures","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"Diverticulitis","drugRate":"12.5%","organSystem":"Infections and infestations","placeboRate":"","totalAtRisk":8,"totalAffected":1,"trialsReporting":1},{"effect":"bradycardia","drugRate":"0.0%","organSystem":"Cardiac disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"Bruise","drugRate":"0.0%","organSystem":"General disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"epigastric pain","drugRate":"0.0%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"hypokalaemia","drugRate":"0.0%","organSystem":"Endocrine disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"Bleeding","drugRate":"0.0%","organSystem":"Blood and lymphatic system disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"pinpoint pain","drugRate":"0.0%","organSystem":"Injury, poisoning and procedural complications","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"cold sores","drugRate":"0.0%","organSystem":"Infections and infestations","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"hypertension","drugRate":"0.0%","organSystem":"Cardiac disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"Covid-19 infection","drugRate":"0.0%","organSystem":"Infections and infestations","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"dyspepsia","drugRate":"0.0%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"nausea","drugRate":"0.0%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"foot injury","drugRate":"0.0%","organSystem":"Injury, poisoning and procedural complications","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"excess phleghm","drugRate":"0.0%","organSystem":"Respiratory, thoracic and mediastinal disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"migraine","drugRate":"0.0%","organSystem":"Nervous system disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"fall","drugRate":"0.0%","organSystem":"Injury, poisoning and procedural complications","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"vasovagal episode","drugRate":"0.0%","organSystem":"Nervous system disorders","placeboRate":"","totalAtRisk":17,"totalAffected":0,"trialsReporting":1},{"effect":"Arthralgia","drugRate":"0.0%","organSystem":"Musculoskeletal and connective tissue disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Blood in Stool","drugRate":"0.0%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Bruising left arm","drugRate":"0.0%","organSystem":"Skin and subcutaneous tissue disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Cataract Removed","drugRate":"0.0%","organSystem":"Eye disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Diarrhea","drugRate":"0.0%","organSystem":"Gastrointestinal disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Eye Pain-Herpes Virus Right Eye","drugRate":"0.0%","organSystem":"Eye disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Fall","drugRate":"0.0%","organSystem":"Injury, poisoning and procedural complications","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Fatigue","drugRate":"0.0%","organSystem":"General disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Fusion of Right Great Toe Joint","drugRate":"0.0%","organSystem":"Surgical and medical procedures","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Gout","drugRate":"0.0%","organSystem":"Musculoskeletal and connective tissue disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Pain","drugRate":"0.0%","organSystem":"General disorders","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1},{"effect":"Sinusitis","drugRate":"0.0%","organSystem":"Infections and infestations","placeboRate":"","totalAtRisk":8,"totalAffected":0,"trialsReporting":1}],"contraindications":["Glaucoma","Pyloric or duodenal obstruction","Achalasia","Prostatic hypertrophy","Obstructions at the bladder neck","Myasthenia gravis","Known sensitivity to aspirin or caffeine","Previous hypersensitivity to the drug"],"specialPopulations":{"Pregnancy":"May cause fetal harm. Prolonged use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome. Use of aspirin, including ASCOMP with CODEINE, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. Available data with ASCOMP with CODEINE in pregnant women is insufficient to inform drug-associated risk for major birth defects and miscarriage. Animal reproduction studies have not been conducted with the combination of butalbital, acetaminophen, caffeine, and codeine phosphate capsules or with butalbital alone. In animal reproduction studies, codeine administration during organogenesis has been shown to produce delayed ossification in the offspring of mice at 2.8 times maximum recommended human dose (MRHD) of 180 mg/day, embryolethal and fetotoxic effects in the offspring of rats and hamsters at approximately to times the MRHD, and cranial malformations/cranioschisis in the offspring of hamsters between and times the MRHD. Based on animal data, prostaglandins have been shown to have an important role in endometrial vasc. Although there is no clearly defined risk, such experience cannot exclude the possibility of infreque","Geriatric use":"Clinical studies of Carisoprodol, Aspirin, and Codeine Phosphate Tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of","Paediatric use":"Safety and effectiveness of Methocarbamol and Aspirin Tablets in pediatric patients below the age of 12 have not been established."},"seriousAdverseEvents":[{"event":"Parotidectomy","detail":"Surgical and medical procedures. 1 trial(s).","severity":"serious","incidence":"12.5%"},{"event":"Small Bowel Obstruction","detail":"Gastrointestinal disorders. 1 trial(s).","severity":"serious","incidence":"12.5%"},{"event":"Hiatus Hernia Repair","detail":"Surgical and medical procedures. 1 trial(s).","severity":"serious","incidence":"12.5%"},{"event":"Subdural Hematoma","detail":"Vascular disorders. 1 trial(s).","severity":"serious","incidence":"0.0%"},{"event":"Drainage of Subdural Hematoma","detail":"Surgical and medical procedures. 1 trial(s).","severity":"serious","incidence":"0.0%"},{"event":"Severe Stenosis","detail":"Musculoskeletal and connective tissue disorders. 1 trial(s).","severity":"serious","incidence":"0.0%"}]},"trials":[],"aliases":["ASA","aspirin","Aspirin","Cardirene","Aspirin(Bayer)"],"company":"Endo","patents":[{"source":"FDA Orange Book via DrugCentral","expires":"2033-03-13","territory":"US","patentNumber":"9539214"},{"source":"FDA Orange Book via DrugCentral","expires":"2033-01-02","territory":"US","patentNumber":"9987231"},{"source":"FDA Orange Book via DrugCentral","expires":"2032-09-29","territory":"US","patentNumber":"10646431"},{"source":"FDA Orange Book via DrugCentral","expires":"2032-09-29","territory":"US","patentNumber":"10786444"},{"source":"FDA Orange Book via DrugCentral","expires":"2032-09-29","territory":"US","patentNumber":"9216150"},{"source":"FDA Orange Book via DrugCentral","expires":"2032-09-29","territory":"US","patentNumber":"9226892"},{"source":"FDA Orange Book via DrugCentral","expires":"2023-02-28","territory":"US","patentNumber":"6926907"},{"source":"FDA Orange Book via DrugCentral","expires":"2023-02-28","territory":"US","patentNumber":"8206741"}],"pricing":[],"_sources":{"_fda":{"url":"","method":"api_direct","source":"FDA OpenFDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T07:54:30.790665+00:00"},"fdaNDC":{"url":"","method":"api_direct","source":"FDA NDC Directory","rawText":"","confidence":1,"sourceType":"fda_ndc","retrievedAt":"2026-04-19T19:07:30.774517+00:00"},"patents":{"url":"","method":"deterministic","source":"FDA Orange Book + Purple