{"id":"acetylcysteine-doxofylline","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Tremor"}]},"_chembl":{"chemblId":"CHEMBL1527608","moleculeType":"Small molecule","molecularWeight":"266.26"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetylcysteine reduces mucus viscosity by breaking disulfide bonds in mucoproteins, facilitating clearance of respiratory secretions. Doxofylline is a methylxanthine that provides bronchodilation through phosphodiesterase inhibition and has anti-inflammatory properties, making the combination useful for clearing airways and improving respiratory function in conditions with excessive mucus production.","oneSentence":"Acetylcysteine acts as a mucolytic agent to break down mucus, while doxofylline is a xanthine derivative that acts as a bronchodilator and anti-inflammatory agent.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:24:44.850Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic obstructive pulmonary disease (COPD) with excessive mucus production"},{"name":"Acute and chronic bronchitis"},{"name":"Asthma with mucus obstruction"},{"name":"Cystic fibrosis"}]},"trialDetails":[{"nctId":"NCT03388853","phase":"PHASE4","title":"Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD.","status":"COMPLETED","sponsor":"Neutec Ar-Ge San ve Tic A.Ş","startDate":"2018-02-20","conditions":"COPD","enrollment":68}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Mucofix 1200/400 mg Effervescent Tablet"],"phase":"marketed","status":"active","brandName":"Acetylcysteine/Doxofylline","genericName":"Acetylcysteine/Doxofylline","companyName":"Neutec Ar-Ge San ve Tic A.Ş","companyId":"neutec-ar-ge-san-ve-tic-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acetylcysteine acts as a mucolytic agent to break down mucus, while doxofylline is a xanthine derivative that acts as a bronchodilator and anti-inflammatory agent. Used for Chronic obstructive pulmonary disease (COPD) with excessive mucus production, Acute and chronic bronchitis, Asthma with mucus obstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}