{"id":"acetyldihydrocodeine","rwe":[],"tags":[{"label":"acetyldihydrocodeine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R05DA12","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"acetylcodone","offLabel":[],"synonyms":["acetyldihydrocodeine","acetylcodone","dihydrocodeine 6-acetate","dihydrothebacone","O-Acetyldihydrocodeine"],"timeline":[],"brandName":"Acetylcodone","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"acetyldihydrocodeine","explanation":"Imagine your brain has special locks that control how you feel pain. Acetyldihydrocodeine is a key that fits into these locks, changing the way the locks work and reducing the sensation of pain. This helps to relieve pain and discomfort.","oneSentence":"Acetyldihydrocodeine works by binding to opioid receptors in the brain, altering the perception of pain.","technicalDetail":"Acetyldihydrocodeine exerts its effects by binding to mu-opioid receptors, kappa-opioid receptors, and delta-opioid receptors, which are involved in the transmission of pain signals in the central nervous system."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Acetyldihydrocodeine","title":"Acetyldihydrocodeine","extract":"Acetyldihydrocodeine is an opiate derivative discovered in Germany in 1914 and was used as a cough suppressant and analgesic. It is not commonly used, but has activity similar to other opiates. Acetyldihydrocodeine is a very close relative derivative of thebacon, where only the 6-7 bond is unsaturated. Acetyldihydrocodeine can be described as the 6-acetyl derivative of dihydrocodeine and is metabolised in the liver by demethylation and deacetylation to produce dihydromorphine."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/69","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=acetyldihydrocodeine","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Acetyldihydrocodeine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T07:29:00.203687","biosimilars":[],"competitors":[{"drugName":"hydrocodone","drugSlug":"hydrocodone","fdaApproval":"1943-03-23","patentExpiry":"Sep 13, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"codeine","drugSlug":"codeine","fdaApproval":"1952-01-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"morphine","drugSlug":"morphine","fdaApproval":"","patentExpiry":"Mar 12, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dextromethorphan","drugSlug":"dextromethorphan","fdaApproval":"1957-12-03","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"acetyldihydrocodeine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrocodone","brandName":"hydrocodone","genericName":"hydrocodone","approvalYear":"1943","relationship":"same-class"},{"drugId":"codeine","brandName":"codeine","genericName":"codeine","approvalYear":"1952","relationship":"same-class"},{"drugId":"morphine","brandName":"morphine","genericName":"morphine","approvalYear":"","relationship":"same-class"},{"drugId":"dextromethorphan","brandName":"dextromethorphan","genericName":"dextromethorphan","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"SGY1T84P34","CHEBI":"CHEBI:135453","UMLSCUI":"C3652939","ChEMBL_ID":"CHEMBL3092041","DRUGBANK_ID":"DB01538","PUBCHEM_CID":"5463874"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"R05DA12","allCodes":["R05DA12"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Acetyldihydrocodeine is a small molecule drug in the acetyldihydrocodeine class, but specific details about its development, commercial status, and approved indications are not available. It is not clear what target it is designed to interact with or what specific conditions it is intended to treat. As a result, there is limited information available about its pharmacokinetic properties, such as half-life and bioavailability. Further research is needed to fully understand the characteristics and potential uses of acetyldihydrocodeine. Its commercial status and safety considerations are also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}