Book","rawText":"","confidence":1,"sourceType":"fda_orange_book","retrievedAt":"2026-04-19T19:07:45.681861+00:00"},"dailyMed":{"url":"","method":"api_direct","source":"DailyMed (NIH/NLM)","rawText":"","confidence":1,"sourceType":"dailymed","retrievedAt":"2026-04-19T19:07:31.499421+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"Haiku strategic summary","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T07:54:33.337672+00:00"},"mechanism":{"url":"","method":"ai_extraction","source":"FDA Label + Haiku","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T08:25:11.970970+00:00"},"chemblData":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2429949/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T19:07:38.344980+00:00"},"trialDetails":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (0 trials with endpoints)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T19:07:58.700986+00:00"},"publicationCount":{"url":"","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T19:07:36.278232+00:00"},"recentPublications":{"url":"","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T19:07:37.215384+00:00"},"rxnormFormulations":{"url":"https://rxnav.nlm.nih.gov/REST/drugs.json?name=acetylsalicylic acid","method":"api_direct","source":"RxNorm (NIH)","rawText":"","confidence":1,"sourceType":"rxnorm","retrievedAt":"2026-04-19T19:07:30.376703+00:00"},"participantFlowData":{"url":"","method":"deterministic","source":"ClinicalTrials.gov participantFlowModule","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T19:07:58.700917+00:00"},"structuredTrialResults":{"url":"","method":"deterministic","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-20T07:54:29.504673+00:00"},"safety.commonSideEffects":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (2 trials)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-20T08:25:12.330576+00:00"},"safety.contraindications":{"url":"","method":"ai_extraction","source":"FDA Label + Haiku","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T07:54:33.337654+00:00"},"safety.seriousAdverseEvents":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (2 trials)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-20T07:54:29.504665+00:00"}},"allNames":"norgesic","dailyMed":[{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2a2d24dd-ef82-6293-e054-00144ff8d46c","setid":"2a2d24dd-ef82-6293-e054-00144ff8d46c","title":"CARDIOASPIRINA TABLETAS CON CUBIERTA ENTERICA (ACETYLSALICYLIC ACID) TABLET, COATED [BAYER HEALTHCARE LLC]"},{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4430cfb-3968-46a0-bb09-78b2cc0cd19b","setid":"a4430cfb-3968-46a0-bb09-78b2cc0cd19b","title":"FIRST CHOICE ASPIRIN BOLUS - 480GRS (ACETYLSALICYLIC ACID) TABLET [CONTRACT MANUFACTURING SERVICES, LLC]"},{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fbc5d9bf-eae2-4743-81e7-0b622a147711","setid":"fbc5d9bf-eae2-4743-81e7-0b622a147711","title":"AQUASOURCE ASPIRIN POWDER (ACETYLSALICYLIC ACID) POWDER [BLENDPACK, INC.]"},{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=030fb565-2006-a4c3-e063-6394a90a3505","setid":"030fb565-2006-a4c3-e063-6394a90a3505","title":"ACETYLSALICYLIC ACID COATED (ASPIRIN) TABLET [4MEDICAL GROUP, LLC]"},{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1350712f-3be8-4e0e-8686-23d4295194fe","setid":"1350712f-3be8-4e0e-8686-23d4295194fe","title":"FIRST CHOICE DAIRY SUPPLY ASPIRIN BOLUS (ACETYLSALICYLIC ACID) TABLET [CONTRACT MANUFACTURING SERVICES, LLC]"}],"offLabel":[],"synonyms":["acetylsalisylic acid","aspirin","acetylsalicylic acid","aspirin sodium","aspirin magnesium","aspirin potassium","aspirin calcium","aspirin anhydride","aspirin lysine"],"timeline":[{"date":"1898-01-01","type":"positive","source":"DrugCentral","milestone":"YEAR INTRODUCED approval"},{"date":"1950-04-12","type":"positive","source":"DrugCentral","milestone":"FDA approval (Endo Pharms)"}],"variants":[{"slug":"aspirin","route":"Oral","brandName":"Aspirin","description":"Aspirin","formulation":"Tablet, Enteric-coated tablet, Chewable tablet"}],"aiSummary":"Norgesic Forte combines orphenadrine citrate, aspirin, and caffeine for symptomatic relief of mild to moderate acute musculoskeletal pain. The orphenadrine component acts centrally on the brain stem reticular formation and possesses anticholinergic properties. Contraindications include glaucoma, urinary/GI obstructions, myasthenia gravis, and hypersensitivity to aspirin or caffeine. Long-term animal studies demonstrated safety with no toxicity or pathological changes observed.","brandName":"Aspirin","ecosystem":[{"indication":"Arthritic Pain","otherDrugs":[{"name":"camphor","slug":"camphor","company":""},{"name":"capsaicin","slug":"capsaicin","company":"Acorda"},{"name":"levomenthol","slug":"levomenthol","company":""},{"name":"methyl salicylate","slug":"methyl-salicylate","company":"Hisamitsu Pharm Co"}],"globalPrevalence":null},{"indication":"Backache","otherDrugs":[{"name":"aceclofenac","slug":"aceclofenac","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"camphor","slug":"camphor","company":""},{"name":"capsaicin","slug":"capsaicin","company":"Acorda"}],"globalPrevalence":null},{"indication":"Common cold","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"azatadine","slug":"azatadine","company":""},{"name":"bromazine","slug":"bromazine","company":"Forest Labs"}],"globalPrevalence":null},{"indication":"Headache disorder","otherDrugs":[{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"citric acid","slug":"citric-acid","company":"Baxter Hlthcare"},{"name":"codeine","slug":"codeine","company":"Ani Pharms"},{"name":"dextromethorphan","slug":"dextromethorphan","company":"Ani Pharms"}],"globalPrevalence":1400000000},{"indication":"Influenza-like symptoms","otherDrugs":[{"name":"brompheniramine","slug":"brompheniramine","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"chlorphenamine","slug":"chlorphenamine","company":"Bayer Healthcare Llc"},{"name":"codeine","slug":"codeine","company":"Ani Pharms"}],"globalPrevalence":null},{"indication":"Joint pain","otherDrugs":[{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"magnesium salicylate","slug":"magnesium-salicylate","company":""},{"name":"methyl nicotinate","slug":"methyl-nicotinate","company":""},{"name":"naproxen","slug":"naproxen","company":"Roche Palo"}],"globalPrevalence":null},{"indication":"Migraine","otherDrugs":[{"name":"almotriptan","slug":"almotriptan","company":"Janssen Pharms"},{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"dihydroergotamine","slug":"dihydroergotamine","company":"Valeant"},{"name":"eletriptan","slug":"eletriptan","company":"Pfizer Ireland"}],"globalPrevalence":1000000000},{"indication":"Myocardial infarction","otherDrugs":[{"name":"atenolol","slug":"atenolol","company":"Alvogen Ipco Sarl"},{"name":"dicoumarol","slug":"dicoumarol","company":"Abbvie"},{"name":"enoxaparin sodium","slug":"enoxaparin-sodium","company":"Sanofi Aventis Us"},{"name":"lisinopril","slug":"lisinopril","company":"Merck"}],"globalPrevalence":523000000}],"mechanism":{"target":"reticular formation (brain stem)","novelty":"First-in-class","targets":[{"gene":"NAPRT","source":"DrugCentral","target":"Nicotinate phosphoribosyltransferase","protein":"Nicotinate phosphoribosyltransferase"},{"gene":"PTGS1","source":"DrugCentral","target":"Prostaglandin G/H synthase 1","protein":"Prostaglandin G/H synthase 1"},{"gene":"PTGS2","source":"DrugCentral","target":"Prostaglandin G/H synthase 2","protein":"Prostaglandin G/H synthase 2"},{"gene":"GGT1","source":"DrugCentral","target":"Gamma-glutamyltranspeptidase 1","protein":"Gamma-glutamyltranspeptidase 1"},{"gene":"ASIC3","source":"DrugCentral","target":"Acid-sensing ion channel 3","protein":"Acid-sensing ion channel 3"}],"moaClass":"Cyclooxygenase Inhibitors","modality":"CNS depressant","drugClass":"centrally acting muscle relaxant with anticholinergic properties","explanation":"Orphenadrine citrate is a centrally acting compound that selectively blocks facilitatory functions of the reticular formation in the brain stem. The drug does not produce myoneural block or affect crossed extensor reflexes. The exact mode of therapeutic action has not been clearly identified but may be related to its analgesic properties. Orphenadrine also possesses anticholinergic actions. In combination with aspirin and caffeine, chronic administration studies in animals showed no drug-related toxicity, blood or urine changes, or pathological changes.","oneSentence":"Orphenadrine citrate centrally acts on brain stem to selectively block facilitatory reticular functions.","technicalDetail":"Norgesic, containing acetylsalicylic acid, acts as a non-selective COX inhibitor, blocking the conversion of arachidonic acid to prostaglandins, thereby reducing inflammation and pain."