{"id":"acetoxolone","rwe":[{"pmid":"34265050","year":"2021","title":"CONJUGATION WITH SILVER NANOPARTICLES ENHANCES ANTI-ACANTHAMOEBIC ACTIVITY OF KAPPAPHYCUS ALVAREZII.","finding":"","journal":"The Journal of parasitology","studyType":"Clinical Study"}],"tags":[{"label":"acetoxolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Corticosteroid 11-beta-dehydrogenase isozyme 2","category":"target"},{"label":"HSD11B2","category":"gene"},{"label":"HSD11B1","category":"gene"},{"label":"HSD17B2","category":"gene"},{"label":"A02BX09","category":"atc"},{"label":"Active","category":"status"},{"label":"Gastritis","category":"indication"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"glycyrrhetinyl acetate","offLabel":[],"synonyms":["acetoxolone","acetylglycyrrhetic acid","acetylglycyrrhetinic acid","glycyrrhetic acid acetate","glycyrrhetinic acid acetate","glycyrrhetinyl acetate"],"timeline":[],"brandName":"Glycyrrhetinyl Acetate","ecosystem":[{"indication":"Gastritis","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Corticosteroid 11-beta-dehydrogenase isozyme 2","targets":[{"gene":"HSD11B2","source":"DrugCentral","target":"Corticosteroid 11-beta-dehydrogenase isozyme 2","protein":"Corticosteroid 11-beta-dehydrogenase isozyme 2"},{"gene":"HSD11B1","source":"DrugCentral","target":"Corticosteroid 11-beta-dehydrogenase isozyme 1","protein":"Corticosteroid 11-beta-dehydrogenase isozyme 1"},{"gene":"HSD17B2","source":"DrugCentral","target":"Estradiol 17-beta-dehydrogenase 2","protein":"Estradiol 17-beta-dehydrogenase 2"},{"gene":"HSD17B1","source":"DrugCentral","target":"Estradiol 17-beta-dehydrogenase 1","protein":"Estradiol 17-beta-dehydrogenase 1"},{"gene":"CES2","source":"DrugCentral","target":"Cocaine esterase","protein":"Cocaine esterase"},{"gene":"CES1","source":"DrugCentral","target":"Liver carboxylesterase 1","protein":"Liver carboxylesterase 1"}],"modality":"Small Molecule","drugClass":"acetoxolone","explanation":"Think of cortisol like a fire extinguisher. Normally, the body converts cortisol into an inactive form, but acetoxolone blocks this process, allowing more cortisol to be available to put out the fire of inflammation in the stomach.","oneSentence":"Acetoxolone works by inhibiting the enzyme that converts cortisol into its inactive form, allowing more cortisol to be available to reduce inflammation.","technicalDetail":"Acetoxolone specifically inhibits the 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme, which converts cortisol into cortisone, thereby increasing the local concentration of cortisol and reducing inflammation."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Acetoxolone","title":"Acetoxolone","extract":"Acetoxolone is a drug used for peptic ulcer and gastroesophageal reflux disease. It is an acetyl derivative of glycyrrhetinic acid. It is found in Echinopora lamellosa."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/62","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=acetoxolone","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Acetoxolone","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:23:29.918188","biosimilars":[],"competitors":[{"drugName":"sucralfate","drugSlug":"sucralfate","fdaApproval":"1981-10-30","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bismuth subcitrate","drugSlug":"bismuth-subcitrate","fdaApproval":"2006-09-28","relationship":"same-class"}],"genericName":"acetoxolone","indications":{"approved":[{"name":"Gastritis","source":"DrugCentral","snomedId":4556007,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sucralfate","brandName":"sucralfate","genericName":"sucralfate","approvalYear":"1981","relationship":"same-class"},{"drugId":"bismuth-subcitrate","brandName":"bismuth subcitrate","genericName":"bismuth subcitrate","approvalYear":"2006","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004300","UNII":"CWW961Q19K","CHEBI":"CHEBI:81306","RXNORM":"16784","UMLSCUI":"C0050521","ChEMBL_ID":"CHEMBL207413","DRUGBANK_ID":"DB13640","PUBCHEM_CID":"94320","MESH_SUPPLEMENTAL_RECORD_UI":"C013384"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Gastroenterology"],"atcClassification":{"source":"DrugCentral","atcCode":"A02BX09","allCodes":["A02BX09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2021 Jul 1","pmid":"34265050","title":"CONJUGATION WITH SILVER NANOPARTICLES ENHANCES ANTI-ACANTHAMOEBIC ACTIVITY OF KAPPAPHYCUS ALVAREZII.","journal":"The Journal of parasitology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Glycyrrhetinyl Acetate is an acetyl derivative of glycyrrhetinic acid. It is found in Echinopora lamellosa and is related to Acetoxolone, which is used to treat peptic ulcer and gastroesophageal reflux disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}