{"id":"acetazolamide-oral-capsule","safety":{"commonSideEffects":[{"rate":"10-50","effect":"Paresthesia (tingling in extremities)"},{"rate":"10-30","effect":"Altered taste (especially carbonated beverages)"},{"rate":"5-15","effect":"Hypokalemia (low potassium)"},{"rate":"5-10","effect":"Metabolic acidosis"},{"rate":"1-5","effect":"Nephrolithiasis (kidney stones)"},{"rate":"<1","effect":"Stevens-Johnson syndrome (rare)"}]},"_chembl":{"chemblId":"CHEMBL20","moleculeType":"Small molecule","molecularWeight":"222.25"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetazolamide is a carbonic anhydrase inhibitor that decreases the conversion of carbon dioxide and water to bicarbonate and hydrogen ions in the proximal convoluted tubule of the nephron. This inhibition reduces bicarbonate reabsorption, leading to increased urinary bicarbonate and sodium excretion, mild diuresis, and systemic metabolic acidosis. The drug also reduces aqueous humor production in the eye and decreases intracranial pressure.","oneSentence":"Acetazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidney and promoting diuresis and alkalinization of urine.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:17:00.745Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glaucoma and ocular hypertension"},{"name":"Acute mountain sickness"},{"name":"Epilepsy"},{"name":"Idiopathic intracranial hypertension"},{"name":"Periodic paralysis"}]},"trialDetails":[{"nctId":"NCT06043830","phase":"PHASE2","title":"Managing Opioid Related Sleep Apnea With Acetazolamide","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2023-10-18","conditions":"Sleep-Disordered Breathing, Obstructive Sleep Apnea, Central Sleep Apnea","enrollment":39},{"nctId":"NCT07101250","phase":"PHASE4","title":"Preoperative Acetazolamide","status":"RECRUITING","sponsor":"Prisma Health-Upstate","startDate":"2025-10-30","conditions":"Post Operative Pain, Laparoscopic Hysterectomy, Referred Pain","enrollment":100},{"nctId":"NCT06499727","phase":"PHASE4","title":"HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2024-07-15","conditions":"Acute Mountain Sickness","enrollment":303},{"nctId":"NCT05589792","phase":"PHASE1, PHASE2","title":"Acetazolamide on REM OSA","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2023-01-30","conditions":"Obstructive Sleep Apnea","enrollment":11},{"nctId":"NCT02703220","phase":"PHASE4","title":"Sleep Apnea in Elderly","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2015-07-03","conditions":"Sleep Apnea, Elderly Adults","enrollment":100},{"nctId":"NCT07118462","phase":"PHASE4","title":"HighCycle Study: Acetazolamide, High Altitude and Plasma Volume","status":"RECRUITING","sponsor":"Centre d'Expertise sur l'Altitude EXALT","startDate":"2024-07-15","conditions":"High Altitude Effects, High Altitude Hypoxia, Acute Mountain Sickness (AMS)","enrollment":270},{"nctId":"NCT05589753","phase":"PHASE1, PHASE2","title":"Sleep Disordered Breathing With Opioid Use","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2019-05-02","conditions":"Sleep Apnea, Opioid Use, Sleep Disordered Breathing","enrollment":150},{"nctId":"NCT06498505","phase":"PHASE4","title":"HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men","status":"RECRUITING","sponsor":"University of Zurich","startDate":"2024-07-15","conditions":"High Altitude","enrollment":270},{"nctId":"NCT06498531","phase":"PHASE4","title":"HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men","status":"RECRUITING","sponsor":"University of Zurich","startDate":"2024-07-15","conditions":"Sleep-Disordered Breathing","enrollment":270},{"nctId":"NCT04679389","phase":"PHASE2, PHASE3","title":"Acetazolamide Efficacy in Ataxia in PMM2-CDG","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2021-03-17","conditions":"Pmm2-CDG, CDG1A","enrollment":25},{"nctId":"NCT04227093","phase":"PHASE4","title":"Acetazolamide Add-On Therapy to OSA Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Hospital, Antwerp","startDate":"2020-01-22","conditions":"Obstructive Sleep Apnea","enrollment":26},{"nctId":"NCT03540914","phase":"PHASE4","title":"Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude.","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2018-06-01","conditions":"Altitude Hypoxia","enrollment":400},{"nctId":"NCT04913389","phase":"PHASE3","title":"Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2021-06-01","conditions":"Chronic Obstructive Pulmonary Disease, Altitude Sickness, Altitude Hypoxia","enrollment":100},{"nctId":"NCT03537924","phase":"PHASE4","title":"Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2018-06-01","conditions":"Altitude Hypoxia","enrollment":100},{"nctId":"NCT03539367","phase":"PHASE4","title":"Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2018-06-01","conditions":"Altitude