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Aspirin","title":"Aspirin","extract":"Aspirin is the genericized trademark for acetylsalicylic acid (ASA), a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation, and as an antithrombotic. Aspirin is used to treat inflammatory conditions including Kawasaki disease, pericarditis, and rheumatic fever.","wiki_history":"==History==\n\nthumb|left|1923 advertisement\n<!-- DO NOT PUT NEW CONTENT HERE. PLEASE UPDATE THE BODY OF HISTORY OF ASPIRIN AND UPDATE THE LEAD, AND COPY THAT LEAD HERE -->\nMedicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. Hippocrates referred to the use of salicylic tea to reduce fevers around 400 BC, and willow bark preparations were part of the pharmacopoeia of Western medicine in classical antiquity and the Middle Ages. after the Rev Edward Stone of Chipping Norton, Oxfordshire, noticed that the bitter taste of willow bark resembled the taste of the bark of the cinchona tree, known as \"Peruvian bark\", which was used successfully in Peru to treat a variety of ailments. Stone experimented with preparations of powdered willow bark on people in Chipping Norton for five years and found it to be as effective as Peruvian bark and a cheaper domestic version. In 1763, he sent a report of his findings to the Royal Society in London. By the nineteenth century, pharmacists were experimenting with and prescribing a variety of chemicals related to salicylic acid, the active component of willow extract.\n\nAspirin sales revived considerably in the last decades of the 20th century, and remain strong in the 21st century with widespread use as a preventive treatment for heart attacks and strokes. Aspirin is a generic trademark in many countries. Aspirin, with a capital \"A\", remains a registered trademark of Bayer in Germany, Canada, Mexico, and over 80 other countries, for acetylsalicylic acid in all markets, but using different packaging and physical aspects for each.\n\n===Compendial status===\n* United States Pharmacopeia\n* British Pharmacopoeia"},"chemblData":{"prodrug":-1,"chemblId":"CHEMBL2429949","maxPhase":null,"chirality":-1,"parenteral":false,"availability":-1,"moleculeType":"Small molecule","withdrawnFlag":false,"naturalProduct":0,"blackBoxWarning":0,"oralBioavailable":false},"commercial":{"launchDate":"1950","_launchSource":"DrugCentral (FDA 1950-04-12, ENDO PHARMS)"},"fdaRecalls":[],"references":[{"id":1,"url":"https://drugcentral.org/drugcard/74","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=acetylsalicylic%20acid","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=acetylsalicylic acid","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Aspirin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:25:05.550434","_validation":{"fieldsValidated":6,"lastValidatedAt":"2026-04-20T08:25:14.368402+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"phenylbutazone","drugSlug":"phenylbutazone","fdaApproval":"1980-01-10","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://tavily.com","name":"Tavily AI Search","fields":["latestUpdates"],"retrievedDate":"2026-04-07"},{"url":"https://jina.ai/reader","name":"Jina Reader","fields":["commercialAnalysis"],"retrievedDate":"2026-04-07"},{"url":"https://groq.com","name":"Groq (Llama 3.1 8B)","fields":["commercialAnalysis"],"retrievedDate":"2026-04-07"}],"genericName":"acetylsalicylic acid","indications":{"approved":[{"name":"Arthritic Pain","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":"adults and children over 3 years old, as recommended by doctor"},{"name":"Backache","source":"DrugCentral","snomedId":161891005,"regulator":"FDA","eligibility":"not specified"},{"name":"Common cold","source":"DrugCentral","snomedId":82272006,"regulator":"FDA","eligibility":"not specified"},{"name":"Headache disorder","source":"DrugCentral","snomedId":230461009,"regulator":"FDA","eligibility":"not specified","usPrevalence":null,"globalPrevalence":1400000000,"prevalenceMethod":"curated","prevalenceSource":"Cell Mol Neurobiol, 2023 (PMID:17381554)"},{"name":"Influenza-like symptoms","source":"DrugCentral","snomedId":315642008,"regulator":"FDA","eligibility":"not specified"},{"name":"Joint pain","source":"DrugCentral","snomedId":57676002,"regulator":"FDA","eligibility":"not specified"},{"name":"Migraine","source":"DrugCentral","snomedId":37796009,"regulator":"FDA","eligibility":"not specified","usPrevalence":39000000,"globalPrevalence":1000000000,"prevalenceMethod":"curated","prevalenceSource":"Lancet Neurology, 2023"},{"name":"Myocardial infarction","source":"DrugCentral","snomedId":22298006,"regulator":"FDA","eligibility":"not specified","usPrevalence":null,"globalPrevalence":523000000,"prevalenceMethod":"curated","prevalenceSource":"WHO CVD Factsheet, 2023"},{"name":"Osteoarthritis","source":"DrugCentral","snomedId":396275006,"regulator":"FDA","eligibility":"not specified","usPrevalence":null,"globalPrevalence":655000000,"prevalenceMethod":"curated","prevalenceSource":"Arthritis Res Ther, 2023 (PMID:36991481)"},{"name":"Pain","source":"DrugCentral","snomedId":22253000,"regulator":"FDA","eligibility":"adults and children over 3 years old, as recommended by doctor","usPrevalence":51600000,"globalPrevalence":1500000000,"prevalenceMethod":"curated","prevalenceSource":"CDC, 2023"},{"name":"Rheumatoid arthritis","source":"DrugCentral","snomedId":69896004,"regulator":"FDA","usPrevalence":1500000,"globalPrevalence":18000000,"prevalenceMethod":"curated","prevalenceSource":"Lancet Rheumatology, 2023"},{"name":"Sinus headache","source":"DrugCentral","snomedId":4969004,"regulator":"FDA"},{"name":"Toothache","source":"DrugCentral","snomedId":27355003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"isCanonical":true,"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenylbutazone","brandName":"phenylbutazone","genericName":"phenylbutazone","approvalYear":"1980","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[{"url":"https://www.theguardian.com/business/2026/feb/04/wegovy-ozempic-forecast-revenue-share-price-drop","date":"2026-04-07","type":"news","title":"Wegovy and Ozempic maker forecasts sharp drop in revenue for 2026","source":"www.theguardian.com"},{"url":"https://www.mordorintelligence.com/industry-reports/norway-pharmaceutical-market","date":"2026-04-07","type":"news","title":"Norway Pharmaceutical Market Share & Size 2031 Outlook","source":"www.mordorintelligence.com"},{"url":"https://www.drugdiscoverytrends.com/novo-slashes-us-glp-1-prices-by-up-to-70-but-2026-semaglutide-revenue-could-hold-steady-or-even-grow/","date":"2026-04-07","type":"news","title":"Novo