{"id":"acetyldigoxin","rwe":[{"pmid":"37896171","year":"2023","title":"Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"},{"pmid":"32300626","year":"2020","title":"High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants.","finding":"","journal":"Data in brief","studyType":"Clinical Study"},{"pmid":"32035664","year":"2020","title":"Profiling and structural analysis of cardenolides in two species of Digitalis using liquid chromatography coupled with high-resolution mass spectrometry.","finding":"","journal":"Journal of chromatography. A","studyType":"Clinical Study"},{"pmid":"23585247","year":"2013","title":"Prescribing potentially inappropriate medication (PIM) in Germany's elderly as indicated by the PRISCUS list. An analysis based on regional claims data.","finding":"","journal":"Pharmacoepidemiology and drug safety","studyType":"Clinical Study"},{"pmid":"22368709","year":"2012","title":"Prescribing of potentially inappropriate medications for the elderly: an analysis based on the PRISCUS list.","finding":"","journal":"Deutsches Arzteblatt international","studyType":"Clinical Study"}],"tags":[{"label":"acetyldigoxin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01AA02","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"novodigal","offLabel":[],"synonyms":["acetyldigoxin","novodigal","beta-Acetyldigoxin","beta acetyldigoxin"],"timeline":[],"brandName":"Novodigal","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"acetyldigoxin","explanation":"Imagine your heart cells are like muscles that need to contract to pump blood. Novodigal helps these muscles contract more strongly by blocking a pump that normally helps them relax. This makes the heart beat stronger and more efficiently.","oneSentence":"Novodigal works by inhibiting the sodium-potassium ATPase pump in cardiac cells, leading to increased contractility and a stronger heartbeat.","technicalDetail":"Novodigal exerts its effects by competitively inhibiting the sodium-potassium ATPase pump, leading to increased intracellular sodium and calcium levels, which in turn increases the force of cardiac contractions."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/%CE%91-Acetyldigoxin","title":"Α-Acetyldigoxin","extract":"α-Acetyldigoxin is a cardiac glycoside found in plants of the genus Digitalis, including Digitalis lanata. It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/68","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=acetyldigoxin","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=acetyldigoxin","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/%CE%91-Acetyldigoxin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:23:59.796180","biosimilars":[],"competitors":[{"drugName":"acetyldigitoxin","drugSlug":"acetyldigitoxin","fdaApproval":"1975-04-24","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"digitoxin","drugSlug":"digitoxin","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"digoxin","drugSlug":"digoxin","fdaApproval":"1975-10-24","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"deslanoside","drugSlug":"deslanoside","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"acetyldigoxin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetyldigitoxin","brandName":"acetyldigitoxin","genericName":"acetyldigitoxin","approvalYear":"1975","relationship":"same-class"},{"drugId":"digitoxin","brandName":"digitoxin","genericName":"digitoxin","approvalYear":"","relationship":"same-class"},{"drugId":"digoxin","brandName":"digoxin","genericName":"digoxin","approvalYear":"1975","relationship":"same-class"},{"drugId":"deslanoside","brandName":"deslanoside","genericName":"deslanoside","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02364492","phase":"PHASE1","title":"A Phase I Study of a Therapeutic Vaccine Candidate in Patients With Localized Breast Cancer at High-Risk of Relapse","status":"COMPLETED","sponsor":"Institut Pasteur","startDate":"2015-02","conditions":["Breast Neoplasms"],"enrollment":20,"completionDate":"2021-11-11"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000168451","NDDF":"007426","UNII":"P7K44M64CW","CHEBI":"CHEBI:135892","RXNORM":"199","UMLSCUI":"C0001050","ChEMBL_ID":"CHEMBL2074725","DRUGBANK_ID":"DB13691","PUBCHEM_CID":"11765960","MESH_DESCRIPTOR_UI":"D000113"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01AA02","allCodes":["C01AA02","C01AA52"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023 Oct 1","pmid":"37896171","title":"Targeting Lactate Dehydrogenase-B as a Strategy to Fight Cancer: Identification of Potential Inhibitors by In Silico Analysis and In Vitro Screening.","journal":"Pharmaceutics"},{"date":"2020 Jun","pmid":"32300626","title":"High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants.","journal":"Data in brief"},{"date":"2020 May 10","pmid":"32035664","title":"Profiling and structural analysis of cardenolides in two species of Digitalis using liquid chromatography coupled with high-resolution mass spectrometry.","journal":"Journal of chromatography. A"},{"date":"2013 Jul","pmid":"23585247","title":"Prescribing potentially inappropriate medication (PIM) in Germany's elderly as indicated by the PRISCUS list. An analysis based on regional claims data.","journal":"Pharmacoepidemiology and drug safety"},{"date":"2012 Feb","pmid":"22368709","title":"Prescribing of potentially inappropriate medications for the elderly: an analysis based on the PRISCUS list.","journal":"Deutsches Arzteblatt international"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Novodigal, also known as α-Acetyldigoxin, is a small molecule cardiac glycoside. It is being studied as a therapeutic vaccine candidate in a Phase I clinical trial for the treatment of localized breast cancer at high-risk of relapse.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}