Hypoxia","enrollment":100},{"nctId":"NCT04915365","phase":"PHASE3","title":"Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2021-05-01","conditions":"Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness","enrollment":100},{"nctId":"NCT03536507","phase":"PHASE4","title":"Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2018-05-15","conditions":"Altitude Hypoxia","enrollment":185},{"nctId":"NCT03540901","phase":"PHASE4","title":"Effect of Acetazolamide on Lung Water Content by Ultrasound in Patients With Respiratory Disease at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2018-05-22","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":112},{"nctId":"NCT03536429","phase":"PHASE4","title":"Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2018-05-15","conditions":"Altitude Hypoxia","enrollment":99},{"nctId":"NCT03177811","phase":"PHASE4","title":"Effect of Acetazolamide on Postural Control in Patients With Respiratory Disease at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2017-05-24","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":127},{"nctId":"NCT03536520","phase":"PHASE4","title":"Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2018-05-15","conditions":"Altitude Hypoxia","enrollment":59},{"nctId":"NCT03536455","phase":"PHASE4","title":"Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2018-05-15","conditions":"Altitude Hypoxia","enrollment":92},{"nctId":"NCT03561675","phase":"PHASE4","title":"Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2018-05-15","conditions":"Acute Mountain Sickness","enrollment":349},{"nctId":"NCT03177837","phase":"PHASE4","title":"Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2017-05-24","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":176},{"nctId":"NCT03173508","phase":"PHASE4","title":"Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2017-05-24","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":110},{"nctId":"NCT03167034","phase":"PHASE4","title":"Effect of Acetazolamide on Right Ventricular Function During Exercise in Patients With Respiratory Disease at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2017-05-24","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":110},{"nctId":"NCT03165890","phase":"PHASE4","title":"Effect of Acetazolamide on Cognition in Patients With Respiratory Disease at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2017-05-24","conditions":"Chronic Obstructive Pulmonary Disease (COPD)","enrollment":78},{"nctId":"NCT03156231","phase":"PHASE4","title":"Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2017-05-24","conditions":"Chronic Obstructive Pulmonary Disease (COPD)","enrollment":185},{"nctId":"NCT03177850","phase":"PHASE4","title":"Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2017-05-24","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":185},{"nctId":"NCT03720288","phase":"PHASE3","title":"Acetazolamide in Patients With Acute Heart Failure","status":"UNKNOWN","sponsor":"University of Sao Paulo General Hospital","startDate":"2018-10-01","conditions":"Heart Failure, Acute Heart Failure","enrollment":90},{"nctId":"NCT01187108","phase":"PHASE1, PHASE2","title":"Study of Cobalt's Role in Excessive Erythrocytosis Among High Altitude Dwellers in Cerro de Pasco, Peru","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2013-06","conditions":"Erythrocytosis, Mountain Sickness","enrollment":85},{"nctId":"NCT01519544","phase":"NA","title":"Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2012-03","conditions":"High-altitude Sleep Disturbance","enrollment":34},{"nctId":"NCT00780325","phase":"PHASE1","title":"Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition","status":"TERMINATED","sponsor":"University of Pennsylvania","startDate":"2008-10","conditions":"Healthy Volunteers","enrollment":26},{"nctId":"NCT01682551","phase":"PHASE2","title":"Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness","status":"UNKNOWN","sponsor":"China Medical University Hospital","startDate":"2012-09","conditions":"Acute Mountain Sickness (AMS)","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Esomeprazole (Nexium®, AstraZeneca Korea, Co. Ltd., Seoul, Korea) 40 mg, bid, for 7 days","Amoxicillin (Kymoxin®, Yuhan Co. Ltd., Seoul, Korea) 1 g, bid, for 7 days","Clarithromycin (Klaricid®, Abbot Korea Co. Ltd., Seoul, Korea) 500 mg, bid, for 7 days","Acetazolamide (Diamox®, SK Chemicals Co. Ltd., Suwon, Korea) 250mg, bid, for 7 days","Glauseta"],"phase":"marketed","status":"active","brandName":"ACETAZOLAMIDE oral capsule","genericName":"ACETAZOLAMIDE oral capsule","companyName":"University of Zurich","companyId":"university-of-zurich","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acetazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidney and promoting diuresis and alkalinization of urine. Used for Glaucoma and ocular hypertension, Acute mountain sickness, Epilepsy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":16,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}