cuts GLP-1 prices 70%, but semaglutide revenue could grow ...","source":"www.drugdiscoverytrends.com"},{"url":"https://investor.endo.com/2024-12-09-Endo-Receives-U-S-FDA-Approval-of-Manufacturing-Facility-in-Indore,-India","date":"2026-04-07","type":"news","title":"Endo Receives U.S. FDA Approval of Manufacturing Facility in ...","source":"investor.endo.com"},{"url":"https://www.accessdata.fda.gov/drugsatfda_docs/nda/96/074817ap.pdf","date":"2026-04-07","type":"news","title":"[PDF] 074817 Trade Name - accessdata.fda.gov","source":"www.accessdata.fda.gov"}],"manufacturing":[],"administration":{"route":"Oral","formulation":"Capsule","formulations":[{"form":"CAPSULE","route":"ORAL","productName":"ASPRIN AND EXTENDED-RELEASE DIPYRIDAMOLE"},{"form":"CAPSULE","route":"ORAL","productName":"Ascomp with Codeine"},{"form":"CAPSULE","route":"ORAL","productName":"Aspirin and Dipyridamole Extended Release"},{"form":"CAPSULE","route":"ORAL","productName":"Aspirin and Extended - Release Dipyridamole Capsules, 25 mg / 200 mg"},{"form":"CAPSULE","route":"ORAL","productName":"Aspirin and Extended-Release Dipyridamole"},{"form":"CAPSULE","route":"ORAL","productName":"BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE"},{"form":"CAPSULE","route":"ORAL","productName":"Butalbital, Aspirin, Caffeine and Codeine Phosphate"},{"form":"CAPSULE","route":"ORAL","productName":"Butalbital, Aspirin, Caffeine, and Codeine Phosphate"},{"form":"CAPSULE","route":"ORAL","productName":"Butalbital, Aspirin, and Caffeine"},{"form":"CAPSULE","route":"ORAL","productName":"Butalbital, aspirin, and caffeine"},{"form":"CAPSULE","route":"ORAL","productName":"aspirin-dipyridamole"},{"form":"CAPSULE","route":"ORAL","productName":"butalbital, aspirin, and caffeine"},{"form":"CAPSULE","route":"ORAL","productName":"Aggrenox"},{"form":"CAPSULE","route":"ORAL","productName":"Fiorinal"},{"form":"CAPSULE","route":"ORAL","productName":"Fiorinal with Codeine"}]},"_patentsChecked":true,"crossReferences":{"NUI":"N0000145918","MMSL":"244","NDDF":"001587","UNII":"R16CO5Y76E","VUID":"4017536","CHEBI":"CHEBI:15365","VANDF":"4017536","RXNORM":"1191","UMLSCUI":"C0004057","chemblId":"CHEMBL2429949","ChEMBL_ID":"CHEMBL25","KEGG_DRUG":"D00109","DRUGBANK_ID":"DB00945","PDB_CHEM_ID":" AIN","PUBCHEM_CID":"2244","SNOMEDCT_US":"387458008","IUPHAR_LIGAND_ID":"4139","SECONDARY_CAS_RN":"493-53-8","MESH_DESCRIPTOR_UI":"D001241"},"formularyStatus":[],"_enricherVersion":"v2","chemblMechanisms":[],"developmentCodes":[],"ownershipHistory":[{"period":"1950-","companyName":"Endo Pharms","relationship":"Original Developer"}],"pharmacokinetics":{"source":"DrugCentral","halfLife":"0.26 hours","clearance":"12.0 mL/min/kg","fractionUnbound":"0.68%","volumeOfDistribution":"0.22 L/kg"},"publicationCount":11022,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"M01BA03","allCodes":["A01AD05","B01AC06","B01AC56","C07FX02","C07FX03","C07FX04","C10BX01","C10BX02","C10BX04","C10BX05","C10BX06","C10BX08","C10BX12","M01BA03","N02AJ02","N02AJ07","N02AJ18","N02BA01","N02BA51","N02BA71"]},"biosimilarFilings":[],"originalDeveloper":"Endo Pharms","commercialAnalysis":{"text":"Norgesic, a marketed drug by Endo, works by inhibiting the enzyme nicotinate phosphoribosyltransferase, leading to reduced inflammation and pain. The key indications for Norgesic include arthritic pain, backache, common cold, headache disorder, and influenza-like symptoms. However, the revenue data for Norgesic is not provided in the given sources.\n\nThe competitive landscape for Norgesic is influenced by the Norway pharmaceutical market, which is expected to grow at a 2.28% CAGR from 2026 to 2031, reaching USD 3.58 billion by 2031 [Mordor Intelligence, 2026]. The market is dominated by major players, including Endo, but the exact market share of Norgesic is not disclosed. The recent news of Novo Nordisk's sharp drop in revenue due to lower US drug prices, patent protection issues, and rising competition [The Guardian, 2026] may pose a threat to Norgesic's market position.\n\nKey upcoming catalysts for Norgesic include the patent cliffs and label expansions of its competitors. Novo Nordisk's semaglutide franchise is expected to reach roughly $36 billion in 2026, up from previous estimates [Drug Discovery and Development, 2026]. This growth may lead to increased competition in the market. Additionally, the launch of new GLP-1 drugs and the expansion of existing indications may further impact Norgesic's market share.\n\nIn conclusion, while Norgesic has a established market position, its revenue trajectory and market share are not well-defined. The competitive landscape is influenced by the growth of the Norway pharmaceutical market and the rise of competitors like Novo Nordisk. Key upcoming catalysts, including patent cliffs and label expansions, may impact Norgesic's market position.","model":"llama-3.1-8b (Groq)","sources":[{"url":"https://www.theguardian.com/business/2026/feb/04/wegovy-ozempic-forecast-revenue-share-price-drop","date":"","title":"Wegovy and Ozempic maker forecasts sharp drop in revenue for 2026","source":"www.theguardian.com"},{"url":"https://www.mordorintelligence.com/industry-reports/norway-pharmaceutical-market","date":"","title":"Norway Pharmaceutical Market Share & Size 2031 Outlook","source":"www.mordorintelligence.com"},{"url":"https://www.drugdiscoverytrends.com/novo-slashes-us-glp-1-prices-by-up-to-70-but-2026-semaglutide-revenue-could-hold-steady-or-even-grow/","date":"","title":"Novo cuts GLP-1 prices 70%, but semaglutide revenue could grow ...","source":"www.drugdiscoverytrends.com"}],"disclaimer":"AI-generated analysis based on public sources. Verify with primary sources for investment decisions.","generatedDate":"2026-04-07"},"recentPublications":[{"pmid":"41988162","title":"Acetylsalicylic acid versus clopidogrel in cardiovascular prevention: Does the classic still outperform the contemporary?","authors":"Sousa IJO, de Melo Nogueira K","journal":"EXCLI J","pubDate":"2026"},{"pmid":"41973014","title":"Evaluating the Effect of Acetylsalicylic Acid in Turkey Poults Experimentally Infected with Coccidia.","authors":"Gore A, Chan PM, Yeatts JL, Baynes RE, Kulkarni RR","journal":"Avian Dis","pubDate":"2026 Apr"},{"pmid":"41968414","title":"Acetylsalicylic acid challenge in children with suspected NSAID hypersensitivity: A single-centre experience.","authors":"Jimenez-Freites M, Machinena-Spera A, Lozano-Blasco J, Alvaro-Lozano M, Jimenez-Feijo R","journal":"Pediatr Allergy Immunol","pubDate":"2026 Apr"},{"pmid":"41967914","title":"Letter to \"Management of Pregnancies With a History of Venous Thromboembolism: Low-Dose Low-Molecular-Weight Heparin and Low-Dose Acetylsalicylic Acid Prophylaxis\".","authors":"Xu J, Yang D","journal":"J Obstet Gynaecol Res","pubDate":"2026 Apr"},{"pmid":"41838129","title":"Attenuation of imidacloprid deleterious effect on hepatic and neural tissues via acetylsalicylic acid: targeting HMGB1/caspase-3 axis and inflammatory pathway.","authors":"Ragab AM, Mohamed AA, Abdo W, Hashem HM, Elmadawy MA","journal":"Naunyn Schmiedebergs Arch Pharmacol","pubDate":"2026 Mar 16"},{"pmid":"41791655","title":"Acetylsalicylic acid improves outcome after acute myocardial infarction by reducing thromboinflammation.","authors":"Helten C, Benkhoff M, Mourikis P, Metzen D, Barcik M","journal":"J Thromb Haemost","pubDate":"2026 Mar 4"},{"pmid":"41696274","title":"Structural, Electronic, and Optical Properties of Monoclinic Pharmaceutical Crystals: A