{"id":"acetazolamide-levamisole","brandName":"Acetazolamide Levamisole","genericName":"Acetazolamide Levamisole","companyId":"the-first-affiliated-hospital-of-zhengzhou-university","companyName":"The First Affiliated Hospital of Zhengzhou University","phase":"phase_3","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Acetazolamide combined with Levamisole is under investigation for the treatment of hepatocellular carcinoma (HCC). A Phase 3 clinical trial is ongoing with 50 participants, aiming to evaluate its efficacy and safety.","enrichmentLevel":3,"visitCount":1,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetazolamide inhibits carbonic anhydrase in the ciliary body, decreasing aqueous humor production and lowering intraocular pressure. Levamisole acts as an immunostimulant, enhancing T-cell function and potentially providing adjunctive therapeutic benefit. The combination targets both the mechanical and immunological aspects of glaucoma or related ocular conditions.","oneSentence":"This combination drug pairs acetazolamide (a carbonic anhydrase inhibitor) with levamisole (an immunomodulator) to reduce intraocular pressure while enhancing immune function.","_ai_confidence":"low"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Paresthesia"},{"rate":null,"effect":"Metabolic acidosis"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Agranulocytosis (levamisole-related)"}]},"trials":[],"indications":{"approved":[{"name":"Glaucoma or elevated intraocular pressure (investigational combination approach)"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}