DFT Study of Salicylic Acid, Acetylsalicylic Acid, Acetaminophen, and Ibuprofen.","authors":"Ferreira LL, Alves MS, P Oliveira ME, Freire VN, Silva BP","journal":"ACS Omega","pubDate":"2026 Feb 10"},{"pmid":"41686719","title":"The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.","authors":"Engert LC, Dang R, Chatterton B, Daniel S, Mullington JM","journal":"Neuroimmunomodulation","pubDate":"2026"},{"pmid":"41649596","title":"Unveiling the anti-glycation properties of acetylsalicylic acid: targeted inhibition of albumin glycation.","authors":"Tupe R, Durge A, Jagdale A","journal":"Amino Acids","pubDate":"2026 Feb 6"},{"pmid":"41649541","title":"Correction to: Associations of sphingosine‑1‑phosphate with soluble P‑selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment.","authors":"Gloyer NO, Moritz E, Schwieren L, Meyer U, Thomalla G","journal":"Naunyn Schmiedebergs Arch Pharmacol","pubDate":"2026 Feb"}],"rxnormFormulations":[{"tty":"BPCK","name":"{100 (acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Excedrin]) / 24 (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action]) } Pack [Excedrin PM Triple Action Caplets and Excedrin Extra Strength Pain Reliever]","rxcui":"2047428","synonym":"Excedrin PM Triple Action Caplets and Excedrin Extra Strength Pain Reliever Kit"},{"tty":"GPCK","name":"{1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 (aspirin 500 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) } Pack","rxcui":"1730187","synonym":"1 daytime (aspirin 325 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 nighttime (aspirin 500 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) Pack"},{"tty":"GPCK","name":"{100 (acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet) / 24 (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet) } Pack","rxcui":"2047427","synonym":"100 daytime (acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet) / 24 nighttime (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet) Kit"},{"tty":"GPCK","name":"{1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) } Pack","rxcui":"2565492","synonym":"1 daytime (aspirin 325 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 nighttime (aspirin 325 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) Pack"},{"tty":"GPCK","name":"{1 (aspirin 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) } Pack","rxcui":"2664074","synonym":"1 daytime (aspirin 325 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 nighttime (aspirin 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) Pack"},{"tty":"GPCK","name":"{30 (aspirin 325 MG Oral Tablet) / 30 (pravastatin sodium 80 MG Oral Tablet) } Pack","rxcui":"904664","synonym":""},{"tty":"GPCK","name":"{30 (aspirin 81 MG Oral Tablet) / 30 (pravastatin sodium 40 MG Oral Tablet) } Pack","rxcui":"904668","synonym":""},{"tty":"SBD","name":"acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Pamprin Max Formula]","rxcui":"1052416","synonym":"APAP 250 MG / ASA 250 MG / Caffeine 65 MG Oral Tablet [Pamprin Max Formula]"},{"tty":"SBD","name":"aspirin 81 MG Delayed Release Oral Tablet [Miniprin]","rxcui":"1052678","synonym":"Miniprin 81 MG Delayed Release Oral Tablet"},{"tty":"SBD","name":"aspirin 845 MG / caffeine 65 MG Oral Powder [Stanback Headache Powder Reformulated Jan 2011]","rxcui":"1053327","synonym":"ASA 845 MG / Caffeine 65 MG Oral Powder [Stanback Headache Powder Reformulated Jan 2011]"},{"tty":"SBD","name":"acetaminophen 194 MG / aspirin 227 MG / caffeine 33 MG Oral Tablet [Vanquish]","rxcui":"1101754","synonym":"APAP 194 MG / ASA 227 MG / Caffeine 33 MG Oral Tablet [Vanquish]"},{"tty":"SBD","name":"aspirin 81 MG Delayed Release Oral Tablet [Ecotrin]","rxcui":"1189781","synonym":"Ecotrin 81 MG Delayed Release Oral Tablet"},{"tty":"SBD","name":"aspirin 1000 MG / caffeine 65 MG Oral Powder [BC Arthritis]","rxcui":"1247397","synonym":"ASA 1000 MG / Caffeine 65 MG Oral Powder [BC Arthritis]"},{"tty":"SBD","name":"aspirin 845 MG / caffeine 65 MG Oral Powder [BC Original Formula]","rxcui":"1247402","synonym":"BC Pain Relief (ASA 845 MG / caffeine 65 MG) Oral Powder"},{"tty":"SBD","name":"acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Arthriten Inflammatory Pain]","rxcui":"1303159","synonym":"APAP 250 MG / ASA 250 MG / Caffeine 65 MG Oral Tablet [Arthriten Inflammatory Pain]"},{"tty":"SBD","name":"acetaminophen 110 MG / aspirin 162 MG / caffeine 32.4 MG / salicylamide 152 MG Oral Tablet [Exaprin]","rxcui":"1358853","synonym":"APAP 110 MG / ASA 162 MG / Caffeine 32.4 MG / salicylamide 152 MG Oral Tablet [Exaprin]"},{"tty":"SBD","name":"acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Backaid IPF]","rxcui":"1361402","synonym":"APAP 250 MG / ASA 250 MG / Caffeine 65 MG Oral Tablet [Backaid IPF]"},{"tty":"SBD","name":"aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer]","rxcui":"1536680","synonym":"ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer]"},{"tty":"SBD","name":"aspirin 500 MG / citric acid 1000 MG / sodium bicarbonate 1985 MG Effervescent Oral Tablet [Alka-Seltzer]","rxcui":"1536835","synonym":"ASA 500 MG / Citric Acid 1000 MG / NaHCO3 1985 MG Effervescent Oral Tablet [Alka-Seltzer]"},{"tty":"SBD","name":"aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever]","rxcui":"1537012","synonym":"ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever]"},{"tty":"SBD","name":"acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action]","rxcui":"1593116","synonym":"APAP 250 MG / ASA 250 MG / Diphenhydramine Citrate 38 MG Oral Tablet [Excedrin PM Triple Action]"},{"tty":"SBD","name":"aspirin 81 MG Delayed Release Oral Tablet [Aspi-Cor]","rxcui":"1600991","synonym":"Aspi-Cor 81 MG Delayed Release Oral Tablet"},{"tty":"SBD","name":"24 HR aspirin 162.5 MG Extended Release Oral Capsule [Durlaza]","rxcui":"1665362","synonym":"Durlaza 162.5 MG 24HR Extended Release Oral Capsule"},{"tty":"SBD","name":"aspirin 325 MG / omeprazole 40 MG Delayed Release Oral Tablet [Yosprala]","rxcui":"1811916","synonym":"ASA 325 MG / Omeprazole 40 MG Delayed Release Oral Tablet [Yosprala]"},{"tty":"SBD","name":"aspirin 81 MG / omeprazole 40 MG Delayed Release Oral Tablet [Yosprala]","rxcui":"1811918","synonym":"ASA 81 MG / Omeprazole 40 MG Delayed Release Oral Tablet [Yosprala]"},{"tty":"SBD","name":"aspirin 500 MG / citric acid 1000 MG / sodium bicarbonate 1985 MG Granules for Oral Solution [Alka-Seltzer]","rxcui":"1872088","synonym":"ASA 500 MG / Citric Acid 1000 MG / NaHCO3 1985 MG Granules for Oral Solution [Alka-Seltzer]"},{"tty":"SBD","name":"aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1700 MG Effervescent Oral Tablet [Alka-Seltzer]","rxcui":"1925790","synonym":"ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1700 MG Effervescent Oral Tablet [Alka-Seltzer]"},{"tty":"SBD","name":"acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Excedrin]","rxcui":"209468","synonym":"APAP 250 MG / ASA 250 MG / Caffeine 65 MG Oral Tablet [Excedrin]"},{"tty":"SBD","name":"aspirin 325 MG / meprobamate 200 MG Oral Tablet [Equagesic]","rxcui":"209823","synonym":"ASA 325 MG / Meprobamate 200 MG Oral Tablet [Equagesic]"},{"tty":"SBD","name":"acetaminophen 115 MG / aspirin 210 MG / caffeine 16 MG / salicylamide 65 MG Oral Tablet [Saleto]","rxcui":"210864","synonym":"APAP 115 MG / ASA 210 MG / Caffeine 16 MG / salicylamide 65 MG Oral Tablet [Saleto]"},{"tty":"SBD","name":"aspirin 400 MG / caffeine 32 MG Oral Tablet [Anacin]","rxcui":"211292","synonym":"ASA 400 MG / Caffeine 32 MG Oral Tablet [Anacin]"},{"tty":"SBD","name":"aspirin 400 MG / caffeine 32 MG Oral Tablet [P-A-C Analgesic]","rxcui":"211297","synonym":"ASA 400 MG / Caffeine 32 MG Oral Tablet [P-A-C Analgesic]"},{"tty":"SBD","name":"aspirin 81 MG Chewable Tablet [St. Joseph Aspirin]","rxcui":"211832","synonym":"St. Joseph Aspirin 81 MG Chewable Tablet"},{"tty":"SBD","name":"aspirin 325 MG Oral Tablet [Bayer Aspirin]","rxcui":"211874","synonym":"Bayer Aspirin 325 MG Oral Tablet"},{"tty":"SBD","name":"aspirin 325 MG Oral Tablet [Norwich Aspirin]","rxcui":"211881","synonym":"Norwich Aspirin 325 MG Oral Tablet"},{"tty":"SBD","name":"aspirin 500 MG Oral Tablet [Bayer Aspirin]","rxcui":"211887","synonym":"Bayer Aspirin 500 MG Oral Tablet"},{"tty":"SBD","name":"aspirin 500 MG Oral Tablet [Norwich Aspirin]","rxcui":"211891","synonym":"Norwich Aspirin 500 MG Oral Tablet"},{"tty":"SBD","name":"aspirin 325 MG Delayed Release Oral Tablet [Ecotrin]","rxcui":"212086","synonym":"Ecotrin 325 MG Delayed Release Oral Tablet"},{"tty":"SBD","name":"aspirin 325 MG Oral Capsule [Vazalore]","rxcui":"2563428","synonym":"Vazalore 325 MG Oral Capsule"},{"tty":"SBD","name":"aspirin 81 MG Oral Capsule [Vazalore]","rxcui":"2563431","synonym":"Vazalore 81 MG Oral Capsule"},{"tty":"SBD","name":"aspirin 325 MG Oral Tablet [Bufferin]","rxcui":"260847","synonym":"Bufferin 325 MG Oral Tablet"},{"tty":"SBD","name":"acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus]","rxcui":"2723568","synonym":"APAP 250 MG / ASA 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus]"},{"tty":"SBD","name":"aspirin 325 MG Delayed Release Oral Tablet [Bayer Aspirin]","rxcui":"387090","synonym":"Bayer Aspirin 325 MG Delayed Release Oral Tablet"},{"tty":"SBD","name":"aspirin 500 MG / caffeine 32 MG Oral Tablet [Anacin]","rxcui":"608696","synonym":"ASA 500 MG / Caffeine 32 MG Oral Tablet [Anacin]"},{"tty":"SBD","name":"acetaminophen 250 MG / aspirin 250 MG Oral Tablet [Excedrin Back & Body]","rxcui":"723530","synonym":"APAP 250 MG / ASA 250 MG Oral Tablet [Excedrin Back & Body]"},{"tty":"SBD","name":"acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Anacin Advanced Headache Formula]","rxcui":"723533","synonym":"APAP 250 MG / ASA 250 MG / Caffeine 65 MG Oral Tablet [Anacin Advanced Headache Formula]"},{"tty":"SBD","name":"aspirin 81 MG Oral Tablet [Anacin Aspirin Regimen]","rxcui":"724444","synonym":"Anacin Aspirin Regimen 81 MG Oral Tablet"},{"tty":"SBD","name":"aspirin 81 MG Delayed Release Oral Tablet [St. Joseph Aspirin]","rxcui":"749795","synonym":"St. Joseph Aspirin 81 MG Delayed Release Oral Tablet"},{"tty":"SBD","name":"aspirin 81 MG Delayed Release Oral Tablet [Bayer Aspirin]","rxcui":"794229","synonym":"Bayer Aspirin 81 MG Delayed Release Oral Tablet"},{"tty":"SBD","name":"aspirin 81 MG Chewable Tablet [Bayer Aspirin]","rxcui":"825180","synonym":"Bayer Aspirin 81 MG Chewable Tablet"},{"tty":"SBD","name":"aspirin 500 MG Oral Tablet [Bufferin]","rxcui":"848166","synonym":"Bufferin 500 MG Oral Tablet"},{"tty":"SBD","name":"aspirin 228 MG Chewing Gum [Aspergum]","rxcui":"853501","synonym":"Aspergum 227.5 MG Chewing Gum"},{"tty":"SBD","name":"aspirin 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral Capsule [Ascomp]","rxcui":"994239","synonym":"ASA 325 MG / butalbital 50 MG / Caffeine 40 MG / Codeine Phosphate 30 MG Oral Capsule [Ascomp]"},{"tty":"SBD","name":"aspirin 385 MG / caffeine 30 MG / orphenadrine citrate 25 MG Oral Tablet [Norgesic]","rxcui":"994530","synonym":"Norgesic 25/385/30 (orphenadrine / aspirin / caffeine) Oral Tablet"},{"tty":"SBD","name":"aspirin 770 MG / caffeine 60 MG / orphenadrine citrate 50 MG Oral Tablet [Norgesic]","rxcui":"994537","synonym":"Norgesic forte 50/770/60 (orphenadrine / aspirin / caffeine) Oral Tablet"},{"tty":"SBD","name":"aspirin 770 MG / caffeine 60 MG / orphenadrine citrate 50 MG Oral Tablet [Orphengesic]","rxcui":"994539","synonym":"ASA 770 MG / Caffeine 60 MG / Orphenadrine Citrate 50 MG Oral Tablet [Orphengesic]"},{"tty":"SCD","name":"aspirin 150 MG Rectal Suppository","rxcui":"103863","synonym":"ASA 150 MG Rectal Suppository"},{"tty":"SCD","name":"aspirin 75 MG Delayed Release Oral Tablet","rxcui":"103954","synonym":"ASA 75 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 75 MG Oral Tablet","rxcui":"104474","synonym":"ASA 75 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 75 MG Disintegrating Oral Tablet","rxcui":"104475","synonym":"ASA 75 MG Disintegrating Oral Tablet"},{"tty":"SCD","name":"aspirin 300 MG Delayed Release Oral Tablet","rxcui":"104899","synonym":"ASA 300 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / glycine 133 MG Disintegrating Oral Tablet","rxcui":"106809","synonym":"ASA 500 MG / Glycine 133 MG Disintegrating Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / diphenhydramine hydrochloride 25 MG Oral Tablet","rxcui":"1092398","synonym":"ASA 500 MG / Diphenhydramine Hydrochloride 25 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 356.4 MG / caffeine 30 MG / dihydrocodeine bitartrate 16 MG Oral Capsule","rxcui":"1234872","synonym":"ASA 356.4 MG / caffeine 30 MG / dihydrocodeine bitartrate 16 MG Oral Capsule"},{"tty":"SCD","name":"aspirin 500 MG / diphenhydramine citrate 38.3 MG Oral Tablet","rxcui":"1250907","synonym":"ASA 500 MG / Diphenhydramine Citrate 38.3 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / diphenhydramine citrate 38 MG Oral Tablet","rxcui":"1291868","synonym":"ASA 325 MG / Diphenhydramine Citrate 38 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 120 MG Chewable Tablet","rxcui":"1433630","synonym":"ASA 120 MG Chewable Tablet"},{"tty":"SCD","name":"aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1700 MG Effervescent Oral Tablet","rxcui":"1536467","synonym":"ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1700 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet","rxcui":"1536498","synonym":"ASA 325 MG / Dextromethorphan Hydrobromide 10 MG / Phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet","rxcui":"1536503","synonym":"ASA 500 MG / Dextromethorphan Hydrobromide 10 MG / doxylamine succinate 6.25 MG / Phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet","rxcui":"1536675","synonym":"ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet","rxcui":"1536815","synonym":"ASA 500 MG / Caffeine 65 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / citric acid 1000 MG / sodium bicarbonate 1985 MG Effervescent Oral Tablet","rxcui":"1536833","synonym":"ASA 500 MG / Citric Acid 1000 MG / NaHCO3 1985 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / chlorpheniramine maleate 2 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet","rxcui":"1536840","synonym":"ASA 325 MG / Chlorpheniramine Maleate 2 MG / Phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / chlorpheniramine maleate 2 MG / phenylephrine bitartrate 8 MG Effervescent Oral Tablet","rxcui":"1536993","synonym":"ASA 500 MG / Chlorpheniramine Maleate 2 MG / Phenylephrine bitartrate 8 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / caffeine 60 MG Effervescent Oral Tablet","rxcui":"1537019","synonym":"ASA 500 MG / Caffeine 60 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet","rxcui":"1537029","synonym":"ASA 325 MG / Chlorpheniramine Maleate 2 MG / Dextromethorphan Hydrobromide 10 MG / Phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet","rxcui":"1593110","synonym":"APAP 250 MG / ASA 250 MG / Diphenhydramine Citrate 38 MG Oral Tablet"},{"tty":"SCD","name":"24 HR aspirin 162.5 MG Extended Release Oral Capsule","rxcui":"1665356","synonym":"24 HR ASA 162.5 MG Extended Release Oral Capsule"},{"tty":"SCD","name":"aspirin 81 MG / calcium carbonate 777 MG Oral Tablet","rxcui":"1722689","synonym":"ASA 81 MG / Calcium Carbonate 777 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 81 MG / omeprazole 40 MG Delayed Release Oral Tablet","rxcui":"1811631","synonym":"ASA 81 MG / Omeprazole 40 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / omeprazole 40 MG Delayed Release Oral Tablet","rxcui":"1811632","synonym":"ASA 325 MG / Omeprazole 40 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / citric acid 1000 MG / sodium bicarbonate 1985 MG Granules for Oral Solution","rxcui":"1872085","synonym":"ASA 500 MG / Citric Acid 1000 MG / NaHCO3 1985 MG Granules for Oral Solution"},{"tty":"SCD","name":"aspirin 325 MG / carisoprodol 200 MG Oral Tablet","rxcui":"197447","synonym":"ASA 325 MG / Carisoprodol 200 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / meprobamate 200 MG Oral Tablet","rxcui":"197930","synonym":"ASA 325 MG / Meprobamate 200 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / methocarbamol 400 MG Oral Tablet","rxcui":"197945","synonym":"ASA 325 MG / Methocarbamol 400 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 120 MG Rectal Suppository","rxcui":"198461","synonym":"ASA 120 MG Rectal Suppository"},{"tty":"SCD","name":"aspirin 200 MG Rectal Suppository","rxcui":"198463","synonym":"ASA 200 MG Rectal Suppository"},{"tty":"SCD","name":"aspirin 300 MG Rectal Suppository","rxcui":"198464","synonym":"ASA 300 MG Rectal Suppository"},{"tty":"SCD","name":"aspirin 325 MG Oral Capsule","rxcui":"198466","synonym":"ASA 325 MG Oral Capsule"},{"tty":"SCD","name":"aspirin 325 MG Delayed Release Oral Tablet","rxcui":"198467","synonym":"ASA 325 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG Oral Tablet","rxcui":"198471","synonym":"ASA 500 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 600 MG Rectal Suppository","rxcui":"198473","synonym":"ASA 600 MG Rectal Suppository"},{"tty":"SCD","name":"aspirin 650 MG Oral Tablet","rxcui":"198475","synonym":"ASA 650 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 162 MG Delayed Release Oral Tablet","rxcui":"198477","synonym":"ASA 162 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 400 MG / caffeine 32 MG Oral Tablet","rxcui":"198479","synonym":"ASA 400 MG / Caffeine 32 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / caffeine 32 MG Oral Tablet","rxcui":"198480","synonym":"ASA 500 MG / Caffeine 32 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 300 MG Oral Tablet","rxcui":"199281","synonym":"ASA 300 MG Oral Tablet"},{"tty":"SCD","name":"acetaminophen 160 MG / aspirin 230 MG / caffeine 33 MG Oral Tablet","rxcui":"205251","synonym":"APAP 160 MG / ASA 230 MG / Caffeine 33 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG Oral Tablet","rxcui":"212033","synonym":"ASA 325 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 1000 MG / caffeine 150 MG Oral Powder","rxcui":"2267026","synonym":"ASA 1000 MG / Caffeine 150 MG Oral Powder"},{"tty":"SCD","name":"acetaminophen 500 MG / aspirin 500 MG / caffeine 65 MG Oral Powder","rxcui":"2360605","synonym":"APAP 500 MG / ASA 500 MG / caffeine 65 MG Oral Powder"},{"tty":"SCD","name":"aspirin 325 MG / butalbital 50 MG / caffeine 40 MG Oral Capsule","rxcui":"238134","synonym":"ASA 325 MG / butalbital 50 MG / Caffeine 40 MG Oral Capsule"},{"tty":"SCD","name":"aspirin 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet","rxcui":"238135","synonym":"ASA 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 81 MG Oral Tablet","rxcui":"243670","synonym":"ASA 81 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 421 MG / caffeine 32 MG Oral Tablet","rxcui":"243685","synonym":"ASA 421 MG / Caffeine 32 MG Oral Tablet"},{"tty":"SCD","name":"acetaminophen 194 MG / aspirin 227 MG / caffeine 33 MG Oral Tablet","rxcui":"243694","synonym":"APAP 194 MG / ASA 227 MG / caffeine 33 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 100 MG Oral Tablet","rxcui":"246461","synonym":"ASA 100 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 650 MG Oral Powder","rxcui":"247137","synonym":"ASA 650 MG Oral Powder"},{"tty":"SCD","name":"aspirin 325 MG / caffeine 15 MG Oral Tablet","rxcui":"247892","synonym":"ASA 325 MG / Caffeine 15 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 81 MG Oral Capsule","rxcui":"252857","synonym":"ASA 81 MG Oral Capsule"},{"tty":"SCD","name":"aspirin 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet","rxcui":"2565491","synonym":"ASA 325 MG / Dextromethorphan Hydrobromide 10 MG / doxylamine succinate 6.25 MG / Phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG / butalbital 50 MG / caffeine 40 MG Oral Capsule","rxcui":"2583731","synonym":"ASA 500 MG / butalbital 50 MG / caffeine 40 MG Oral Capsule"},{"tty":"SCD","name":"12 HR aspirin 25 MG / dipyridamole 200 MG Extended Release Oral Capsule","rxcui":"259081","synonym":"12 HR ASA 25 MG / Dipyridamole 200 MG Extended Release Oral Capsule"},{"tty":"SCD","name":"aspirin 325 MG Effervescent Oral Tablet","rxcui":"2606079","synonym":"ASA 325 MG Effervescent Oral Tablet"},{"tty":"SCD","name":"aspirin 650 MG / caffeine 65 MG Oral Powder","rxcui":"2626726","synonym":"ASA 650 MG / caffeine 65 MG Oral Powder"},{"tty":"SCD","name":"acetaminophen 500 MG / aspirin 500 MG / caffeine 130 MG Oral Powder","rxcui":"2734143","synonym":"APAP 500 MG / ASA 500 MG / caffeine 130 MG Oral Powder"},{"tty":"SCD","name":"acetaminophen 115 MG / aspirin 210 MG / caffeine 16 MG / salicylamide 65 MG Oral Tablet","rxcui":"308278","synonym":"APAP 115 MG / ASA 210 MG / caffeine 16 MG / salicylamide 65 MG Oral Tablet"},{"tty":"SCD","name":"acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet","rxcui":"308297","synonym":"APAP 250 MG / ASA 250 MG / caffeine 65 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / caffeine 16 MG / salicylamide 95 MG Oral Tablet","rxcui":"308363","synonym":"ASA 325 MG / Caffeine 16 MG / salicylamide 95 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 165 MG Delayed Release Oral Tablet","rxcui":"308403","synonym":"ASA 165 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 500 MG Delayed Release Oral Tablet","rxcui":"308409","synonym":"ASA 500 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 650 MG Delayed Release Oral Tablet","rxcui":"308411","synonym":"ASA 650 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 81 MG Delayed Release Oral Tablet","rxcui":"308416","synonym":"ASA 81 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 975 MG Delayed Release Oral Tablet","rxcui":"308417","synonym":"ASA 975 MG Delayed Release Oral Tablet"},{"tty":"SCD","name":"aspirin 81 MG Chewable Tablet","rxcui":"318272","synonym":"ASA 81 MG Chewable Tablet"},{"tty":"SCD","name":"aspirin 60 MG Chewable Tablet","rxcui":"333834","synonym":"ASA 60 MG Chewable Tablet"},{"tty":"SCD","name":"aspirin 800 MG Oral Tablet","rxcui":"349516","synonym":"ASA 800 MG Oral Tablet"},{"tty":"SCD","name":"acetaminophen 110 MG / aspirin 162 MG / caffeine 32.4 MG / salicylamide 152 MG Oral Tablet","rxcui":"359221","synonym":"APAP 110 MG / ASA 162 MG / Caffeine 32.4 MG / salicylamide 152 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 975 MG Oral Tablet","rxcui":"391930","synonym":"ASA 975 MG Oral Tablet"},{"tty":"SCD","name":"acetaminophen 250 MG / aspirin 250 MG Oral Tablet","rxcui":"432638","synonym":"APAP 250 MG / ASA 250 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 300 MG Chewable Tablet","rxcui":"433353","synonym":"ASA 300 MG Chewable Tablet"},{"tty":"SCD","name":"aspirin 650 MG / caffeine 33.3 MG / salicylamide 195 MG Oral Powder","rxcui":"605252","synonym":"ASA 650 MG / Caffeine 33.3 MG / salicylamide 195 MG Oral Powder"},{"tty":"SCD","name":"aspirin 325 MG / oxycodone hydrochloride 4.5 MG / oxycodone terephthalate 0.38 MG Oral Tablet","rxcui":"637540","synonym":"ASA 325 MG / Oxycodone Hydrochloride 4.5 MG / oxycodone terephthalate 0.38 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 1.5 MG/ML Oral Solution","rxcui":"685589","synonym":"ASA 1.5 MG/ML Oral Solution"},{"tty":"SCD","name":"aspirin 2.5 MG/ML Oral Solution","rxcui":"688214","synonym":"ASA 2.5 MG/ML Oral Solution"},{"tty":"SCD","name":"acetaminophen 325 MG / aspirin 500 MG / caffeine 65 MG Oral Powder","rxcui":"692836","synonym":"APAP 325 MG / ASA 500 MG / Caffeine 65 MG Oral Powder"},{"tty":"SCD","name":"aspirin 500 MG / caffeine 32.5 MG Oral Tablet","rxcui":"702316","synonym":"ASA 500 MG / Caffeine 32.5 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / oxycodone hydrochloride 2.25 MG / oxycodone terephthalate 0.19 MG Oral Tablet","rxcui":"724614","synonym":"ASA 325 MG / Oxycodone Hydrochloride 2.25 MG / oxycodone terephthalate 0.19 MG Oral Tablet"},{"tty":"SCD","name":"acetaminophen 325 MG / aspirin 500 MG Oral Powder","rxcui":"763111","synonym":"APAP 325 MG / ASA 500 MG Oral Powder"},{"tty":"SCD","name":"acetaminophen 260 MG / aspirin 520 MG / caffeine 32.5 MG Oral Powder","rxcui":"763116","synonym":"APAP 260 MG / ASA 520 MG / Caffeine 32.5 MG Oral Powder"},{"tty":"SCD","name":"aspirin 650 MG / caffeine 32 MG / salicylamide 200 MG Oral Powder","rxcui":"797050","synonym":"ASA 650 MG / Caffeine 32 MG / salicylamide 200 MG Oral Powder"},{"tty":"SCD","name":"aspirin 500 MG / caffeine 65 MG Oral Tablet","rxcui":"806446","synonym":"ASA 500 MG / Caffeine 65 MG Oral Tablet"},{"tty":"SCD","name":"acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Capsule","rxcui":"827318","synonym":"APAP 250 MG / ASA 250 MG / Caffeine 65 MG Oral Capsule"},{"tty":"SCD","name":"aspirin 389 MG / caffeine 32.4 MG / propoxyphene hydrochloride 32 MG Oral Capsule","rxcui":"828585","synonym":"ASA 389 MG / Caffeine 32.4 MG / Propoxyphene Hydrochloride 32 MG Oral Capsule"},{"tty":"SCD","name":"aspirin 389 MG / caffeine 32.4 MG / propoxyphene hydrochloride 65 MG Oral Capsule","rxcui":"828594","synonym":"ASA 389 MG / Caffeine 32.4 MG / Propoxyphene Hydrochloride 65 MG Oral Capsule"},{"tty":"SCD","name":"aspirin 325 MG / oxycodone hydrochloride 4.84 MG Oral Tablet","rxcui":"848768","synonym":"ASA 325 MG / oxycodone hydrochloride 4.84 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 228 MG Chewing Gum","rxcui":"853499","synonym":"ASA 228 MG Chewing Gum"},{"tty":"SCD","name":"aspirin 500 MG / hydrocodone bitartrate 5 MG Oral Tablet","rxcui":"857121","synonym":"ASA 500 MG / Hydrocodone Bitartrate 5 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 360 MG / caffeine 75 MG / magnesium carbonate 100 MG / magnesium salicylate 60 MG Oral Tablet","rxcui":"863184","synonym":"ASA 360 MG / caffeine 75 MG / magnesium carbonate 100 MG / magnesium salicylate 60 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 410 MG / caffeine 60 MG / salicylamide 30 MG Oral Tablet","rxcui":"863186","synonym":"ASA 410 MG / Caffeine 60 MG / salicylamide 30 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 15600 MG Oral Tablet","rxcui":"891134","synonym":"ASA 15600 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 31200 MG Oral Tablet","rxcui":"891136","synonym":"ASA 31200 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 3900 MG Oral Tablet","rxcui":"892160","synonym":"aspirin 60 Grains"},{"tty":"SCD","name":"aspirin 742 MG / caffeine 38 MG / salicylamide 222 MG Oral Powder","rxcui":"896884","synonym":"ASA 742 MG / Caffeine 38 MG / salicylamide 222 MG Oral Powder"},{"tty":"SCD","name":"aspirin 1 MG/MG Oral Powder","rxcui":"900470","synonym":"ASA 1 MG/MG Oral Powder"},{"tty":"SCD","name":"aspirin 850 MG / caffeine 65 MG Oral Powder","rxcui":"900528","synonym":"ASA 850 MG / Caffeine 65 MG Oral Powder"},{"tty":"SCD","name":"aspirin 325 MG / carisoprodol 200 MG / codeine phosphate 16 MG Oral Tablet","rxcui":"994226","synonym":"ASA 325 MG / carisoprodol 200 MG / codeine phosphate 16 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral Capsule","rxcui":"994237","synonym":"ASA 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral Capsule"},{"tty":"SCD","name":"aspirin 1000 MG / caffeine 65 MG Oral Powder","rxcui":"994430","synonym":"ASA 1000 MG / Caffeine 65 MG Oral Powder"},{"tty":"SCD","name":"aspirin 845 MG / caffeine 65 MG Oral Powder","rxcui":"994435","synonym":"ASA 845 MG / Caffeine 65 MG Oral Powder"},{"tty":"SCD","name":"aspirin 385 MG / caffeine 30 MG / orphenadrine citrate 25 MG Oral Tablet","rxcui":"994528","synonym":"ASA 385 MG / Caffeine 30 MG / Orphenadrine Citrate 25 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 770 MG / caffeine 60 MG / orphenadrine citrate 50 MG Oral Tablet","rxcui":"994535","synonym":"ASA 770 MG / caffeine 60 MG / orphenadrine citrate 50 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 428 MG / caffeine 30 MG / orphenadrine citrate 25 MG Oral Tablet","rxcui":"994810","synonym":"ASA 428 MG / Caffeine 30 MG / Orphenadrine Citrate 25 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 856 MG / caffeine 60 MG / orphenadrine citrate 50 MG Oral Tablet","rxcui":"994811","synonym":"ASA 856 MG / Caffeine 60 MG / Orphenadrine Citrate 50 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 300 MG / codeine phosphate 8 MG Oral Tablet","rxcui":"996988","synonym":"ASA 300 MG / Codeine Phosphate 8 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / codeine phosphate 30 MG Oral Tablet","rxcui":"996991","synonym":"ASA 325 MG / Codeine Phosphate 30 MG Oral Tablet"},{"tty":"SCD","name":"aspirin 325 MG / codeine phosphate 60 MG Oral Tablet","rxcui":"996994","synonym":"ASA 325 MG / Codeine Phosphate 60 MG Oral Tablet"}],"participantFlowData":[],"companionDiagnostics":[],"structuredTrialResults":[{"hr":"","nctId":"NCT02521285","phase":"PHASE2","pValue":"0.343","ciLower":"","ciUpper":"","endpoint":"Difference in the Change of CDX2 mRNA Levels in Esophageal Mucosa Between Participants Taking Aspirin and Placebo at 12 Months (Location A)","enrollment":21}],"genericManufacturerList":[],"status":"active","companyName":"Endo","companyId":"endo","modality":"Small molecule","firstApprovalDate":"1950","enrichmentLevel":5,"visitCount":16,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"patentsNormalised":[{"patent_number":"8206741","territory":"US","patent_type":null,"expiry_date":"2023-02-28T00:00:00.000Z","status":"active","paragraph_iv_filed":false},{"patent_number":"6926907","territory":"US","patent_type":null,"expiry_date":"2023-02-28T00:00:00.000Z","status":"active","paragraph_iv_filed":false},{"patent_number":"9226892","territory":"US","patent_type":null,"expiry_date":"2032-09-29T00:00:00.000Z","status":"active","paragraph_iv_filed":false},{"patent_number":"9216150","territory":"US","patent_type":null,"expiry_date":"2032-09-29T00:00:00.000Z","status":"active","paragraph_iv_filed":false},{"patent_number":"10646431","territory":"US","patent_type":null,"expiry_date":"2032-09-29T00:00:00.000Z","status":"active","paragraph_iv_filed":false},{"patent_number":"10786444","territory":"US","patent_type":null,"expiry_date":"2032-09-29T00:00:00.000Z","status":"active","paragraph_iv_filed":false},{"patent_number":"9987231","territory":"US","patent_type":null,"expiry_date":"2033-01-02T00:00:00.000Z","status":"active","paragraph_iv_filed":false},{"patent_number":"9539214","territory":"US","patent_type":null,"expiry_date":"2033-03-13T00:00:00.000Z","status":"active","paragraph_iv_filed":false}],"trialStats":{"total":66,"withResults":6},"validation":{"fieldsValidated":6,"lastValidatedAt":"2026-04-20T08:25:14.368402+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}